Table 3 Cytotoxic activity (IC 50 ) of A. scabra leaf extracts
From: Cytotoxic effect of Alpinia scabra (Blume) Náves extracts on human breast and ovarian cancer cells
Extracts | Treatment duration (hour) | IC50 a(μg/ml) (SIb) | ||
|---|---|---|---|---|
MCF7 | SKOV-3 | MRC-5 | ||
Methanol | 24 | 90.67 ± 6.11 | 47.00 ± 11.53 | >100 |
48 | 56.27 ± 9.18 | 37.67 ± 2.52 | 57.58 ± 1.25 | |
72 | 53.33 ± 6.43 | 34.33 ± 0.58 | 65.35 ± 1.68 | |
Hexane | 24 | 19.30 ± 5.70 (1.6) | 18.00 ± 2.65 (1.7) | 31.38 ± 2.31 |
48 | 15.30 ± 4.04 (1.0) | 6.00 ± 1.00 (2.4) | 14.63 ± 2.08 | |
72 | 16.33 ± 0.58 (1.0) | 4.93 ± 0.12 (3.2) | 15.90 ± 0.94 | |
Chloroform | 24 | 18.80 ± 1.06 (2.4) | 20.00 ± 1.00 (2.3) | 45.88 ± 3.81 |
48 | 23.67 ± 7.64 | 14.33 ± 1.53 (2.3) | 32.26 ± 2.11 | |
72 | 25.00 ± 0.00 | 14.67 ± 0.58 (2.2) | 32.90 ± 0.76 | |
Water | 24 | >100 | >100 | >100 |
48 | >100 | >100 | >100 | |
72 | >100 | >100 | >100 | |
Doxorubicinc | 24 | 2.50 ± 0.10 | 2.50 ± 0.10 | >100 |
48 | 2.37 ± 0.23 (32.4) | 1.77 ± 0.15 (43.4) | 76.87 ± 12.64 | |
72 | 0.39 ± 0.02 (4.3) | 1.47 ± 0.15 (1.1) | 1.68 ± 0.42 | |