Figure 4

Corilagin induces G2/M cell cycle arrest and inhibits cell cycle-related proteins. (A) Hey and SKOv3ip cells were treated with Corilagin (40 μM). Cell cycle analyses were performed using flow cytometry after two days of treatment. Cells without treatment were used as the control. The experiments were repeated twice (see Table 1), with the figure depicting a representative experiment. (B) Hey and SKOv3ip cells were treated with Corilagin for two days at different concentrations (lower, 20 μM, and higher, 40 μM). Cells without treatment were used as the control. Cyclin B1, p-Weel, p-cdc2 and Myt1 levels were analyzed by Western blotting.