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Table 2 MIC values and cytotoxicity of the hexane crude extract and isolated compounds from M. undata

From: Antimicrobial activity and cytotoxicity of triterpenes isolated from leaves of Maytenus undata (Celastraceae)

 

Minimum inhibitory concentration (MIC, μg/ml)

Cytotoxicity

 

C. albicans

C. neoformans

E. coli

E. faecalis

S. aureus

P. aeruginosa

Vero cells (LC50)

HA titre value

       

(μg/ml)

 

Hexane extract

300±0.01

20±0.00

120±0.06

80±0.03

630±0.00

300±0.00

76±0.05

1.60

Compound 1 1

>250±0.00

>250±0.00

>250±0.00

>250±0.00

>250±0.00

>250±0.00

>200±0.00

**2

Compound 3

>250±0.00

>250±0.00

>250±0.00

130±0.04

>250±0.00

>250±0.01

>200±0.00

**2

Compound 5

63±0.02

47±0.01

32±0.02

32±0.05

>250±0.01

36±0.04

6.03±0.02

1.33

Compound 6

63±0.05

47±0.02

24±0.05

63±0.04

>250±0.00

32±0.02

2.98±0.01

0.67

Amphotericin B

0.16±0.00

0.16±0.00

      

Gentamicin

  

6.30±0.00

25±0.00

15±0.01

3.20±0.03

  

Berberine

      

12.35±0.00

 

Acetylsalicyclic acid

       

0.80

  1. 1friedelin (1), friedelan-3β-ol (2), taraxerol (3), 3-oxo-11α-methoxyolean-12-ene-30-oic acid (4), 3-oxo-11α-hydroxyolean-12-ene-30-oic acid (5), 3,11-dihydroxyolean-12-ene-30-oic acid (6).
  2. 2** Low haemagglutination (HA) titre value (compounds not toxic).