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P02.139. A comparative study of Chinese medicine and hormone therapy in the treatment of menopausal symptoms in perimenopausal and postmenopausal women

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BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201212 (Suppl 1) :P195

  • Published:


  • Public Health
  • Internal Medicine
  • Postmenopausal Woman
  • Estradiol
  • Clinical Symptom


To compare the therapeutic effect of a Chinese herbal medicine (CHM) named Kun Bao Wan, acupuncture and hormone therapy (HT) on menopause related symptoms of peri- and postmenopausal women.


Fifty seven Chinese women completed 2 months of treatment with either CHM (5 gr BID, n=22), acupuncture in conjunction with CHM (CHM 5 gr BID + 10 sessions of acupuncture, n=20) or hormone therapy (n=15). Clinical symptoms were assessed by Kupperman index. Levels of FSH, estradiol, and symptom intensity and count were measured before and after the treatment.


CHM, acupuncture+CHM and hormone therapy significantly decreased Kupperman score (p<0.001 in each group) and symptom count (p<0.05). The mean difference in Kupperman score between baseline and 2 months among the 3 groups was significantly varied (p=0.02) with better results for acupuncture+CHM compared with CHM alone. Acupuncture+CHM as well as hormone therapy significantly reduced the level of FSH (p<0.05), but CHM alone didn’t cause any significant decrease in the level of FSH (p>0.05). The mean difference in the level of FSH between baseline and 2 months among the 3 groups was significantly different (p=0.02) with significantly better results for HT compared to CHM. The 3 treatments did not make any significant increase in the level of E2 (p>0.05). In postmenopausal women, the effect of HT and acupuncture+CHM were significantly better than CHM alone (p<0.05) whilst in perimenopausal women they were the same.


The combination of Chinese herbal medicine and acupuncture proved as effective as hormone therapy in the treatment of menopausal symptoms, and it achieved better outcomes than herbal medicine alone, especially in postmenopausal women.

Authors’ Affiliations

Mashhad University of Medical Sciences, Mashad, Iran
Beijing University of Chinese Medicine, Beijing, China
Peking University People Hospital, Beijing, China
Islamic Azad University of Mashhad, Mashad, Iran
Department of Cardiology, Imam Reza Hospital, Amol, Iran


© Azizi et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.