Antidepressant-like activity of turmerone in behavioral despair tests in mice

Table 1 Effect of turmerone on the concentrations (ng/g tissue) of monoamines and their metabolites in the cortex of mice brain

Group	NE	MHPG	DA	DOPAC	5-HT	5-HIAA	5-HIAA/5-HT
Normal	402.4 ± 19.8	243.1 ± 6.2	83.5 ± 5.6	72.2 ± 2.7	432.1 ± 22.3	127.2 ± 7.7	0.30 ± 0.03
Control + FST	200.5 ± 23.5^###	228.9 ± 15.6	48.1 ± 2.0^##	44.6 ± 1.5	326.9 ± 15.5^#	255.2 ± 41.8^##	0.75 ± 0.14^##
Fluoxetine 10 mg/kg + FST	283.4 ± 3.3	180.4 ± 7.6	58.7 ± 1.7	47.4 ± 1.8	600.2 ± 6.1^***	214.3 ± 3.3	0.36 ± 0.01^**
Turmerone 2.5 mg/kg + FST	254.9 ± 9.1	172.4 ± 5.2	69.7 ± 6.3	46.9 ± 1.4	734.8 ± 18.6^***	237.0 ± 22.0	0.33 ± 0.03^**
Turmerone 5.0 mg/kg + FST	384.2 ± 31.3^***	179.3 ± 5.5^*	48.6 ± 8.6	42.5 ± 2.5	629.9 ± 25.5^***	250.2 ± 14.0	0.42 ± 0.02

Values were the means ± SEM (n = 10). ^# p < 0.05, ^{# #} p < 0.01, ^{# # #} p < 0.001 as compared with the normal group. ^** p < 0.01, ^*** p < 0.001 as compared with the control + FST group. (One-way ANOVA followed by Scheffe’s test). NE: norepinephrine, MHPG: 3 methoxy-4-hydroxyphenylglycol, DA: dopamine, DOPAC: 3,4-dihydroxyphenylacetic acid, 5-HT: serotonin, 5-HIAA: 5-hydroxyindoleacetic acid.

ISSN: 2662-7671