TY - JOUR AU - Leung, K. W. AU - Wong, A. S. PY - 2010 DA - 2010// TI - Pharmacology of ginsenosides: a literature review JO - Chin Med VL - 5 UR - https://doi.org/10.1186/1749-8546-5-20 DO - 10.1186/1749-8546-5-20 ID - Leung2010 ER - TY - JOUR AU - Nag, S. A. AU - Qin, J. J. AU - Wang, W. AU - Wang, M. H. AU - Wang, H. AU - Zhang, R. PY - 2012 DA - 2012// TI - Ginsenosides as anticancer agents: In vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action JO - Front Pharmacol VL - 3 UR - https://doi.org/10.3389/fphar.2012.00025 DO - 10.3389/fphar.2012.00025 ID - Nag2012 ER - TY - JOUR AU - Wang, W. AU - Zhao, Y. AU - Rayburn, E. R. AU - Hill, D. L. AU - Wang, H. AU - Zhang, R. PY - 2007 DA - 2007// TI - In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng JO - Cancer Chemother Pharmacol VL - 59 UR - https://doi.org/10.1007/s00280-006-0300-z DO - 10.1007/s00280-006-0300-z ID - Wang2007 ER - TY - CHAP AU - Babina, I. S. AU - Donatello, S. AU - Nabi, I. R. AU - Hopkins, A. M. ED - Gunduz, M. ED - Gunduz, E. PY - 2011 DA - 2011// TI - Lipid Rafts as Master Regulators of Breast Cancer Cell Function BT - Breast cancer - carcinogenesis, cell growth and signalling pathways PB - INTECH CY - New York ID - Babina2011 ER - TY - JOUR AU - George, K. S. AU - Wu, S. PY - 2012 DA - 2012// TI - Lipid raft: a floating island of death or survival JO - Toxicol Appl Pharmacol VL - 259 UR - https://doi.org/10.1016/j.taap.2012.01.007 DO - 10.1016/j.taap.2012.01.007 ID - George2012 ER - TY - JOUR AU - Kabouridis, P. S. AU - Janzen, J. AU - Magee, A. L. AU - Ley, S. C. PY - 2000 DA - 2000// TI - Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes JO - Eur J Immunol VL - 30 UR - https://doi.org/3.0.CO;2-Y DO - 3.0.CO;2-Y ID - Kabouridis2000 ER - TY - JOUR AU - Yi, J. S. AU - Choo, H. J. AU - Cho, B. R. AU - Kim, H. M. AU - Kim, Y. N. AU - Ham, Y. M. AU - Ko, Y. G. PY - 2009 DA - 2009// TI - Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption JO - Biochem Biophys Res Commun VL - 385 UR - https://doi.org/10.1016/j.bbrc.2009.05.028 DO - 10.1016/j.bbrc.2009.05.028 ID - Yi2009 ER - TY - JOUR AU - Park, E. K. AU - Lee, E. J. AU - Lee, S. H. AU - Koo, K. H. AU - Sung, J. Y. AU - Hwang, E. H. AU - Park, J. H. AU - Kim, C. W. AU - Jeong, K. C. AU - Park, B. K. AU - Kim, Y. N. PY - 2010 DA - 2010// TI - Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt JO - Br J Pharmacol VL - 160 UR - https://doi.org/10.1111/j.1476-5381.2010.00768.x DO - 10.1111/j.1476-5381.2010.00768.x ID - Park2010 ER - TY - JOUR AU - Wang, W. AU - Rayburn, E. R. AU - Hao, M. AU - Zhao, Y. AU - Hill, D. L. AU - Zhang, R. AU - Wang, H. PY - 2008 DA - 2008// TI - Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides JO - Prostate VL - 68 UR - https://doi.org/10.1002/pros.20742 DO - 10.1002/pros.20742 ID - Wang2008 ER - TY - JOUR AU - Wang, W. AU - Rayburn, E. R. AU - Hang, J. AU - Zhao, Y. AU - Wang, H. AU - Zhang, R. PY - 2009 DA - 2009// TI - Anti-lung cancer effects of novel ginsenoside 25-OCH(3)-PPD JO - Lung Cancer VL - 65 UR - https://doi.org/10.1016/j.lungcan.2008.11.016 DO - 10.1016/j.lungcan.2008.11.016 ID - Wang2009 ER - TY - JOUR AU - Wang, W. AU - Wang, H. AU - Rayburn, E. R. AU - Zhao, Y. AU - Hill, D. L. AU - Zhang, R. PY - 2008 DA - 2008// TI - 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action JO - Br J Cancer VL - 98 UR - https://doi.org/10.1038/sj.bjc.6604227 DO - 10.1038/sj.bjc.6604227 ID - Wang2008 ER - TY - JOUR AU - Liu, Y. AU - Yang, G. AU - Bu, X. AU - Liu, G. AU - Ding, J. AU - Li, P. AU - Jia, W. PY - 2011 DA - 2011// TI - Cell-type-specific regulation of raft-associated Akt signaling JO - Cell Death Dis VL - 2 UR - https://doi.org/10.1038/cddis.2011.28 DO - 10.1038/cddis.2011.28 ID - Liu2011 ER - TY - JOUR AU - Andrieu-Abadie, N. AU - Jaffrezou, J. P. AU - Hatem, S. AU - Laurent, G. AU - Levade, T. AU - Mercadier, J. J. PY - 1999 DA - 1999// TI - L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation JO - FASEB J VL - 13 ID - Andrieu-Abadie1999 ER - TY - JOUR AU - Kim, H. M. AU - Han, S. B. AU - Kim, M. S. AU - Kang, J. S. AU - Oh, G. T. AU - Hong, D. H. PY - 1996 DA - 1996// TI - Efficient fixation procedure of human leukemia cells in sulforhodamine B cytotoxicity assay JO - J Pharmacol Toxicol Methods VL - 36 UR - https://doi.org/10.1016/S1056-8719(96)00113-X DO - 10.1016/S1056-8719(96)00113-X ID - Kim1996 ER - TY - JOUR AU - Bielawski, J. AU - Szulc, Z. M. AU - Hannun, Y. A. AU - Bielawska, A. PY - 2006 DA - 2006// TI - Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry JO - Methods VL - 39 UR - https://doi.org/10.1016/j.ymeth.2006.05.004 DO - 10.1016/j.ymeth.2006.05.004 ID - Bielawski2006 ER - TY - JOUR AU - Livak, K. J. AU - Schmittgen, T. D. PY - 2001 DA - 2001// TI - Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method JO - Methods VL - 25 UR - https://doi.org/10.1006/meth.2001.1262 DO - 10.1006/meth.2001.1262 ID - Livak2001 ER - TY - JOUR AU - Jost, L. M. AU - Kirkwood, J. M. AU - Whiteside, T. L. PY - 1992 DA - 1992// TI - Improved short- and long-term XTT-based colorimetric cellular cytotoxicity assay for melanoma and other tumor cells JO - J Immunol Methods VL - 147 UR - https://doi.org/10.1016/S0022-1759(12)80003-2 DO - 10.1016/S0022-1759(12)80003-2 ID - Jost1992 ER - TY - JOUR AU - Kim, W. H. AU - Choi, C. H. AU - Kang, S. K. AU - Kwon, C. H. AU - Kim, Y. K. PY - 2005 DA - 2005// TI - Ceramide induces non-apoptotic cell death in human glioma cells JO - Neurochem Res VL - 30 UR - https://doi.org/10.1007/s11064-005-6223-y DO - 10.1007/s11064-005-6223-y ID - Kim2005 ER - TY - JOUR AU - Mondal, S. AU - Mandal, C. AU - Sangwan, R. AU - Chandra, S. PY - 2010 DA - 2010// TI - Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase JO - Mol Cancer VL - 9 ID - Mondal2010 ER - TY - JOUR AU - Luberto, C. AU - Hassler, D. F. AU - Signorelli, P. AU - Okamoto, Y. AU - Sawai, H. AU - Boros, E. AU - Hazen-Martin, D. J. AU - Obeid, L. M. AU - Hannun, Y. A. AU - Smith, G. K. PY - 2002 DA - 2002// TI - Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M206747200 DO - 10.1074/jbc.M206747200 ID - Luberto2002 ER - TY - JOUR AU - Ji, C. AU - Yang, B. AU - Yang, Y. L. AU - He, S. H. AU - Miao, D. S. AU - He, L. AU - Bi, Z. G. PY - 2010 DA - 2010// TI - Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2010.379 DO - 10.1038/onc.2010.379 ID - Ji2010 ER - TY - JOUR AU - Kang, J. H. AU - Song, K. H. AU - Woo, J. K. AU - Park, M. H. AU - Rhee, M. H. AU - Choi, C. AU - Oh, S. H. PY - 2011 DA - 2011// TI - Ginsenoside Rp1 from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells JO - Plant Foods Hum Nutr VL - 66 UR - https://doi.org/10.1007/s11130-011-0242-4 DO - 10.1007/s11130-011-0242-4 ID - Kang2011 ER - TY - JOUR AU - Hong, S. AU - Huo, H. AU - Xu, J. AU - Liao, K. PY - 2004 DA - 2004// TI - Insulin-like growth factor-1 receptor signaling in 3T3-L1 adipocyte differentiation requires lipid rafts but not caveolae JO - Cell Death Differ VL - 11 UR - https://doi.org/10.1038/sj.cdd.4401405 