Guava pomace: a new source of anti-inflammatory and analgesic bioactives

Table 4 Effect of i.p. administration of guava pomace extract (GPE) on a histamine- and serotonin-induced paw edema

Groups	Dose (mg/kg)	Histamine (1 h)		Serotonin (1 h)
		Mean Edema (∆V mL)	Percent inhibition	Mean Edema (∆V mL)	Percent inhibition
		1 h		1 h
Control		0.12 ± 0.02		0.07 ± 0.02
Cyproheptadine	2	0.04 ± 0.02**	65	0.02 ± 0.02*	65
GPE	300	0.07 ± 0.02*	38	0.02 ± 0.02*	68
GPE	100	0.07 ± 0.01*	41	0.02 ± 0.01*	62
GPE	30	0.13 ± 0.01	-	0.03 ± 0.03	51

∆V = the values represent the mean difference of paw volume between the basal measure and other measure (1 h) ± S.E.M.; n = 5-6. *p < 0.05, **p < 0.01, significantly different when compared to control (ANOVA followed by Dunnett’s test).

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