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Table 2 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the striatum of mice brain

From: Antidepressant-like activity of turmerone in behavioral despair tests in mice

Group

NE

MHPG

DA

DOPAC

5-HT

5-HIAA

5-HIAA/5-HT

Normal

356.0 ± 9.6

238.0 ± 12.4

526.0 ± 9.2

157.7 ± 14.8

353.3 ± 18.7

214.1 ± 8.5

0.62 ± 0.05

Control + FST

262.3 ± 19.4

261.3 ± 9.6

342.9 ± 8.2###

150.1 ± 7.2

253.9 ± 9.8#

283.0 ± 2.9

1.07 ± 0.08###

Fluoxetine 10 mg/kg + FST

310.4 ± 4.7

236.2 ± 4.8

413.8 ± 5.0

144.6 ± 2.2

599.6 ± 8.8***

204.7 ± 3.4

0.34 ± 0.01***

Turmerone 2.5 mg/kg + FST

379.1 ± 43.2*

256.4 ± 3.3

933.5 ± 23.1***

129.7 ± 5.6

852.8 ± 15.3***

206.4 ± 5.6*

0.26 ± 0.01***

Turmerone 5.0 mg/kg + FST

327.8 ± 12.7

253.3 ± 6.8

776.9 ± 23.8***

137.5 ± 5.3

731.8 ± 17.6***

204.2 ± 20.9*

0.28 ± 0.03***

  1. Values were the means ± SEM (n = 10). # p < 0.05, ### p < 0.001 as compared with the normal group. * p < 0.05, ** p < 0.01,*** p <0.001 as compared with the control + FST group. (One-way ANOVA following by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.