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Table 4 Serum biochemical values in rats orally treated with HZJW

From: Gastroprotective and anti-Helicobacter pylori potential of herbal formula HZJW: safety and efficacy assessment

Parameter unit sex

Dose (mg/kg)

 

0 mg/kg

1000 mg/kg

2500 mg/kg

5000 mg/kg

 

13 wk

26 wk

Recovery

13 wk

26 wk

Recovery

13 wk

26 wk

Recovery

13wk

26 wk

Recovery

ALT

U/L

Male

40 ± 3

39 ± 11

34 ± 8

31 ± 8

42 ± 11

34 ± 12

41 ± 4

34 ± 10

47 ± 14

41 ± 10

30 ± 6

37 ± 9

Female

43 ± 8

44 ± 22

32 ± 8

29 ± 8*

59 ± 32

39 ± 26

33 ± 9

39 ± 23

41 ± 43

27 ± 4**

28 ± 6

28 ± 7

AST

U/L

Male

161 ± 6

109 ± 28

80 ± 15

114 ± 24**

113 ± 36

91 ± 40

124 ± 13**

83 ± 13

112 ± 21

121 ± 20**

87 ± 25

105 ± 21

Female

161 ± 35

122 ± 81

78 ± 17

113 ± 18*

155 ± 72

100 ± 42

127 ± 27

104 ± 45

86 ± 71

98 ± 14**

81 ± 20

65 ± 12

LP

U/L

Male

90 ± 10

106 ± 38

77 ± 27

105 ± 29

70 ± 15

80 ± 43

106 ± 27

79 ± 21

84 ± 14

98 ± 22

68 ± 20

93 ± 15

Female

61 ± 19

51 ± 15

59 ± 17

60 ± 11

46 ± 18

48 ± 17

55 ± 23

54 ± 11

41 ± 22

55 ± 23

44 ± 15

57 ± 19

GLU

mmol/L

Male

7.26 ± 0.73

6.07 ± 0.78

7.89 ± 1.27

6.99 ± 1.49

6.69 ± 0.75

7.85 ± 1.03

6.27 ± 0.68

7.84 ± 1.30

7.48 ± 0.84

7.38 ± 0.78

8.39 ± 0.78**

8.55 ± 1.22

Female

7.60 ± 0.95

6.57 ± 0.80

7.10 ± 0.36

7.04 ± 0.83

6.81 ± 0.60

6.61 ± 0.56

6.35 ± 1.27

6.45 ± 0.63

7.02 ± 0.43

7.66 ± 1.33

7.48 ± 1.05

7.30 ± 0.35

CHOL

mmol/L

Male

1.20 ± 0.26

1.53 ± 0.28

1.63 ± 0.21

1.34 ± 0.33

1.44 ± 0.35

1.41 ± 0.10

1.58 ± 0.26

1.53 ± 0.36

1.73 ± 0.13

1.81 ± 0.36

1.46 ± 0.10

1.35 ± 0.21

Female

1.77 ± 0.38

2.20 ± 0.38

1.97 ± 0.47

2.14 ± 0.31

2.33 ± 0.42

2.46 ± 1.10

2.23 ± 0.39

2.25 ± 0.56

2.20 ± 0.46

2.07 ± 0.38

2.08 ± 0.44

1.92 ± 0.53

TG

mmol/L

Male

0.50 ± 0.06

0.66 ± 0.20

0.74 ± 0.73

0.90 ± 0.45

0.84 ± 0.36

0.85 ± 0.27

0.84 ± 0.36

0.92 ± 0.39

0.65 ± 0.16

0.74 ± 0.03**

1.01 ± 0.39*

0.74 ± 0.41

Female

0.62 ± 0.08

1.18 ± 0.62

0.70 ± 0.46

0.70 ± 0.13

0.92 ± 0.50

0.85 ± 0.28

0.58 ± 0.11

0.51 ± 0.12

0.61 ± 0.25

0.84 ± 0.32

0.75 ± 0.25

0.59 ± 0.20

TP

g/L

Male

5.29 ± 0.12

5.36 ± 0.29

5.54 ± 0.25

5.34 ± 0.25

5.50 ± 0.47

5.45 ± 0.18

5.70 ± 0.19**

5.37 ± 0.51

5.50 ± 0.19

5.84 ± 0.13**

5.45 ± 0.38

5.67 ± 0.22

Female

5.93 ± 0.22

6.34 ± 0.27

6.32 ± 0.42

6.31 ± 0.48

6.72 ± 0.50

6.81 ± 0.33

6.39 ± 0.27*

6.37 ± 0.43

6.32 ± 0.26

6.48 ± 0.26**

6.49 ± 0.50

6.22 ± 0.27

ALB

g/L

Male

3.02 ± 0.08

2.83 ± 0.34

3.04 ± 0.15

2.99 ± 0.21

2.92 ± 0.40

3.12 ± 0.13

3.33 ± 0.15**

2.86 ± 0.45

3.18 ± 0.06

3.37 ± 0.11**

2.95 ± 0.41

3.09 ± 0.13

Female

3.50 ± 0.22

3.63 ± 0.30

3.78 ± 0.35

3.69 ± 0.28

3.83 ± 0.31

4.00 ± 0.15

3.65 ± 0.19

3.64 ± 0.30

3.70 ± 0.26

3.87 ± 0.22*

3.61 ± 0.38

3.71 ± 0.17

T-BIL

μmol/L

Male

3.4 ± 0.4

2.9 ± 1.6

3.0 ± 2.5

3.8 ± 0.9

3.0 ± 0.7

2.4 ± 0.5

3.1 ± 0.9

3.1 ± 0.6

2.0 ± 0.4

