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Table 3 DNA migration in the comet assay observed in Wistar rat colon treated with different doses of the C. langsdorffii extract and/or DMH and their respective controls

From: Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Treatments (mg/kg) Comet class* *Score Reduction
  0 1 2 3   (%)
Control 66.2 ± 4.3 23.2 ± 5.7 7.3 ± 2.3 3.3 ± 1.8 47.8 ± 6.4 -
DMSO 65.3 ± 3.9 21.2 ± 4.4 8.3 ± 2.4 3.7 ± 2.2 48.8 ± 4.8 -
80 79.7 ± 5.1 14.7 ± 6.3 5.0 ± 2.6 0.7 ± 0.8 26.7 ± 6.0 -
DMH 13.2 ± 2.1 26.2 ± 5.3 33.5 ± 5.2 27.3 ± 3.7 175.2 ± 9.6a -
DMSO + DMH 11.5 ± 1.6 23.8 ± 9.5 32.8 ± 8.3 28.7 ± 4.3 175.5 ± 11.7a -
20 + DMH 10.8 ± 4.5 40.2 ± 3.6 25.0 ± 6.4 22.3 ± 4.3 157.2 ± 12.2a,b 14.3
40 + DMH 19.3 ± 6.3 34.0 ± 4.3 29.7 ± 3.6 16.8 ± 5.9 143.8 ± 15.1a,b 24.7
80 + DMH 23.3 ± 6.9 40.8 ± 7.1 20.8 ± 3.5 15.0 ± 5.9 125.8 ± 12.7a,b,c 38.8
  1. A total of 600 cells were examined per treatment; DMH, 1,2-dimethylhydrazine (40 mg/kg). The numbers 20, 40, and 80 correspond to the extract dose in mg/kg.
  2. *Values are the mean ± standard deviation.
  3. aSignificantly different from the control (P < 0.05).
  4. bSignificantly different from the DMH group (P <0.05).
  5. cSignificantly different from the 20 + DMH group (P < 0.05).