Table 4 MIC of different antibiotics after the association of the extract of Piper nigrum at MIC/2, MIC/5 against eleven MDR bacteria strains
Bacterial strains, MIC (μg/mL ) of antibiotics in the absence and presence of the extract | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Antibiotics | Extract concentration | PA124 | AG100 | AG102 | AG100Atet | CM64 | EA3 | EA27 | EA289 | BM67 | KP55 | NEA16 | PBSS (%) |
TET | 0 | 8 | 16 | 256 | 64 | 8 | 16 | 64 | 16 | 8 | > 256 | 4 | |
MIC/2 | 4(2)S | 16(1)I | ≤ 2(≥ 128)S | 16(4)S | ≤ 2(> 4)S | 4(4)S | 16(4)S | 16(1)I | 8(1)I | > 256 | ≤2(> 2)S | 63.63 | |
MIC/5 | 4(2)S | 16(1)I | ≤ 2(≥ 128)S | 16(4)S | ≤ 2(> 4)S | 4(4)S | 8(8)S | 16(1)I | 8(1)I | > 256 | ≤ 2(> 2)S | 63.63 | |
DOX | 0 | 16 | 8 | 32 | 32 | 32 | 32 | 32 | 32 | 8 | 32 | 64 | na |
MIC/2 | 8(2)S | ≤ 2(> 4)S | ≤ 2(> 16)S | ≤ 2(> 16)S | ≤ 2(> 16)S | 4(8)S | 8(4)S | 32(1)I | ≤ 2(> 4)S | 32(1)I | 4(16)S | 81.81 | |
MIC/5 | 8(2)S | ≤ 2(> 4)S | ≤ 2(> 16)S | ≤ 2(> 16)S | 4(8)S | ≤ 2(> 16)S | 8(4)S | 16(1)I | ≤ 2(> 4)S | 32(1)I | ≤ 2(> 32)S | 81.81 | |
CIP | 0 | 32 | 4 | 128 | 64 | 64 | 128 | ≤ 2 | 8 | 128 | 64 | 128 | na |
MIC/2 | 32(1)I | ≤ 2(> 2)S | 16(8)S | 4(16)S | 8(8)S | 64(2)S | ≤ 2 | 4(2)S | 64(2)S | ≤ 2(> 32)S | 64(2)S | 90 | |
MIC/5 | 32(1)I | ≤ 2(> 2)S | 64(2)S | 16(4)S | 4(16)S | 64(2)S | ≤ 2 | 4(2)S | 128(1)I | ≤ 2(> 32)S | 128(1)I | 70 | |
NFX | 0 | 128 | 128 | 64 | 128 | ≤ 2 | 128 | 32 | 64 | 128 | 128 | 256 | na |
MIC/2 | 64(2)S | 4(32)S | ≤2(> 32)S | 16(8)S | ≤ 2 | 32(4)S | 8(4)S | 16(4)S | 128(1)I | 16(8)S | 128(2)S | 90 | |
MIC/5 | 128(1)I | ≤ 2(> 64)S | 64(1)I | 16(8)S | ≤ 2 | 32(4)S | 16(2)S | 16(4)S | 128(1)I | 16(8)S | 128(2)S | 80 | |
STR | 0 | 256 | ≤ 2 | 256 | 64 | 8 | 32 | 16 | 64 | ≤ 2 | 4 | 64 | na |
MIC/2 | 256(1)I | ≤ 2 | 64(4)S | ≤ 2(> 32)S | ≤ 2(> 4)S | ≤ 2(> 16)S | 32(0.5)I | 4(16)S | ≤ 2 | ≤ 2(> 2)S | ≤ 2(> 32)S | 77.78 | |
MIC/5 | 256(1)I | ≤ 2 | 64(4)S | ≤ 2(> 32)S | ≤ 2(> 4)S | 4(8)S | 16(1)I | 4(16)S | ≤ 2 | ≤ 2(> 2)S | ≤ 2(> 32)S | 77.78 | |
KAN | 0 | ND | 8 | 128 | 32 | ≤2 | 16 | 16 | 32 | ≤ 2 | 8 | ≤ 2 | na |
MIC/2 | ND | ≤ 2(> 4)S | ≤ 2(> 64)S | 16(2)S | ≤2 | ≤ 2(> 8)S | 4(4)S | 4(8)S | ≤ 2 | 16(0.5) | ≤ 2 | 75 | |
MIC/5 | ND | ≤ 2(> 4)S | ≤ 2(> 64)S | 4(8)S | ≤2 | ≤ 2(> 8)S | 4(4)S | 4(8)S | ≤ 2 | 8(1)I | ≤ 2 | 75 | |
CHL | 0 | 32 | 64 | > 256 | 64 | 256 | 32 | > 256 | > 256 | 64 | 16 | 128 | na |
MIC/2 | 16(2)S | 4(16)S | 16(> 16)S | 64(1)I | 32(8)S | 4(8)S | 32(> 8)S | > 256 | 32(2)S | 8(2)S | 8(16)S | 81.81 | |
MIC/5 | 32(1)I | 16(4)S | 16(> 16)S | 64(1)I | 128(2)S | 4(8)S | 64(> 4)S | > 256 | 32(2)S | 16 | 128(1)I | 54.54 | |
ERY | 0 | 128 | 32 | 256 | 128 | > 256 | 256 | 64 | 256 | 256 | 256 | 256 | na |
MIC/2 | 128(1) I | 8(4)S | 64(4)S | 256(0.5)I | 32(> 8)S | 64(4)S | 32(2)S | 256(1)I | 64(4)S | 16(16)S | 64(4)S | 72.72 | |
MIC/5 | 128(1)I | 16(2)S | 32(4)S | 128(1)I | 8(> 32)S | 256(1)I | 8(8)S | 256(1)I | 128(2)S | 16(16)S | 64(4)S | 63.63 | |
AMP | 0 | 128 | 128 | > 256 | > 256 | > 256 | > 256 | > 256 | >256 | > 256 | > 256 | > 256 | na |
MIC/2 | 128(1)I | 128(1)I | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | na | |
MIC/5 | 128(1)I | 128(1)I | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | na | |
FEP | 0 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | na |
MIC/2 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | na | |
MIC/5 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | >256 | > 256 | > 256 | > 256 | na | |
CLX | 0 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | na |
MIC/2 | > 256 | 16(> 16)S | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | 1.1 | |
MIC/5 | > 256 | 32(> 8)S | > 256 | > 256 | 64(> 4)S | > 256 | > 256 | > 256 | > 256 | > 256 | > 256 | 18.2 | |