S. no. | Biochemical parameter | Normal control | STZ-diabetic controla | STZ diabetes+ | STZ diabetes+ | STZ diabetes+ | STZ diabetes+ |
---|---|---|---|---|---|---|---|
MM Ib(100Â mg/kg) | MM IIb(250Â mg/kg) | MM IIIb(500Â mg/kg) | Glibenclamideb(10Â mg/kg) | ||||
1 | Fasting plasma glucose (mg/dL) | 81.8 ± 0.969 | 277 ± 2.608*** | 132.6 ± 1.965* | 108.2 ± 2.922** | 86.2 ± 1.428*** | 90.6 ± 0.509*** |
2 | Fasting Plasma Insulin (μU/mL) | 14.2 ± 0.583 | 3.6 ± 0.509*** | 6.8 ± 0.584* | 10.4 ± 0.601** | 13 ± 0.316*** | 12.6 ± 0.411*** |
3 | Glycated Heamoglobin (A1c) (%) | 1.32 ± 0.073 | 4.86 ± 0.151*** | 3.72 ± 0.081* | 2.96 ± 0.678** | 2.04 ± 0.129*** | 2.16 ± 0.107*** |
4 | Hexokinase (μg/mg of tissue) | 147.8 ± 3.484 | 90.4 ± 3.203*** | 115.6 ± 1.631* | 131 ± 1.871** | 142.6 ± 2.015*** | 140.4 ± 2.182*** |
5 | Glucose-6-Phosphatase (unit/mg of tissue) | 9 ± 0.707 | 14.2 ± 0.583*** | 13.4 ± 0.509* | 11.6 ± 0.611** | 8.6 ± 0.712*** | 9.8 ± 0.567*** |
6 | Fructose-1-6-biphosphatase (unit/mg of tissue) | 28.8 ± 0.861 | 55 ± 1.012*** | 43.8 ± 1.158* | 38.2 ± 1.068** | 30 ± 0.707*** | 31.8 ± 0.861*** |
7 | Total Cholesterol (mg/dl) | 78.2 ± 2.011 | 128 ± 2.366*** | 113.2 ± 2.782* | 101.4 ± 1.631** | 87 ± 1.703*** | 89.2 ± 1.393*** |
8 | Triglycerides (mg/dl) | 81.4 ± 1.327 | 134.8 ± 1.356*** | 115.4 ± 1.077* | 103.6 ± 1.503** | 90 ± 0.707*** | 93.4 ± 1.077*** |
9 | HDL Cholesterol (mg/dL) | 53.2 ± 2.478 | 28.6 ± 2.441*** | 41 ± 1.732* | 44.8 ± 1.158** | 53.8 ± 0.861*** | 52.8 ± 1.655*** |
10 | LDL Cholesterol (mg/dL) | 8.92 ± 2.149 | 72.84 ± 2.812*** | 50.72 ± 3.355* | 34.08 ± 1.979** | 15.4 ± 2.302*** | 19.52 ± 1.547*** |
11 | VLDL Cholesterol (mg/dL) | 16.28 ± 0.265 | 26.96 ± 0.271*** | 23.08 ± 0.215* | 20.72 ± 0.301** | 18 ± 0.141*** | 18.68 ± 0.215*** |
12 | Weight Variation (g) | 192.6 ± 0.872 | 157.8 ± 1.625*** | 189.4 ± 1.032*** | 186.4 ± 1.749*** | 197 ± 1.304*** | 194.2 ± 1.393*** |