DO - 10.1038/sj.cdd.4401405 ID - Hong2004 ER - TY - JOUR AU - Oh, S. H. AU - Jin, Q. AU - Kim, E. S. AU - Khuri, F. R. AU - Lee, H. Y. PY - 2008 DA - 2008// TI - Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SCH66336 (lonafarnib) through Akt/mammalian target of rapamycin-mediated increases in survivin expression JO - Clin Cancer Res VL - 14 UR - https://doi.org/10.1158/1078-0432.CCR-07-0952 DO - 10.1158/1078-0432.CCR-07-0952 ID - Oh2008 ER - TY - JOUR AU - Werner, H. PY - 2012 DA - 2012// TI - Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer JO - Oncogene VL - 31 UR - https://doi.org/10.1038/onc.2011.447 DO - 10.1038/onc.2011.447 ID - Werner2012 ER - TY - JOUR AU - Gao, Q. G. AU - Chen, W. F. AU - Xie, J. X. AU - Wong, M. S. PY - 2009 DA - 2009// TI - Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways JO - J Neurochem VL - 109 UR - https://doi.org/10.1111/j.1471-4159.2009.06051.x DO - 10.1111/j.1471-4159.2009.06051.x ID - Gao2009 ER - TY - JOUR AU - Li, Q. AU - Li, Y. AU - Wang, X. AU - Fang, X. AU - He, K. AU - Guo, X. AU - Zhan, Z. AU - Sun, C. AU - Jin, Y. H. PY - 2011 DA - 2011// TI - Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release JO - Mol Carcinog VL - 50 UR - https://doi.org/10.1002/mc.20673 DO - 10.1002/mc.20673 ID - Li2011 ER - TY - JOUR AU - Reynolds, C. P. AU - Maurer, B. J. AU - Kolesnick, R. N. PY - 2004 DA - 2004// TI - Ceramide synthesis and metabolism as a target for cancer therapy JO - Cancer Lett VL - 206 UR - https://doi.org/10.1016/j.canlet.2003.08.034 DO - 10.1016/j.canlet.2003.08.034 ID - Reynolds2004 ER - TY - JOUR AU - Marchesini, N. AU - Luberto, C. AU - Hannun, Y. A. PY - 2003 DA - 2003// TI - Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M212262200 DO - 10.1074/jbc.M212262200 ID - Marchesini2003 ER - TY - JOUR AU - Lacour, S. AU - Hammann, A. AU - Grazide, S. AU - Lagadic-Gossmann, D. AU - Athias, A. AU - Sergent, O. AU - Laurent, G. AU - Gambert, P. AU - Solary, E. AU - Dimanche-Boitrel, M. T. PY - 2004 DA - 2004// TI - Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-03-2787 DO - 10.1158/0008-5472.CAN-03-2787 ID - Lacour2004 ER - TY - JOUR AU - Kurinna, S. M. AU - Tsao, C. C. AU - Nica, A. F. AU - Jiffar, T. AU - Ruvolo, P. P. PY - 2004 DA - 2004// TI - Ceramide promotes apoptosis in lung cancer-derived A549 cells by a mechanism involving c-Jun NH2-terminal kinase JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-04-1552 DO - 10.1158/0008-5472.CAN-04-1552 ID - Kurinna2004 ER - TY - JOUR AU - Grammatikos, G. AU - Teichgraber, V. AU - Carpinteiro, A. AU - Trarbach, T. AU - Weller, M. AU - Hengge, U. R. AU - Gulbins, E. PY - 2007 DA - 2007// TI - Overexpression of acid sphingomyelinase sensitizes glioma cells to chemotherapy JO - Antioxid Redox Signal VL - 9 UR - https://doi.org/10.1089/ars.2007.1673 DO - 10.1089/ars.2007.1673 ID - Grammatikos2007 ER - TY - JOUR AU - Cohen, S. M. AU - Mukerji, R. AU - Cai, S. AU - Damjanov, I. AU - Forrest, M. L. AU - Cohen, M. S. PY - 2011 DA - 2011// TI - Subcutaneous delivery of nanoconjugated doxorubicin and cisplatin for locally advanced breast cancer demonstrates improved efficacy and decreased toxicity at lower doses than standard systemic combination therapy in vivo JO - Am J Surg VL - 202 UR - https://doi.org/10.1016/j.amjsurg.2011.06.027 DO - 10.1016/j.amjsurg.2011.06.027 ID - Cohen2011 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/194/prepub UR - http://www.biomedcentral.com/1472-6882/13/194/prepub ID - ref34 ER -