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Table 1 Expression changes of estrogen-responsive genes in MCF-7 cells treated with E2 and SWT

From: Transcriptional profiling of Chinese medicinal formula Si-Wu-Tang on breast cancer cells reveals phytoestrogenic activity

 

Fold change (treatment/control)

Affymetrix probe ID

Gene symbol

Description

E2

SH

SM

Up-regulated genes

237460_x_at

C14orf182

chromosome 14 open reading frame 182

13.77

6.29

1.18

228554_at

PGR

progesterone receptor

12.10

2.83

1.72

205862_at

GREB1

growth regulation by estrogen in breast cancer 1

10.87

5.08

2.37

206115_at

EGR3

early growth response 3

10.69

10.70

1.65

235004_at

RBM24

RNA binding motif protein 24

10.23

6.07

1.57

1557277_a_at

  

8.71

2.08

1.32

231120_x_at

PKIB

protein kinase (cAMP-dependent, catalytic) inhibitor beta

7.96

2.29

1.27

219525_at

SLC47A1

solute carrier family 47, member 1

7.93

2.22

1.40

205440_s_at

NPY1R

neuropeptide Y receptor Y1

7.08

2.81

1.84

44790_s_at

C13orf18

chromosome 13 open reading frame 18

7.08

2.97

2.59

213906_at

MYBL1

v-myb myeloblastosis viral oncogene homolog (avian)-like 1

6.78

1.26

1.29

220038_at

SGK3

serum/glucocorticoid regulated kinase family, member 3

6.63

1.79

1.51

222921_s_at

HEY2

hairy/enhancer-of-split related with YRPW motif 2

6.11

2.88

1.59

228241_at

AGR3

anterior gradient homolog 3 (Xenopus laevis)

6.08

2.55

1.84

204798_at

MYB

v-myb myeloblastosis viral oncogene homolog (avian)

5.96

2.37

1.92

227627_at

SGK3

serum/glucocorticoid regulated kinase family, member 3

5.83

1.69

1.54

208018_s_at

HCK

hemopoietic cell kinase

5.77

1.33

1.02

239777_at

C14orf182

chromosome 14 open reading frame 182

5.63

3.29

1.27

207886_s_at

CALCR

calcitonin receptor

5.38

2.59

1.86

232306_at

CDH26

cadherin 26

5.37

3.51

1.94

219743_at

HEY2

hairy/enhancer-of-split related with YRPW motif 2

5.30

1.83

1.37

208305_at

PGR

progesterone receptor

5.22

1.69

1.10

223551_at

PKIB

protein kinase (cAMP-dependent, catalytic) inhibitor beta

5.18

2.13

1.42

211421_s_at

RET

ret proto-oncogene

4.98

1.54

1.19

205326_at

RAMP3

receptor (G protein-coupled) activity modifying protein 3

4.67

2.35

1.87

244745_at

RERG

RAS-like, estrogen-regulated, growth inhibitor

4.61

1.43

1.51

237334_at

  

4.55

2.25

1.34

219702_at

PLAC1

placenta-specific 1

4.45

2.02

1.09

223201_s_at

TMEM164

transmembrane protein 164

4.44

1.68

1.23

219825_at

CYP26B1

cytochrome P450, family 26, subfamily B, polypeptide 1

4.42

1.26

1.19

224428_s_at

CDCA7

cell division cycle associated 7

4.39

1.11

1.45

209687_at

CXCL12

chemokine (C-X-C motif) ligand 12

4.31

1.77

1.29

242064_at

SDK2

sidekick homolog 2 (chicken)

4.25

1.48

0.99

219985_at

HS3ST3A1

heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

4.17

2.01

1.40

220486_x_at

TMEM164

transmembrane protein 164

4.09

1.64

1.22

201739_at

SGK1

serum/glucocorticoid regulated kinase 1

4.01

1.86

1.29

Down-regulated genes

242943_at

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

0.31

0.40

0.85

202948_at

IL1R1

interleukin 1 receptor, type I

0.32

0.40

0.78

229354_at

AHRR

aryl-hydrocarbon receptor repressor

0.33

0.83

0.80

230261_at

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

0.36

0.41

0.88

230836_at

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

0.37

0.35

0.88

228176_at

EDG3

endothelial differentiation, sphingolipid G-protein-coupled receptor, 3

0.38

0.67

0.95

205749_at

CYP1A1

cytochrome P450, family 1, subfamily A, polypeptide 1

0.38

1.76

0.97

213413_at

BG434174

STON1

0.39

0.27

0.63

  1. Gene expression of MCF-7 cells after 6 hours of treatment with 0.1 μM E2 or SWT (2.56, 0.256 or 0.0256 mg/ml) was analyzed by microarrays. Listed are selected genes that showed strongest up-regulation or down-regulations induced by E2 by applying the cutoff of fold change > 4 for up-regulated genes, fold change < 0.4 for down-regulated genes, and false discovery rate (FDR) < 0.01. Expression values are shown by fold changes between treatment and control, i.e., expression values relative to untreated control cells for E2, SH and SM. Fold changes in bold: FDR < 0.01.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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