3.5 ± 0.8

2.9 ± 1.2

2.6 ± 1.1

Female

3.9 ± 0.5

4.1 ± 1.4

3.0 ± 0.8

3.0 ± 0.7

3.6 ± 0.8

3.7 ± 0.9

3.7 ± 1.0

2.7 ± 0.6*

2.7 ± 0.5

3.1 ± 0.7

3.9 ± 0.8

2.8 ± 0.5

D-BIL

μmol/L

Male

2.4 ± 0.4

1.4 ± 0.5

1.8 ± 0.6

2.2 ± 0.6

1.2 ± 0.5

1.7 ± 0.2

1.2 ± 0.4

1.0 ± 0.4

1.4 ± 0.1

1.3 ± 0.6

1.1 ± 0.9

1.6 ± 0.5

Female

2.5 ± 0.1

2.0 ± 1.0

1.9 ± 0.4

1.5 ± 0.3

1.5 ± 0.6

2.5 ± 0.4

1.8 ± 0.7

0.9 ± 0.4**

1.9 ± 0.3

0.9 ± 0.2

1.4 ± 0.9

1.8 ± 0.3

Cre

μmol/L

Male

70.3 ± 4.6

63.6 ± 9.5

65.2 ± 10.3

74.7 ± 9.0

64.8 ± 11.9

56.1 ± 4.8

80.3 ± 10.0

62.9 ± 10.3

73.3 ± 11.8

80.5 ± 4.6

64.7 ± 4.1

76.2 ± 2.7

Female

78.8 ± 5.9

68.2 ± 8.1

67.3 ± 7.2

79.4 ± 5.2

66.9 ± 5.1

65.5 ± 3.4

82.6 ± 6.4

67.1 ± 5.7

63.2 ± 1.1

78.8 ± 8.9

71.4 ± 7.7

66.7 ± 5.3

CPK

U/L

Male

3214 ± 597

335 ± 141

183 ± 47

767 ± 931

325 ± 324

150 ± 46

404 ± 61

218 ± 119

301 ± 38

509 ± 220

245 ± 111

362 ± 130

Female

2032 ± 1363

244 ± 61

168 ± 89

801 ± 616

248 ± 173

231 ± 123

488 ± 143

277 ± 133

120 ± 54

264 ± 51

158 ± 44

111 ± 34

Ure

mmol/L

Male

4.85 ± 0.26

5.77 ± 0.82

5.17 ± 1.00

4.57 ± 0.44

5.53 ± 1.22

5.35 ± 0.66

4.23 ± 0.65

5.88 ± 0.73

5.93 ± 0.39

4.33 ± 0.43

5.66 ± 1.08

6.02 ± 1.44

Female

5.44 ± 0.49

6.08 ± 0.73

6.32 ± 0.89

5.04 ± 0.51

6.04 ± 0.92

6.13 ± 1.01

5.42 ± 0.59

6.72 ± 1.11

6.45 ± 0.67

5.71 ± 0.87

6.74 ± 1.31**

6.24 ± 1.12

Na+

mmol/L

Male

141.3 ± 0.7

141.8 ± 1.4

142.3 ± 0.2

141.0 ± 0.4

142.4 ± 1.6

142.3 ± 1.2

140.7 ± 1.3

141.2 ± 0.7

141.9 ± 1.5

139.8 ± 0.7

141.1 ± 1.4

141.1 ± 0.8

Female

141.6 ± 0.9

140.0 ± 1.9

141.8 ± 0.9

140.9 ± 1.0

140.9 ± 0.9

143.0 ± 0.6

140.3 ± 1.0

141.0 ± 1.7

142.6 ± 1.4

139.4 ± 1.0

139.8 ± 0.8

142.5 ± 0.7

K+

mmol/L

Male

4.81 ± 0.27

3.95 ± 0.27

3.65 ± 0.20

5.02 ± 0.43

4.08 ± 0.64

3.50 ± 0.28

5.16 ± 0.32

4.15 ± 0.70

3.90 ± 0.20

5.13 ± 0.12

3.92 ± 0.56

4.09 ± 0.27

Female

4.43 ± 0.25

3.86 ± 0.33

3.43 ± 0.36

4.80 ± 0.34

3.57 ± 0.20

3.42 ± 0.08

4.60 ± 0.37

3.59 ± 0.27

3.46 ± 0.21

4.99 ± 0.54

4.57 ± 2.02

3.33 ± 0.31

Cl-

mmol/L

Male

111.1 ± 0.4

108.7 ± 2.9

107.0 ± 2.2

110.3 ± 0.9

106.7 ± 1.5

109.5 ± 1.6

108.2 ± 1.3

108.0 ± 2.9

107.2 ± 0.5

106.4 ± 1.6

107.6 ± 2.2

106.5 ± 1.2

  

Female

110.3 ± 3.3

108.9 ± 2.3

109.8 ± 1.6

109.7 ± 2.1

110.7 ± 1.4

109.8 ± 0.8

109.8 ± 1.6

109.2 ± 2.8

109.6 ± 1.2

107.3 ± 1.2

106.7 ± 1.6

109.1 ± 1.1

  1. Note: Aspartate aminotransferase activity (AST), alanine aminotransferase activity (ALT), alkaline phosphatase activity (ALP), albumin (ALB), total protein (TP), glucose (GLU), total cholesterol (CHOL), creatine phosphokinase activity (CPK), total bilirubin (T-BIL), direct bilirubin (D-BIL), creatinine (CRE), triglycerides (TG), urea (Ure), sodium ions (Na+), potassium ions (K+), chlorideions (Cl-). Values are mean ± S.D. (n = 5 (4 weeks), 10 (26 weeks) or recovery (30 weeks)/sex/dose). * P < 0.05 & ** P < 0.01 compared with normal group.