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Table 1 In vitro antimycobacterial activity of Ursolic acid (UA) and Oleanolic acid (OA) tested by MABA assay

From: Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment

M. tuberculosis strain MIC (μg mL-1)
(ATCC) UA OA UA/OA
H37Rv (27294) 25 50 12.5
INH-R (35822) 25 25 25
RIF-R (35838) 25 25 25
EMB-R (35837) 25 25 25
STR-R (35820) 12.5 50 25
DR clinical isolates
MMDO 25 50 ND
MTY147 25 50 ND
Non-tuberculous mycobacterium
M. chelonae 100 100 100
M. avium 100 100 100
M. smegmatis >200 100 100
M. fortuitum 100 100 100
M. simiae >200 100 100
  1. H37Rv: sensitive strain to INH, RIF, EMB, STR, and pyrazinamide; RIF-R: rifampicin-resistant to H37Rv; STR-R: streptomycin-resistant to H37RV; INH-R: isoniazid-resistant to H37Rv and EMB-R: ethambutol-resistant to H37Rv; MMDO: strain resistant to isoniazid and ethambutol; MTY 147: strain resistant to isoniazid, rifampicin, ethambutol and ethionamide. MIC: minimum inhibitory concentration. Data are means of three determinations. UA: ursolic acid; OA: oleanolic acid; UA/OA: mixture of ursolic and oleanolic acids.