Antibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgaris

Table 1 Antibacterial, antioxidant and cytotoxic effects of ethanol extract of Syzygium jambos , fractions and compounds

Test samples	Antibacterial	Antioxidant		Cytotoxicity
	MIC μg/ml	IC₅₀μg/ml/(μM)	Mg Vit C equivalents/g dry weight	B16-F10 mouse melanocytes	U937 human macrophage
	MIC μg/ml	IC₅₀μg/ml/(μM)	Mg Vit C equivalents/g dry weight	EC₅₀μg/ml/(μM)
Syzygium jambos	31.3	0.9	450.0	60.0	440.0
MF 1,3,5,7-12	^aNa	^b-	-	-	-
MF 2	500.0	-	-	-	-
MF 4	62.5	-	-	-	-
MF 6	250.0	-	-	-	-
Squalene	Na	>100	-	>100	>100
Anacardic acid analogue	7.9	>100	-	^cNt	57.8
Ursolic acid	Na	>100	-	Nt	38.0/(83.2)
Myricetin	Na	0.9/(3)	2105.0	11.1/(35.1)	19.3/(60)
Myricitrin	Na	1.8/(4)	1081.0	259.0/(557.8)	318.0/(684.7)
Gallic acid	Na	0.8/(4.8)	2444.9	2.2/(13.1)	28.4/(169)
^dPC	3.1/(7)	1.9/(11.3)	-	4.5 × 10^-3/(3.5 × 10 ⁶ )	4.5 × 10^-3/(3.5 × 10 ⁶ )

^anot active at the highest concentration tested (500 μg/ml).
^bnot applicable: for MF as not tested for antioxidant activity and cytotoxicity, mg equivalent could not be detected for non-antioxidant compounds.
^cnot tested due to low yield of the compound.
^dpositive drug control where tetracycline for antibacterial, vitamin C for antioxidant, actinomycin D for cytotoxicity.

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