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Table 3 Cytotoxic activity (IC 50 ) of A. scabra leaf extracts

From: Cytotoxic effect of Alpinia scabra (Blume) Náves extracts on human breast and ovarian cancer cells

Extracts Treatment duration (hour) IC50 a(μg/ml) (SIb)
MCF7 SKOV-3 MRC-5
Methanol 24 90.67 ± 6.11 47.00 ± 11.53 >100
48 56.27 ± 9.18 37.67 ± 2.52 57.58 ± 1.25
72 53.33 ± 6.43 34.33 ± 0.58 65.35 ± 1.68
Hexane 24 19.30 ± 5.70 (1.6) 18.00 ± 2.65 (1.7) 31.38 ± 2.31
48 15.30 ± 4.04 (1.0) 6.00 ± 1.00 (2.4) 14.63 ± 2.08
72 16.33 ± 0.58 (1.0) 4.93 ± 0.12 (3.2) 15.90 ± 0.94
Chloroform 24 18.80 ± 1.06 (2.4) 20.00 ± 1.00 (2.3) 45.88 ± 3.81
48 23.67 ± 7.64 14.33 ± 1.53 (2.3) 32.26 ± 2.11
72 25.00 ± 0.00 14.67 ± 0.58 (2.2) 32.90 ± 0.76
Water 24 >100 >100 >100
48 >100 >100 >100
72 >100 >100 >100
Doxorubicinc 24 2.50 ± 0.10 2.50 ± 0.10 >100
48 2.37 ± 0.23 (32.4) 1.77 ± 0.15 (43.4) 76.87 ± 12.64
72 0.39 ± 0.02 (4.3) 1.47 ± 0.15 (1.1) 1.68 ± 0.42
  1. aData are presented as mean ± SD from three independent experiments triplicate for each. Values in bold characters are considered to have cytotoxic activity (IC5020 μg/ml or less); bSelectivityIndex (SI); cPositive control.