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Table 4 Mean number (± SD) of aberrant crypt foci (ACF) and aberrant crypt (AC) observed in the distal colon of rats treated with the C. langsdorffii extract and DMH

From: Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Treatments (mg/kg) Number of ACF Number of ACF Number of AC AC/ACF
  1 2 3 4    
DMH 9.2 ± 1.2 3.2 ± 1.3 1.2 ± 0.9 0.5 ± 0.8 14.0 ± 1.4 20.8 ± 1.9 1.5 ± 0.1
DMSO + DMH 6.7 ± 2.6 3.5 ± 1.9 2.2 ± 1.5 0.3 ± 0.8 12.8 ± 3.5 21.0 ± 5.9 1.6 ± 0.2
20 + DMH 7.2 ± 1.6 4.8 ± 1.7 2.2 ± 0.8 0.2 ± 0.4 14.3 ± 2.7b 23.7 ± 5.3b 1.6 ± 0.2
40 + DMH 6.2 ± 2.3 4.0 ± 0.7 0 0.4 ± 0.5 10.6 ± 1.9a 15.8 ± 2.9a 1.5 ± 0.2
80 + DMH 4.7 ± 0.8 2.7 ± 1.2 0.7 ± 0.8 0.2 ± 0.4 8.0 ± 1.9a 12.0 ± 4.0a 1.5 ± 0.2
  1. DMH, 1,2-dimethylhydrazine (160 mg/kg); DMSO, dimethylsulfoxide (0.6 g/kg). The numbers 20, 40, and 80 correspond to the extract dose in g/kg.
  2. *Values are the mean ± standard deviation.
  3. aSignificantly different from the DMH group (P < 0.05).
  4. bSignificantly different from the 40 + DMH and 80 + DMH groups (P < 0.05).