Skip to main content

Table 1 Histone modifications and the associated chromatin conformation

From: Histone modifications and traditional Chinese medicinals

Histone/DNA modification

Enzymes

Position/abbreviation*

Conformation

Reference

cytosine methylation

DNA methyltransferase

DNMT

heterochromatic

[24]

histone acetylation

histone acetyltransferase

HAT

euchromatic

[2]

histone deacetylation

histone deacetylase

HDAC

heterochromatic

[2]

histone methylation

histone methyltransferase

H3K4

euchromatic

[25]

H3K36

euchromatic

H3K79

euchromatic

H3R17

euchromatic

H3K9

heterochromatic

H3K27

heterochromatic

H4K20

heterochromatic

histone demethylation

histone demethylase

H3K4i

heterochromatic

[26]

H3K36i

heterochromatic

H3R2i

heterochromatic

H4R3i

heterochromatic

H3K27i

euchromatic

histone phosphorylation

mitogen- and stress-activated protein kinase (MSK), I kappa B alpha kinase (IKK)

H3S10

euchromatic

[27]

histone de-phosphorylation

MAP kinase phosphatase (MKP)

H3S10i

heterochromatic

[28]

ATP-dependent chromatin remodeling

ATP-dependent chromatin remodeling complex

ATP

hetero- or euchromatic

[29]

  1. * K Lysine, R Arginine, S serine, H3K4 H3K4 methylation, H3K4i H3K4 demethylation, H3S10 H3S10 phosphorylation, H3S10i H3S10 dephosphorylation.