Skip to main content

Advertisement

Table 1 Experimental groups of animals and substances administered

From: Attenuating effect of standardized fruit extract of punica granatum L in rat model of tibial and sural nerve transection induced neuropathic pain

Groups n Substance Description
I 6 Normal control Only fodder and water.
II 6 Sham control Tibial and Sural nerve exposed without any transaction.
III 6 TST TST were performed.
IV 6 Vehicle in TST CMC 0.5% w/v, p. o. was administered for 24 days daily.
V 6 PFE per se PFE (300 mg/kg p. o. ones daily) was administered to the normal rats for 24 consecutive days.
VI&VII 6 PFE + TST PFE (100 and 300 mg/kg p. o. respectively) were administered to the TST rats for 24 consecutive days
VIII 6 BADGE (PPAR-γ antagonist) + TST BADGE was administered (120 mg/kg IP) to the TST rats for 24 consecutive days.
IX & X 6 BADGE + PFE + TST BADGE was administered (120 mg/kg IP) before PFE (100 and 300 mg/kg p. o. respectively) administration to the TST rats for 24 consecutive days.
XI 6 L-NAME + TST L-NAME was administered (5 mg/kg IP) to the TST rats for 24 consecutive days.
XII 6 L-arginine + TST L-arginine was administered (100 mg/kg IP) to the TST rats for 24 consecutive days.
XIII & XIV 6 L-NAME + PFE + TST L-NAME was administered (5 mg/kg IP) before PFE (100 and 300 mg/kg p. o. respectively) administration to the TST rats for 24 consecutive days.
XV & XVI 6 L-arginine + PFE + TST L-arginine was administered (100 mg/kg IP) before PFE (100 and 300 mg/kg p. o. respectively) administration to the TST rats for 24 consecutive days.
XVII 6 Gabapentin per se Gabapentin (100 mg/kg) p. o. administration to the normal rats for 24 consecutive days.
XVIII 6 Gabapentin + TST Gabapentin (100 mg/kg) p. o. administration to the TST rats for 24 consecutive days.
  1. TST- Tibial and Sural Nerve Transection; CMC – carboxymethylcellulose; PFE - Punica granatum L Fruit Extract; BADGE- Biphenol-A-diglicydyl ether; p. o.- per os; IP- Intraperitoneal.