Parameter unit sex | Dose (mg/kg) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | 0 mg/kg | 1000 mg/kg | 2500 mg/kg | 5000 mg/kg | ||||||||||
 | 13 wk | 26 wk | Recovery | 13 wk | 26 wk | Recovery | 13 wk | 26 wk | Recovery | 13wk | 26 wk | Recovery | ||
ALT | U/L | Male | 40 ± 3 | 39 ± 11 | 34 ± 8 | 31 ± 8 | 42 ± 11 | 34 ± 12 | 41 ± 4 | 34 ± 10 | 47 ± 14 | 41 ± 10 | 30 ± 6 | 37 ± 9 |
Female | 43 ± 8 | 44 ± 22 | 32 ± 8 | 29 ± 8* | 59 ± 32 | 39 ± 26 | 33 ± 9 | 39 ± 23 | 41 ± 43 | 27 ± 4** | 28 ± 6 | 28 ± 7 | ||
AST | U/L | Male | 161 ± 6 | 109 ± 28 | 80 ± 15 | 114 ± 24** | 113 ± 36 | 91 ± 40 | 124 ± 13** | 83 ± 13 | 112 ± 21 | 121 ± 20** | 87 ± 25 | 105 ± 21 |
Female | 161 ± 35 | 122 ± 81 | 78 ± 17 | 113 ± 18* | 155 ± 72 | 100 ± 42 | 127 ± 27 | 104 ± 45 | 86 ± 71 | 98 ± 14** | 81 ± 20 | 65 ± 12 | ||
LP | U/L | Male | 90 ± 10 | 106 ± 38 | 77 ± 27 | 105 ± 29 | 70 ± 15 | 80 ± 43 | 106 ± 27 | 79 ± 21 | 84 ± 14 | 98 ± 22 | 68 ± 20 | 93 ± 15 |
Female | 61 ± 19 | 51 ± 15 | 59 ± 17 | 60 ± 11 | 46 ± 18 | 48 ± 17 | 55 ± 23 | 54 ± 11 | 41 ± 22 | 55 ± 23 | 44 ± 15 | 57 ± 19 | ||
GLU | mmol/L | Male | 7.26 ± 0.73 | 6.07 ± 0.78 | 7.89 ± 1.27 | 6.99 ± 1.49 | 6.69 ± 0.75 | 7.85 ± 1.03 | 6.27 ± 0.68 | 7.84 ± 1.30 | 7.48 ± 0.84 | 7.38 ± 0.78 | 8.39 ± 0.78** | 8.55 ± 1.22 |
Female | 7.60 ± 0.95 | 6.57 ± 0.80 | 7.10 ± 0.36 | 7.04 ± 0.83 | 6.81 ± 0.60 | 6.61 ± 0.56 | 6.35 ± 1.27 | 6.45 ± 0.63 | 7.02 ± 0.43 | 7.66 ± 1.33 | 7.48 ± 1.05 | 7.30 ± 0.35 | ||
CHOL | mmol/L | Male | 1.20 ± 0.26 | 1.53 ± 0.28 | 1.63 ± 0.21 | 1.34 ± 0.33 | 1.44 ± 0.35 | 1.41 ± 0.10 | 1.58 ± 0.26 | 1.53 ± 0.36 | 1.73 ± 0.13 | 1.81 ± 0.36 | 1.46 ± 0.10 | 1.35 ± 0.21 |
Female | 1.77 ± 0.38 | 2.20 ± 0.38 | 1.97 ± 0.47 | 2.14 ± 0.31 | 2.33 ± 0.42 | 2.46 ± 1.10 | 2.23 ± 0.39 | 2.25 ± 0.56 | 2.20 ± 0.46 | 2.07 ± 0.38 | 2.08 ± 0.44 | 1.92 ± 0.53 | ||
