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Figure 6 | BMC Complementary and Alternative Medicine

Figure 6

From: Paraptosis and NF-κB activation are associated with protopanaxadiol-induced cancer chemoprevention

Figure 6

PPD activated the NF-κB pathway via ROS generation. (A) 24 h after transient transfection of NF-κB reporter plasmids, HCT-116 cells were treated with different concentrations of PPD for 24 h before the luciferase reporter activity was determined. (B) HCT-116 cells were treated with 35 μM of PPD for 24 h in the presence or absence of NAC (10 mM). (C) HCT-116 cells were treated with 35 μM of PPD for 24 h in the presence or absence of PS-1145 (50 μM). Data are presented as the mean ± standard error. **P < 0.01 vs. control; ##P < 0.01 vs. PPD only.

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