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Table 3 Mutagenic activity expressed by the mean number of revertants/plate ± standard deviation and mutagenicity ratio (in brackets) of dichloromethane fraction of C. pallida in S. typhimurium strain (TA98) in the absence (-S9) and in the presence of metabolism (+S9)

From: Estrogenic and mutagenic activities of Crotalaria pallida measured by recombinant yeast assay and Ames test

Dichloromethane fraction of C. pallida

Treatment

TA98

mg/plate

-S9

+S9

DMSO

14 ± 3

27 ± 3

0.3

19 ± 2 (1.4)

29 ± 6 (1.1)

0.9

15 ± 2 (1.1)

27 ± 2 (1.0)

1.7

15 ± 2 (1.1)

29 ± 5 (1.1)

2.6

17 ± 3 (1.2)

33 ± 4 (1.2)

3.4

19 ± 4 (1.4)

31 ± 2 (1.1)

Control+

751 ± 96a

1088 ± 109b

  1. Negative Control: dimethyl sulfoxide (DMSO - 100 μL/plate); Positive Control (Control+); a4-nitro-o-phenylenediamine (10.0 μg/plate); b2-anthramine (1.25 μg/plate).