Table 2 Cytotoxicity of the studied extracts towards sensitive and drug-resistant cancer cell lines and normal cells as determined by the resazurin assay
Cell lines | Samples, IC50values (μg/mL) and degree of resistancea(in brakets) | ||||||
|---|---|---|---|---|---|---|---|
| Â | Crinum zeylanicum | Dioscorea bulbifera | Elaoephorbia drupifera | Entada abyssinica | Eremomastax speciosa | Polistigma thonningii | Doxorubucin |
CCRF-CEM | 17.22 ± 2.19 | 19.77 ± 2.22 | 11.86 ± 1.19 | 15.81 ± 1.47 | 23.65 ± 2.51 | 26.44 ± 1.18 | 0.11 ± 0.01 |
CEM/ADR5000 | 23.67 ± 1.97 (1.38) | - (>2.02) | 13.72 ± 0.97(1.12) | - (>2.53) | 38.71 ± 4.12 (1.64) | - (>1.51) | 195.12 ± 14.30 (1772) |
MDA-MB231 | 18.01 ± 1.61 | 33.17 ± 2.91 | 8.40 ± 0.55 | 29.14 ± 1.83 | 35.13 ± 2.49 | 34.19 ± 2.24 | 1.10 ± 0.01 |
MDA-MB231/BCRP | 11.18 ± 1.11 (0.62) | - (>1.21) | 30.96 ± 2.74(3.69) | - (>1.37) | - (>1.14) | - (>1.17) | 7.83 ± 0.01 (7.11) |
HCT116 (p53 +/+ ) | 4.32 ± 0.52 | 36.14 ± 2.37 | 25.36 ± 2.13 | 9.55 ± 1.11 | - | - | 1.43 ± 0.02 |
HCT116 (p53 -/- ) | 7.45 ± 0.64 (1.73) | - (<0.69) | 28.61 ± 3.08(1.13) | 14.38 ± 1.25 (1.51) | - | - | 4.06 ± 0.04 (2.84) |
U87MG | - | - | 23.58 ± 2.20 | - | - | 34.22 ± 2.74 | 1.06 ± 0.03 |
U87MG.ΔEGFR | - | 27.76 ± 1.86(<0.69) | 16.03 ± 0.88(0.68) | - | - | - (>1.17) | 6.11 ± 0.04 (5.76) |
Hep-G2 | - | - | 23.23 ± 1.67 (1.72) | - | - | - | 1.41 ± 0.12 (<0.04) |
AML12 | - | - | - | - | - | - | - |