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OA02.03. Nutrient biomarker patterns and rates of cognitive decline in dementia-free elders

Purpose

We previously identified three distinct nutrient biomarker patterns associated with both psychometric and neuroimaging indices of brain health in a cross-sectional analysis. The objective of this study was to examine the relationship between the nutrient biomarker patterns and cognitive decline over 2 years.

Methods

Thirty biological markers of diet were assayed in plasma from 104 dementia-free elders in the Oregon Brain Aging Study. Principal component analysis constructed distinct nutrient biomarker patterns. A linear regression model was used to assess the association between NBPs and rate of change in Clinical Dementia Rating - sum of box score over two years.

Results

Mean age was 87±10, 62% were female, and 10% were carrying the ApoEe4 allele. Two distinct nutrient biomarker patterns were associated with rates of cognitive decline: a vitamin pattern high in B, C, E and D (p=0.001) and a high trans fat pattern (p<0.001) associated with less and more decline over two years, respectively. These findings were independent of age, gender, education years, ApoEe4 carrier status and vascular risk factors.

Conclusion

A plasma nutrient profile high in certain vitamins and low in trans-fat may be prudent for maintaining cognitive function in older populations.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bowman, G., Quinn, J., Kaye, J. et al. OA02.03. Nutrient biomarker patterns and rates of cognitive decline in dementia-free elders. BMC Complement Altern Med 12 (Suppl 1), O7 (2012). https://doi.org/10.1186/1472-6882-12-S1-O7

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  • DOI: https://doi.org/10.1186/1472-6882-12-S1-O7

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