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Table 4 Serum biochemical values in rats orally treated with HZJW

From: Gastroprotective and anti-Helicobacter pylori potential of herbal formula HZJW: safety and efficacy assessment

Parameter unit sex Dose (mg/kg)
  0 mg/kg 1000 mg/kg 2500 mg/kg 5000 mg/kg
  13 wk 26 wk Recovery 13 wk 26 wk Recovery 13 wk 26 wk Recovery 13wk 26 wk Recovery
ALT U/L Male 40 ± 3 39 ± 11 34 ± 8 31 ± 8 42 ± 11 34 ± 12 41 ± 4 34 ± 10 47 ± 14 41 ± 10 30 ± 6 37 ± 9
Female 43 ± 8 44 ± 22 32 ± 8 29 ± 8* 59 ± 32 39 ± 26 33 ± 9 39 ± 23 41 ± 43 27 ± 4** 28 ± 6 28 ± 7
AST U/L Male 161 ± 6 109 ± 28 80 ± 15 114 ± 24** 113 ± 36 91 ± 40 124 ± 13** 83 ± 13 112 ± 21 121 ± 20** 87 ± 25 105 ± 21
Female 161 ± 35 122 ± 81 78 ± 17 113 ± 18* 155 ± 72 100 ± 42 127 ± 27 104 ± 45 86 ± 71 98 ± 14** 81 ± 20 65 ± 12
LP U/L Male 90 ± 10 106 ± 38 77 ± 27 105 ± 29 70 ± 15 80 ± 43 106 ± 27 79 ± 21 84 ± 14 98 ± 22 68 ± 20 93 ± 15
Female 61 ± 19 51 ± 15 59 ± 17 60 ± 11 46 ± 18 48 ± 17 55 ± 23 54 ± 11 41 ± 22 55 ± 23 44 ± 15 57 ± 19
GLU mmol/L Male 7.26 ± 0.73 6.07 ± 0.78 7.89 ± 1.27 6.99 ± 1.49 6.69 ± 0.75 7.85 ± 1.03 6.27 ± 0.68 7.84 ± 1.30 7.48 ± 0.84 7.38 ± 0.78 8.39 ± 0.78** 8.55 ± 1.22
Female 7.60 ± 0.95 6.57 ± 0.80 7.10 ± 0.36 7.04 ± 0.83 6.81 ± 0.60 6.61 ± 0.56 6.35 ± 1.27 6.45 ± 0.63 7.02 ± 0.43 7.66 ± 1.33 7.48 ± 1.05 7.30 ± 0.35
CHOL mmol/L Male 1.20 ± 0.26 1.53 ± 0.28 1.63 ± 0.21 1.34 ± 0.33 1.44 ± 0.35 1.41 ± 0.10 1.58 ± 0.26 1.53 ± 0.36 1.73 ± 0.13 1.81 ± 0.36 1.46 ± 0.10 1.35 ± 0.21
Female 1.77 ± 0.38 2.20 ± 0.38 1.97 ± 0.47 2.14 ± 0.31 2.33 ± 0.42 2.46 ± 1.10 2.23 ± 0.39 2.25 ± 0.56 2.20 ± 0.46 2.07 ± 0.38 2.08 ± 0.44 1.92 ± 0.53
TG mmol/L Male 0.50 ± 0.06 0.66 ± 0.20 0.74 ± 0.73 0.90 ± 0.45 0.84 ± 0.36 0.85 ± 0.27 0.84 ± 0.36 0.92 ± 0.39 0.65 ± 0.16 0.74 ± 0.03** 1.01 ± 0.39* 0.74 ± 0.41
Female 0.62 ± 0.08 1.18 ± 0.62 0.70 ± 0.46 0.70 ± 0.13 0.92 ± 0.50 0.85 ± 0.28 0.58 ± 0.11 0.51 ± 0.12 0.61 ± 0.25 0.84 ± 0.32 0.75 ± 0.25 0.59 ± 0.20
TP g/L Male 5.29 ± 0.12 5.36 ± 0.29 5.54 ± 0.25 5.34 ± 0.25 5.50 ± 0.47 5.45 ± 0.18 5.70 ± 0.19** 5.37 ± 0.51 5.50 ± 0.19 5.84 ± 0.13** 5.45 ± 0.38 5.67 ± 0.22
Female 5.93 ± 0.22 6.34 ± 0.27 6.32 ± 0.42 6.31 ± 0.48 6.72 ± 0.50 6.81 ± 0.33 6.39 ± 0.27* 6.37 ± 0.43 6.32 ± 0.26 6.48 ± 0.26** 6.49 ± 0.50 6.22 ± 0.27
ALB g/L Male 3.02 ± 0.08 2.83 ± 0.34 3.04 ± 0.15 2.99 ± 0.21 2.92 ± 0.40 3.12 ± 0.13 3.33 ± 0.15** 2.86 ± 0.45 3.18 ± 0.06 3.37 ± 0.11** 2.95 ± 0.41 3.09 ± 0.13
Female 3.50 ± 0.22 3.63 ± 0.30 3.78 ± 0.35 3.69 ± 0.28 3.83 ± 0.31 4.00 ± 0.15 3.65 ± 0.19 3.64 ± 0.30 3.70 ± 0.26 3.87 ± 0.22* 3.61 ± 0.38 3.71 ± 0.17
T-BIL μmol/L Male 3.4 ± 0.4 2.9 ± 1.6 3.0 ± 2.5 3.8 ± 0.9 3.0 ± 0.7 2.4 ± 0.5 3.1 ± 0.9 3.1 ± 0.6 2.0 ± 0.4 3.5 ± 0.8 2.9 ± 1.2 2.6 ± 1.1
