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Table 2 Final body weight, body weight gain, and water consumption of rats treated with different doses of the C. langsdorffii extract and/or DMH and their respective controls, for the aberrant crypt foci (ACF) assay

From: Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon

Treatments (mg/kg)

Final body weight (g)*

Body weight gain (g)*

Water consumption*a

EDTA

326.8 ± 12.5

215.6 ± 11.9

37.5 ± 6.8

DMSO

335.6 ± 11.2

214.5 ± 11.7

37.5 ± 4.4

80

325.5 ± 12.8

219.0 ± 11.5

37.5 ± 6.8

DMH

321.8 ± 10.1

222.5 ± 10.7

37.9 ± 5.8

DMSO + DMH

334.3 ± 11.3

223.5 ± 11.0

45.5 ± 7.2

20 + DMH

334.5 ± 10.9

224.3 ± 10.8

37.2 ± 6.5

40 + DMH

341.8 ± 11.5

221.8 ± 11.1

44.6 ± 12.3

80 + DMH

340.5 ± 12.1

225.5 ± 11.8

55.0 ± 18.7

  1. EDTA, vehicle control; DMH, 1,2-dimethylhydrazine (160 mg/kg); DMSO, dimethylsulfoxide (0.6 g/kg). The numbers 20, 40, and 80 correspond to the extract dose in mg/kg.
  2. *Values are the mean ± standard deviation.
  3. aWater consumption calculated in mL per animal per day.