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Table 1 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G genotype and allele distribution in depression patients and controls

From: Association study of gene polymorphisms and depression with abnormal humor in traditional Uighur medicine

Genotype and allele ABB group (n= 106) nABB group (n= 89) Control group (n= 50) χ2 P value
n (%) n (%) n (%)
5-HT2A A-1438G      
Genotype AA 34(32.1) 29(32.6) 18(36.0) 13.31 0.01
AG 67(63.2) 45(50.6) 21(42.0)
GG 5(4.7) 15(16.9) 11(22.0)
P value 0.002a 0.59    
Alleles A 135(63.7) 103(57.9) 57(57.0) 1.9 0.39
G 77(36.3) 75(42.1) 43(43.0)
P value 0.26 0.89    
5-HT2A T102C      
Genotype TT 34(32.1) 30(33.7) 19(38.0) 15.69 0
TC 68(64.2) 45(50.6) 20(40.0)
CC 4(3.8) 14(15.7) 11(22.0)
P value 0.000b 0.44    
Alleles T 136(64.2) 105(59.0) 58(58.0) 1.57 0.46
C 76(35.8) 73(41.0) 42(42.0)
P value 0.3 0.87    
BDNF Val66Met      
Genotype Val/Val 51(48.1) 35(39.3) 12(24.0) 17.79 0
Met/Val 51(48.1) 42(47.2) 26(52.0)
Met/Met 4(3.8) 12(13.5) 12(24.0)
P value 0.040c 0.11    
Alleles Val 153(72.2) 112(63.0) 50(50.0) 14.77 0
Met 59(27.8) 66(37.0) 50(50.0)
P value 0.000d 0.04    
5-HT1A C-1019G      
Genotype CC 46(43.4) 40(45.0) 15(30.0) 14.63 0.01
CG 55(51.9) 35(39.3) 23(46.0)
GG 5(4.7) 14(15.7) 12(24.0)
P value 0.001e 0.19    
Alleles C 147(69.3) 115(64.6) 53(53.0) 7.91 0.02
G 65(30.7) 63(35.4) 47(47.0)
P value 0.005f 0.06    
  1. aOdds ratio (and 95% confidence interval) for GG vs (A/G + A/A) is 0.176(0.057 ~ 0.538), χ2= 11.O25, df= 1, P= 0.001.
  2. bOdds ratio (and 95% confidence interval) for CC vs (T/C + T/T) is 0.139(0.042 ~ 0.463), χ2= 12.987, df= 1, P= 0.000.
  3. cOdds ratio (and 95% confidence interval) for Val/Val vs (Val/Met + Met/Met) is 2.936(1.383 ~ 6.232), χ2= 8.205, df= 1, P= 0.004, and Met/Met vs Val/Met + Val/Val is 0.124(0.038 ~ 0.409), χ2= 15.100, df= 1, P= 0.000.
  4. dOdds ratio (and 95% confidence interval) for Met allele vs Val allele is 2.936(1.383 ~ 6.232), χ2= 14.692, df= 1, P= 0.000.
  5. eOdds ratio (and 95% confidence interval) for GG vs (G/C + C/C) is 0.157(0.052 ~ 0.475), χ2= 13.010, df= 1, P= 0.000.
  6. fOdds ratio (and 95% confidence interval) for C allele vs G allele is 2.006(1.229 ~ 3.271), χ2= 7.884, df= 1, P= 0.005.