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Table 4 Mean number (± SD) of aberrant crypt foci (ACF) and aberrant crypt (AC) observed in the distal colon of rats treated with the C. langsdorffii extract and DMH

From: Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Treatments (mg/kg)

Number of ACF

Number of ACF

Number of AC

AC/ACF

 

1

2

3

4

   

DMH

9.2 ± 1.2

3.2 ± 1.3

1.2 ± 0.9

0.5 ± 0.8

14.0 ± 1.4

20.8 ± 1.9

1.5 ± 0.1

DMSO + DMH

6.7 ± 2.6

3.5 ± 1.9

2.2 ± 1.5

0.3 ± 0.8

12.8 ± 3.5

21.0 ± 5.9

1.6 ± 0.2

20 + DMH

7.2 ± 1.6

4.8 ± 1.7

2.2 ± 0.8

0.2 ± 0.4

14.3 ± 2.7b

23.7 ± 5.3b

1.6 ± 0.2

40 + DMH

6.2 ± 2.3

4.0 ± 0.7

0

0.4 ± 0.5

10.6 ± 1.9a

15.8 ± 2.9a

1.5 ± 0.2

80 + DMH

4.7 ± 0.8

2.7 ± 1.2

0.7 ± 0.8

0.2 ± 0.4

8.0 ± 1.9a

12.0 ± 4.0a

1.5 ± 0.2

  1. DMH, 1,2-dimethylhydrazine (160 mg/kg); DMSO, dimethylsulfoxide (0.6 g/kg). The numbers 20, 40, and 80 correspond to the extract dose in g/kg.
  2. *Values are the mean ± standard deviation.
  3. aSignificantly different from the DMH group (P < 0.05).
  4. bSignificantly different from the 40 + DMH and 80 + DMH groups (P < 0.05).