Female 3.9 ± 0.5 4.1 ± 1.4 3.0 ± 0.8 3.0 ± 0.7 3.6 ± 0.8 3.7 ± 0.9 3.7 ± 1.0 2.7 ± 0.6* 2.7 ± 0.5 3.1 ± 0.7 3.9 ± 0.8 2.8 ± 0.5
D-BIL μmol/L Male 2.4 ± 0.4 1.4 ± 0.5 1.8 ± 0.6 2.2 ± 0.6 1.2 ± 0.5 1.7 ± 0.2 1.2 ± 0.4 1.0 ± 0.4 1.4 ± 0.1 1.3 ± 0.6 1.1 ± 0.9 1.6 ± 0.5
Female 2.5 ± 0.1 2.0 ± 1.0 1.9 ± 0.4 1.5 ± 0.3 1.5 ± 0.6 2.5 ± 0.4 1.8 ± 0.7 0.9 ± 0.4** 1.9 ± 0.3 0.9 ± 0.2 1.4 ± 0.9 1.8 ± 0.3
Cre μmol/L Male 70.3 ± 4.6 63.6 ± 9.5 65.2 ± 10.3 74.7 ± 9.0 64.8 ± 11.9 56.1 ± 4.8 80.3 ± 10.0 62.9 ± 10.3 73.3 ± 11.8 80.5 ± 4.6 64.7 ± 4.1 76.2 ± 2.7
Female 78.8 ± 5.9 68.2 ± 8.1 67.3 ± 7.2 79.4 ± 5.2 66.9 ± 5.1 65.5 ± 3.4 82.6 ± 6.4 67.1 ± 5.7 63.2 ± 1.1 78.8 ± 8.9 71.4 ± 7.7 66.7 ± 5.3
CPK U/L Male 3214 ± 597 335 ± 141 183 ± 47 767 ± 931 325 ± 324 150 ± 46 404 ± 61 218 ± 119 301 ± 38 509 ± 220 245 ± 111 362 ± 130
Female 2032 ± 1363 244 ± 61 168 ± 89 801 ± 616 248 ± 173 231 ± 123 488 ± 143 277 ± 133 120 ± 54 264 ± 51 158 ± 44 111 ± 34
Ure mmol/L Male 4.85 ± 0.26 5.77 ± 0.82 5.17 ± 1.00 4.57 ± 0.44 5.53 ± 1.22 5.35 ± 0.66 4.23 ± 0.65 5.88 ± 0.73 5.93 ± 0.39 4.33 ± 0.43 5.66 ± 1.08 6.02 ± 1.44
Female 5.44 ± 0.49 6.08 ± 0.73 6.32 ± 0.89 5.04 ± 0.51 6.04 ± 0.92 6.13 ± 1.01 5.42 ± 0.59 6.72 ± 1.11 6.45 ± 0.67 5.71 ± 0.87 6.74 ± 1.31** 6.24 ± 1.12
Na+ mmol/L Male 141.3 ± 0.7 141.8 ± 1.4 142.3 ± 0.2 141.0 ± 0.4 142.4 ± 1.6 142.3 ± 1.2 140.7 ± 1.3 141.2 ± 0.7 141.9 ± 1.5 139.8 ± 0.7 141.1 ± 1.4 141.1 ± 0.8
Female 141.6 ± 0.9 140.0 ± 1.9 141.8 ± 0.9 140.9 ± 1.0 140.9 ± 0.9 143.0 ± 0.6 140.3 ± 1.0 141.0 ± 1.7 142.6 ± 1.4 139.4 ± 1.0 139.8 ± 0.8 142.5 ± 0.7
K+ mmol/L Male 4.81 ± 0.27 3.95 ± 0.27 3.65 ± 0.20 5.02 ± 0.43 4.08 ± 0.64 3.50 ± 0.28 5.16 ± 0.32 4.15 ± 0.70 3.90 ± 0.20 5.13 ± 0.12 3.92 ± 0.56 4.09 ± 0.27
Female 4.43 ± 0.25 3.86 ± 0.33 3.43 ± 0.36 4.80 ± 0.34 3.57 ± 0.20 3.42 ± 0.08 4.60 ± 0.37 3.59 ± 0.27 3.46 ± 0.21 4.99 ± 0.54 4.57 ± 2.02 3.33 ± 0.31
Cl- mmol/L Male 111.1 ± 0.4 108.7 ± 2.9 107.0 ± 2.2 110.3 ± 0.9 106.7 ± 1.5 109.5 ± 1.6 108.2 ± 1.3 108.0 ± 2.9 107.2 ± 0.5 106.4 ± 1.6 107.6 ± 2.2 106.5 ± 1.2
   Female 110.3 ± 3.3 108.9 ± 2.3 109.8 ± 1.6 109.7 ± 2.1 110.7 ± 1.4 109.8 ± 0.8 109.8 ± 1.6 109.2 ± 2.8 109.6 ± 1.2 107.3 ± 1.2 106.7 ± 1.6 109.1 ± 1.1
  1. Note: Aspartate aminotransferase activity (AST), alanine aminotransferase activity (ALT), alkaline phosphatase activity (ALP), albumin (ALB), total protein (TP), glucose (GLU), total cholesterol (CHOL), creatine phosphokinase activity (CPK), total bilirubin (T-BIL), direct bilirubin (D-BIL), creatinine (CRE), triglycerides (TG), urea (Ure), sodium ions (Na+), potassium ions (K+), chlorideions (Cl-). Values are mean ± S.D. (n = 5 (4 weeks), 10 (26 weeks) or recovery (30 weeks)/sex/dose). * P < 0.05 & ** P < 0.01 compared with normal group.