TG | mmol/L | Male | 0.50 ± 0.06 | 0.66 ± 0.20 | 0.74 ± 0.73 | 0.90 ± 0.45 | 0.84 ± 0.36 | 0.85 ± 0.27 | 0.84 ± 0.36 | 0.92 ± 0.39 | 0.65 ± 0.16 | 0.74 ± 0.03** | 1.01 ± 0.39* | 0.74 ± 0.41 |
Female | 0.62 ± 0.08 | 1.18 ± 0.62 | 0.70 ± 0.46 | 0.70 ± 0.13 | 0.92 ± 0.50 | 0.85 ± 0.28 | 0.58 ± 0.11 | 0.51 ± 0.12 | 0.61 ± 0.25 | 0.84 ± 0.32 | 0.75 ± 0.25 | 0.59 ± 0.20 | ||
TP | g/L | Male | 5.29 ± 0.12 | 5.36 ± 0.29 | 5.54 ± 0.25 | 5.34 ± 0.25 | 5.50 ± 0.47 | 5.45 ± 0.18 | 5.70 ± 0.19** | 5.37 ± 0.51 | 5.50 ± 0.19 | 5.84 ± 0.13** | 5.45 ± 0.38 | 5.67 ± 0.22 |
Female | 5.93 ± 0.22 | 6.34 ± 0.27 | 6.32 ± 0.42 | 6.31 ± 0.48 | 6.72 ± 0.50 | 6.81 ± 0.33 | 6.39 ± 0.27* | 6.37 ± 0.43 | 6.32 ± 0.26 | 6.48 ± 0.26** | 6.49 ± 0.50 | 6.22 ± 0.27 | ||
ALB | g/L | Male | 3.02 ± 0.08 | 2.83 ± 0.34 | 3.04 ± 0.15 | 2.99 ± 0.21 | 2.92 ± 0.40 | 3.12 ± 0.13 | 3.33 ± 0.15** | 2.86 ± 0.45 | 3.18 ± 0.06 | 3.37 ± 0.11** | 2.95 ± 0.41 | 3.09 ± 0.13 |
Female | 3.50 ± 0.22 | 3.63 ± 0.30 | 3.78 ± 0.35 | 3.69 ± 0.28 | 3.83 ± 0.31 | 4.00 ± 0.15 | 3.65 ± 0.19 | 3.64 ± 0.30 | 3.70 ± 0.26 | 3.87 ± 0.22* | 3.61 ± 0.38 | 3.71 ± 0.17 | ||
T-BIL | μmol/L | Male | 3.4 ± 0.4 | 2.9 ± 1.6 | 3.0 ± 2.5 | 3.8 ± 0.9 | 3.0 ± 0.7 | 2.4 ± 0.5 | 3.1 ± 0.9 | 3.1 ± 0.6 | 2.0 ± 0.4 | 3.5 ± 0.8 | 2.9 ± 1.2 | 2.6 ± 1.1 |
Female | 3.9 ± 0.5 | 4.1 ± 1.4 | 3.0 ± 0.8 | 3.0 ± 0.7 | 3.6 ± 0.8 | 3.7 ± 0.9 | 3.7 ± 1.0 | 2.7 ± 0.6* | 2.7 ± 0.5 | 3.1 ± 0.7 | 3.9 ± 0.8 | 2.8 ± 0.5 | ||
D-BIL | μmol/L | Male | 2.4 ± 0.4 | 1.4 ± 0.5 | 1.8 ± 0.6 | 2.2 ± 0.6 | 1.2 ± 0.5 | 1.7 ± 0.2 | 1.2 ± 0.4 | 1.0 ± 0.4 | 1.4 ± 0.1 | 1.3 ± 0.6 | 1.1 ± 0.9 | 1.6 ± 0.5 |
Female | 2.5 ± 0.1 | 2.0 ± 1.0 | 1.9 ± 0.4 | 1.5 ± 0.3 | 1.5 ± 0.6 | 2.5 ± 0.4 | 1.8 ± 0.7 | 0.9 ± 0.4** | 1.9 ± 0.3 | 0.9 ± 0.2 | 1.4 ± 0.9 | 1.8 ± 0.3 | ||
Cre | μmol/L | Male | 70.3 ± 4.6 | 63.6 ± 9.5 | 65.2 ± 10.3 | 74.7 ± 9.0 | 64.8 ± 11.9 | 56.1 ± 4.8 | 80.3 ± 10.0 | 62.9 ± 10.3 | 73.3 ± 11.8 | 80.5 ± 4.6 | 64.7 ± 4.1 | 76.2 ± 2.7 |
