Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression

Table 2 Activity of the HPA on handled rats and non treated TLE rats

Groups	ACTH (pg/ml)	Corticosterone (pg/ml)	Adrenal gland weight (Percentage of body weight) (%)
Handled	0.512 ± 0.114	4126.76 ± 298	0.0076 ± 0.0008
Non treated TLE rats	0.761 ± 0.113*	8267.05 ± 510***	0.0099 ± 0.0014*

TLE was induced by injecting rats intraperitoneally (i.p.) with pilocarpine (350 mg/kg). Thirty minutes prior to the pilocarpine injection, the animals were treated with atropine (1 mg/ kg, i.p.) to reduce peripheral pilocarpine effects. Results are the mean ± SEM of n = 5 rats per group.
* p < 0.05, significantly different from handling group (Student’s t-test).
*** p < 0.001, significantly different from handling group (Student’s t-test).

ISSN: 2662-7671