Figure 4
Effects of GTPs on the distribution and expression of claudin-5, occludin, and ZO-1 in ischemic cerebral microvessels were analyzed by immunohistochemistry at 0, 30, 60 and 120 min after ischemia. Representative immunohistochemistry stained graphs of claudin-5 (A, C, E, G), occludin (I, K, M, O), and ZO-1 (Q, S, U, W) at 0, 30, 60, and 120 min after ischemia in the vehicle group; graphs of claudin-5 (B, D, F, H), occludin (J, L, N, P), and ZO-1 (R, T, V, X) at 0, 30, 60, and 120 min after ischemia in the GTPs-treated group. Arrows show cerebral microvessels. Scale bar = 10 μm.