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Table 3 Antidiarrhoeal activity of methanolic extract and fractions against castor oil-induced diarrhoea in rats

From: Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves

Group Dose (p.o.) No. of faeces in 4 h % inhibition of diarrhoea
Control 10 mL/kg, p.o. 22.5 ± 2.4 -
Loperamide 5 mg/kg, p.o. 9.5 ± 0.64* 57.78
Methanol 200 mg/kg, p.o. 15 ± 1.1* 33.33
400 mg/kg, p.o. 11.5 ± 0.09* 48.89
Ethyl acetate 200 mg/kg, p.o. 16.25 ± 1.38* 27.78
400 mg/kg, p.o. 11 ± 1.58* 51.11
Chloroform 200 mg/kg, p.o. 12 ± 1.29* 46.67
400 mg/kg, p.o. 11.25 ± 1.25* 50
Pet. ether 200 mg/kg, p.o. 15.5 ± 1.76* 31.11
  400 mg/kg, p.o. 13.75 ± 1.38* 38.89
  1. All values are expressed as mean ± SEM (n = 5); One-way analysis of variance (ANOVA) followed by Dunnett’s test. *P < 0.05, significant compared with the control samples.