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Table 5 Biochemical parameters at the end of study

From: RETRACTED ARTICLE: Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation “Qurs Tabasheer” in streptozotocin induced diabetic rats

S.No

Biochemical parameter

Normal control

Normal control + Qurs Tabasheer (200 mg/kg)

STZ-diabetic control

STZ-diabetic + Qurs Tabasheer (50 mg/kg)

STZ-diabetic + Qurs Tabasheer (100 mg/kg)

STZ-diabetic + Qurs Tabasheer (200 mg/kg)

STZ-diabetic + Glimepiride

1.

Fasting plasma glucose (mg/dL)

84.64 ± 3.634

78.64 ± 3.091

301.1 ± 5.345

194.2 ± 2.873*

133.8 ± 4.149*

88.52 ± 3.923***

101.1 ± 4.106

2

Fasting Plasma Insulin (μU/mL)

11.22 ± 0.2080

11.80 ± 0.3041

2.708 ± 0.2008

4.866 ± 0.3105

6.890 ± 0.1796*

9.674 ± 0.2214**

7.430 ± 0.2577

3.

Glycated Heamoglobin (A1c) (%)

1.594 ± 0.07737

1.600 ± 0.08961

3.444 ± 0.2352

1.718 ± 0.09896

1.874 ± 0.09239**

2.594 ± 0.2068***

1.878 ± 0.04271

4.

Total Cholesterol (mg/dl)

77.98 ± 4.946

85.60 ± 3.832

166.8 ± 3.133

152.6 ± 3.320

133.9 ± 3.762*

118.9 ± 5.337**

164.2 ± 5.620

5.

Triglycerides (mg/dl)

82.52 ± 5.211

77.54 ± 2.119

124.3 ± 3.229

118.9 ± 3.214

102.0 ± 1.360**

100.9 ± 3.313**

129.0 ± 3.316

6.

Hexokinase (μg/mg of tissue)

148.4 ± 1.606

142.5 ± 1.888

102.7 ± 1.732

107.3 ± 1.875

128.2 ± 3.487**

137.6 ± 3.432***

121.2 ± 1.511

7.

Glucose-6-Phosphatase (unit/mg of tissue)

10.27 ± 0.1574

10.22 ± 0.3006

15.79 ± 0.6483

14.45 ± 0.5288

12.99 ± 0.5063*

10.06 ± 0.2851***

15.08 ± 0.5064

8.

Fructose-1-6-biphosphatase (unit/mg of tissue)

30.30 ± 0.7938

30.04 ± 0.8185

51.19 ± 1.223

48.20 ± 1.272

38.19 ± 1.389*

34.67 ± 1.700**

41.02 ± 1.236

9.

Weight Variation (g)

201.8 ± 4.664

208.0 ± 4.713

134.5 ± 3.681

137.2 ± 3.374

144.9 ± 4.532*

150.8 ± 2.453**

155.3 ± 2.409

  1. The data are expressed in mean ± SEM) (n = number of animals in each group = 5). The comparisons were made by ANOVA followed by Dunnett’s test.
  2. ns-non-significant; STZ-streptozotocin.
  3. *P < 0.05 is considered as significant.
  4. **P < 0.01 is considered as very significant.
  5. ***P < 0.001 is considered as extremely significant.