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Table 5 Biochemical parameters at the end of study

From: Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation “Qurs Tabasheer” in streptozotocin induced diabetic rats

S.No Biochemical parameter Normal control Normal control + Qurs Tabasheer (200 mg/kg) STZ-diabetic control STZ-diabetic + Qurs Tabasheer (50 mg/kg) STZ-diabetic + Qurs Tabasheer (100 mg/kg) STZ-diabetic + Qurs Tabasheer (200 mg/kg) STZ-diabetic + Glimepiride
1. Fasting plasma glucose (mg/dL) 84.64 ± 3.634 78.64 ± 3.091 301.1 ± 5.345 194.2 ± 2.873* 133.8 ± 4.149* 88.52 ± 3.923*** 101.1 ± 4.106
2 Fasting Plasma Insulin (μU/mL) 11.22 ± 0.2080 11.80 ± 0.3041 2.708 ± 0.2008 4.866 ± 0.3105 6.890 ± 0.1796* 9.674 ± 0.2214** 7.430 ± 0.2577
3. Glycated Heamoglobin (A1c) (%) 1.594 ± 0.07737 1.600 ± 0.08961 3.444 ± 0.2352 1.718 ± 0.09896 1.874 ± 0.09239** 2.594 ± 0.2068*** 1.878 ± 0.04271
4. Total Cholesterol (mg/dl) 77.98 ± 4.946 85.60 ± 3.832 166.8 ± 3.133 152.6 ± 3.320 133.9 ± 3.762* 118.9 ± 5.337** 164.2 ± 5.620
5. Triglycerides (mg/dl) 82.52 ± 5.211 77.54 ± 2.119 124.3 ± 3.229 118.9 ± 3.214 102.0 ± 1.360** 100.9 ± 3.313** 129.0 ± 3.316
6. Hexokinase (μg/mg of tissue) 148.4 ± 1.606 142.5 ± 1.888 102.7 ± 1.732 107.3 ± 1.875 128.2 ± 3.487** 137.6 ± 3.432*** 121.2 ± 1.511
7. Glucose-6-Phosphatase (unit/mg of tissue) 10.27 ± 0.1574 10.22 ± 0.3006 15.79 ± 0.6483 14.45 ± 0.5288 12.99 ± 0.5063* 10.06 ± 0.2851*** 15.08 ± 0.5064
8. Fructose-1-6-biphosphatase (unit/mg of tissue) 30.30 ± 0.7938 30.04 ± 0.8185 51.19 ± 1.223 48.20 ± 1.272 38.19 ± 1.389* 34.67 ± 1.700** 41.02 ± 1.236
9. Weight Variation (g) 201.8 ± 4.664 208.0 ± 4.713 134.5 ± 3.681 137.2 ± 3.374 144.9 ± 4.532* 150.8 ± 2.453** 155.3 ± 2.409
  1. The data are expressed in mean ± SEM) (n = number of animals in each group = 5). The comparisons were made by ANOVA followed by Dunnett’s test.
  2. ns-non-significant; STZ-streptozotocin.
  3. *P < 0.05 is considered as significant.
  4. **P < 0.01 is considered as very significant.
  5. ***P < 0.001 is considered as extremely significant.