Female | 78.8 ± 5.9 | 68.2 ± 8.1 | 67.3 ± 7.2 | 79.4 ± 5.2 | 66.9 ± 5.1 | 65.5 ± 3.4 | 82.6 ± 6.4 | 67.1 ± 5.7 | 63.2 ± 1.1 | 78.8 ± 8.9 | 71.4 ± 7.7 | 66.7 ± 5.3 | ||
CPK | U/L | Male | 3214 ± 597 | 335 ± 141 | 183 ± 47 | 767 ± 931 | 325 ± 324 | 150 ± 46 | 404 ± 61 | 218 ± 119 | 301 ± 38 | 509 ± 220 | 245 ± 111 | 362 ± 130 |
Female | 2032 ± 1363 | 244 ± 61 | 168 ± 89 | 801 ± 616 | 248 ± 173 | 231 ± 123 | 488 ± 143 | 277 ± 133 | 120 ± 54 | 264 ± 51 | 158 ± 44 | 111 ± 34 | ||
Ure | mmol/L | Male | 4.85 ± 0.26 | 5.77 ± 0.82 | 5.17 ± 1.00 | 4.57 ± 0.44 | 5.53 ± 1.22 | 5.35 ± 0.66 | 4.23 ± 0.65 | 5.88 ± 0.73 | 5.93 ± 0.39 | 4.33 ± 0.43 | 5.66 ± 1.08 | 6.02 ± 1.44 |
Female | 5.44 ± 0.49 | 6.08 ± 0.73 | 6.32 ± 0.89 | 5.04 ± 0.51 | 6.04 ± 0.92 | 6.13 ± 1.01 | 5.42 ± 0.59 | 6.72 ± 1.11 | 6.45 ± 0.67 | 5.71 ± 0.87 | 6.74 ± 1.31** | 6.24 ± 1.12 | ||
Na+ | mmol/L | Male | 141.3 ± 0.7 | 141.8 ± 1.4 | 142.3 ± 0.2 | 141.0 ± 0.4 | 142.4 ± 1.6 | 142.3 ± 1.2 | 140.7 ± 1.3 | 141.2 ± 0.7 | 141.9 ± 1.5 | 139.8 ± 0.7 | 141.1 ± 1.4 | 141.1 ± 0.8 |
Female | 141.6 ± 0.9 | 140.0 ± 1.9 | 141.8 ± 0.9 | 140.9 ± 1.0 | 140.9 ± 0.9 | 143.0 ± 0.6 | 140.3 ± 1.0 | 141.0 ± 1.7 | 142.6 ± 1.4 | 139.4 ± 1.0 | 139.8 ± 0.8 | 142.5 ± 0.7 | ||
K+ | mmol/L | Male | 4.81 ± 0.27 | 3.95 ± 0.27 | 3.65 ± 0.20 | 5.02 ± 0.43 | 4.08 ± 0.64 | 3.50 ± 0.28 | 5.16 ± 0.32 | 4.15 ± 0.70 | 3.90 ± 0.20 | 5.13 ± 0.12 | 3.92 ± 0.56 | 4.09 ± 0.27 |
Female | 4.43 ± 0.25 | 3.86 ± 0.33 | 3.43 ± 0.36 | 4.80 ± 0.34 | 3.57 ± 0.20 | 3.42 ± 0.08 | 4.60 ± 0.37 | 3.59 ± 0.27 | 3.46 ± 0.21 | 4.99 ± 0.54 | 4.57 ± 2.02 | 3.33 ± 0.31 | ||
Cl- | mmol/L | Male | 111.1 ± 0.4 | 108.7 ± 2.9 | 107.0 ± 2.2 | 110.3 ± 0.9 | 106.7 ± 1.5 | 109.5 ± 1.6 | 108.2 ± 1.3 | 108.0 ± 2.9 | 107.2 ± 0.5 | 106.4 ± 1.6 | 107.6 ± 2.2 | 106.5 ± 1.2 |
 |  | Female | 110.3 ± 3.3 | 108.9 ± 2.3 | 109.8 ± 1.6 | 109.7 ± 2.1 | 110.7 ± 1.4 | 109.8 ± 0.8 | 109.8 ± 1.6 | 109.2 ± 2.8 | 109.6 ± 1.2 | 107.3 ± 1.2 | 106.7 ± 1.6 | 109.1 ± 1.1 |