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Table 3 Effect of umbelliferone β-D-galactopyranoside on biochemical parameters in STZ-induced diabetic rats

From: Umbelliferone β-D-galactopyranoside from Aegle marmelos (L.) corr. an ethnomedicinal plant with antidiabetic, antihyperlipidemic and antioxidative activity

S. No.

Biochemical parameter

Normal control

Normal control + UFG (40 mg/kg)

STZ-diabetic controla

STZ diabetes + UFG (10 mg/kg)b

STZ diabetes + UFG (20 mg/kg)b

STZ diabetes + UFG (40 mg/kg)b

STZ diabetes + glibenclamideb

1

Fasting plasma glucose (mg/dL)

91.2 ± 1.114

87.6 ± 1.031

394.2 ± 3.992***

193.2 ± 1.393**

166.2 ± 2.332***

123.4 ± 2.379***

136.4 ± 1.99***

2

Fasting Plasma Insulin (μU/mL)

11.2 ± 0.374

12.2 ± 0.374

2.8 ± 0.383***

4.4 ± 0.509*

6.8 ± 0.374**

9.4 ± 0.519***

8.6 ± 0.609***

3

Glycated Heamoglobin (A1c) (%)

1.4 ± 0.141

1.36 ± 0.157

4.82 ± 2.49***

3.8 ± 0.184*

3.42 ± 0.182**

1.86 ± 0.161***

2.04 ± 0.212***

4

Hexokinase (μg/mg of tissue)

150.4 ± 3.356

152 ± 3.146

100.8 ± 1.655***

112.6 ± 1.778**

127.6 ± 1.327**

141.2 ± 1.934***

139 ± 1.225***

5

Glucose-6-Phosphatase (unit/mg of tissue)

10 ± 0.948

10 ± 1.095

15.4 ± 0.509***

14.4 ± 0.612ns

12.8 ± 0.374*

10.8 ± 0.583***

11.6 ± 0.244***

6

Fructose-1-6-biphosphatase (unit/mg of tissue)

30.8 ± 0.861

29.80 ± 0.489

54.6 ± 2.619***

47.4 ± 1.166*

38.2 ± 1.281**

32.2 ± 0.861***

34.8 ± 0.583***

7

Total Cholesterol (mg/dL)

66.6 ± 1.503

64.8 ± 1.655

155.8 ± 3.865***

97.2 ± 1.158**

82.2 ± 2.417**

61.2 ± 2.131***

66.2 ± 1.463***

8

Triglycerides (mg/dL)

82.4 ± 3.231

80 ± 1.378

154.6 ± 1.161***

131.8 ± 1.163*

123.2 ± 1.660**

96.2 ± 1.392***

108.4 ± 1.071***

9

Total HDL Cholesterol (mg/dL)

58.6 ± 1.913

59.8 ± 4.266

30.8 ± 1.319***

42.8 ± 1.356*

50.4 ± 0.927**

59.2 ± 1.068***

55.8 ± 1.167***

10

Total LDL Cholesterol (mg/dL)

37.9 ± 1.206

33.4 ± 1.188

197 ± 6.647***

118.5 ± 1.201**

65.5 ± 1.391***

44.4 ± 1.668***

61.8 ± 1.559***

11

Total VLDL Cholesterol (mg/dL)

16.48 ± 0.326

16 ± 0.276

30.92 ± 0.647***

26.36 ± 0.232*

24.72 ± 0. 331**

19.24 ± 0.279***

21.68 ± 0.215***

12

Weight Variation (g) ±

196 ± 0.775

197.6 ± 1.288

165.2 ± 3.382***

190.4 ± 4.686***

195 ± 3.761***

203.2 ± 4.428***

183.4 ± 5.269***

  1. All values represent mean ± SEM * P < 0.05; ** P < 0.01; *** P < 0.001, ns < non significant; ANOVA, followed by Dunnett’s multiple comparison test.
  2. aCompared to vehicle control.
  3. bCompared to diabetic control.