S.No | Biochemical parameter | Normal control | Normal control + Qurs Tabasheer (200 mg/kg) | STZ-diabetic control | STZ-diabetic + Qurs Tabasheer (50 mg/kg) | STZ-diabetic + Qurs Tabasheer (100 mg/kg) | STZ-diabetic + Qurs Tabasheer (200 mg/kg) | STZ-diabetic + Glimepiride |
---|---|---|---|---|---|---|---|---|
1. | Fasting plasma glucose (mg/dL) | 84.64 ± 3.634 | 78.64 ± 3.091 | 301.1 ± 5.345 | 194.2 ± 2.873* | 133.8 ± 4.149* | 88.52 ± 3.923*** | 101.1 ± 4.106 |
2 | Fasting Plasma Insulin (μU/mL) | 11.22 ± 0.2080 | 11.80 ± 0.3041 | 2.708 ± 0.2008 | 4.866 ± 0.3105 | 6.890 ± 0.1796* | 9.674 ± 0.2214** | 7.430 ± 0.2577 |
3. | Glycated Heamoglobin (A1c) (%) | 1.594 ± 0.07737 | 1.600 ± 0.08961 | 3.444 ± 0.2352 | 1.718 ± 0.09896 | 1.874 ± 0.09239** | 2.594 ± 0.2068*** | 1.878 ± 0.04271 |
4. | Total Cholesterol (mg/dl) | 77.98 ± 4.946 | 85.60 ± 3.832 | 166.8 ± 3.133 | 152.6 ± 3.320 | 133.9 ± 3.762* | 118.9 ± 5.337** | 164.2 ± 5.620 |
5. | Triglycerides (mg/dl) | 82.52 ± 5.211 | 77.54 ± 2.119 | 124.3 ± 3.229 | 118.9 ± 3.214 | 102.0 ± 1.360** | 100.9 ± 3.313** | 129.0 ± 3.316 |
6. | Hexokinase (μg/mg of tissue) | 148.4 ± 1.606 | 142.5 ± 1.888 | 102.7 ± 1.732 | 107.3 ± 1.875 | 128.2 ± 3.487** | 137.6 ± 3.432*** | 121.2 ± 1.511 |
7. | Glucose-6-Phosphatase (unit/mg of tissue) | 10.27 ± 0.1574 | 10.22 ± 0.3006 | 15.79 ± 0.6483 | 14.45 ± 0.5288 | 12.99 ± 0.5063* | 10.06 ± 0.2851*** | 15.08 ± 0.5064 |
8. | Fructose-1-6-biphosphatase (unit/mg of tissue) | 30.30 ± 0.7938 | 30.04 ± 0.8185 | 51.19 ± 1.223 | 48.20 ± 1.272 | 38.19 ± 1.389* | 34.67 ± 1.700** | 41.02 ± 1.236 |
9. | Weight Variation (g) | 201.8 ± 4.664 | 208.0 ± 4.713 | 134.5 ± 3.681 | 137.2 ± 3.374 | 144.9 ± 4.532* | 150.8 ± 2.453** | 155.3 ± 2.409 |