Association study of gene polymorphisms and depression with abnormal humor in traditional Uighur medicine

Table 1 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G genotype and allele distribution in depression patients and controls

Genotype and allele	ABB group (n= 106)	nABB group (n= 89)	Control group (n= 50)	χ2	P value
Genotype and allele	n (%)	n (%)	n (%)	χ2	P value
5-HT2A A-1438G
Genotype AA	34(32.1)	29(32.6)	18(36.0)	13.31	0.01
AG	67(63.2)	45(50.6)	21(42.0)
GG	5(4.7)	15(16.9)	11(22.0)
P value	0.002^a	0.59
Alleles A	135(63.7)	103(57.9)	57(57.0)	1.9	0.39
G	77(36.3)	75(42.1)	43(43.0)	1.9	0.39
P value	0.26	0.89
5-HT2A T102C
Genotype TT	34(32.1)	30(33.7)	19(38.0)	15.69	0
TC	68(64.2)	45(50.6)	20(40.0)
CC	4(3.8)	14(15.7)	11(22.0)
P value	0.000^b	0.44
Alleles T	136(64.2)	105(59.0)	58(58.0)	1.57	0.46
C	76(35.8)	73(41.0)	42(42.0)	1.57	0.46
P value	0.3	0.87
BDNF Val66Met
Genotype Val/Val	51(48.1)	35(39.3)	12(24.0)	17.79	0
Met/Val	51(48.1)	42(47.2)	26(52.0)
Met/Met	4(3.8)	12(13.5)	12(24.0)
P value	0.040^c	0.11
Alleles Val	153(72.2)	112(63.0)	50(50.0)	14.77	0
Met	59(27.8)	66(37.0)	50(50.0)	14.77	0
P value	0.000^d	0.04
5-HT1A C-1019G
Genotype CC	46(43.4)	40(45.0)	15(30.0)	14.63	0.01
CG	55(51.9)	35(39.3)	23(46.0)
GG	5(4.7)	14(15.7)	12(24.0)
P value	0.001^e	0.19
Alleles C	147(69.3)	115(64.6)	53(53.0)	7.91	0.02
G	65(30.7)	63(35.4)	47(47.0)	7.91	0.02
P value	0.005^f	0.06

^aOdds ratio (and 95% confidence interval) for GG vs (A/G + A/A) is 0.176(0.057 ~ 0.538), χ2= 11.O25, df= 1, P= 0.001.
^bOdds ratio (and 95% confidence interval) for CC vs (T/C + T/T) is 0.139(0.042 ~ 0.463), χ2= 12.987, df= 1, P= 0.000.
^cOdds ratio (and 95% confidence interval) for Val/Val vs (Val/Met + Met/Met) is 2.936(1.383 ~ 6.232), χ2= 8.205, df= 1, P= 0.004, and Met/Met vs Val/Met + Val/Val is 0.124(0.038 ~ 0.409), χ2= 15.100, df= 1, P= 0.000.
^dOdds ratio (and 95% confidence interval) for Met allele vs Val allele is 2.936(1.383 ~ 6.232), χ2= 14.692, df= 1, P= 0.000.
^eOdds ratio (and 95% confidence interval) for GG vs (G/C + C/C) is 0.157(0.052 ~ 0.475), χ2= 13.010, df= 1, P= 0.000.
^fOdds ratio (and 95% confidence interval) for C allele vs G allele is 2.006(1.229 ~ 3.271), χ2= 7.884, df= 1, P= 0.005.

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