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Table 2 Final body weight, body weight gain, and water consumption of rats treated with different doses of the C. langsdorffii extract and/or DMH and their respective controls, for the aberrant crypt foci (ACF) assay

From: Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Treatments (mg/kg) Final body weight (g)* Body weight gain (g)* Water consumption*a
EDTA 326.8 ± 12.5 215.6 ± 11.9 37.5 ± 6.8
DMSO 335.6 ± 11.2 214.5 ± 11.7 37.5 ± 4.4
80 325.5 ± 12.8 219.0 ± 11.5 37.5 ± 6.8
DMH 321.8 ± 10.1 222.5 ± 10.7 37.9 ± 5.8
DMSO + DMH 334.3 ± 11.3 223.5 ± 11.0 45.5 ± 7.2
20 + DMH 334.5 ± 10.9 224.3 ± 10.8 37.2 ± 6.5
40 + DMH 341.8 ± 11.5 221.8 ± 11.1 44.6 ± 12.3
80 + DMH 340.5 ± 12.1 225.5 ± 11.8 55.0 ± 18.7
  1. EDTA, vehicle control; DMH, 1,2-dimethylhydrazine (160 mg/kg); DMSO, dimethylsulfoxide (0.6 g/kg). The numbers 20, 40, and 80 correspond to the extract dose in mg/kg.
  2. *Values are the mean ± standard deviation.
  3. aWater consumption calculated in mL per animal per day.