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Table 4 Cytotoxic activity (IC 50 μg/ml) of A. scabra rhizome extracts

From: Cytotoxic effect of Alpinia scabra (Blume) Náves extracts on human breast and ovarian cancer cells

Extracts Treatment duration (hour) IC50 a(μg/ml) (SIb)
MCF7 SKOV-3 MRC-5
Methanol 24 >100 >100 >100
48 >100 >100 >100
72 >100 >100 >100
Hexane 24 79.67 ± 10.60 40.00 ± 2.00 73.69 ± 2.23
48 60.00 ± 5.66 25.67 ± 0.58 41.31 ± 2.26
72 57.33 ± 1.15 24.00 ± 3.46 53.49 ± 2.71
Chloroform 24 70.67 ± 23.12 21.67 ± 4.73 78.08 ± 7.76
48 39.00 ± 1.41 19.33 ± 0.58 (2.3) 43.56 ± 0.54
72 37.67 ± 0.58 17.33 ± 0.58 (2.6) 44.65 ± 2.57
Water 24 >100 >100 >100
48 >100 >100 >100
72 >100 >100 >100
Doxorubicinc 24 2.50 ± 0.10 2.50 ± 0.10 >100
48 2.37 ± 0.23 (32.4) 1.77 ± 0.15 (43.4) 76.87 ± 12.64
72 0.39 ± 0.02 (4.3) 1.47 ± 0.15 (1.1) 1.68 ± 0.42
  1. aData are presented as mean ± SD from three independent experiments triplicate for each. Values in bold characters are considered to have cytotoxic activity (IC5020 μg/ml or less); bSelectivity Index (SI); cPositive control.