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  • Oral presentation
  • Open Access

OA02.03. Nutrient biomarker patterns and rates of cognitive decline in dementia-free elders

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BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201212 (Suppl 1) :O7

  • Published:


  • Dementia
  • Cognitive Decline
  • Linear Regression Model
  • Carrier Status
  • Aging Study


We previously identified three distinct nutrient biomarker patterns associated with both psychometric and neuroimaging indices of brain health in a cross-sectional analysis. The objective of this study was to examine the relationship between the nutrient biomarker patterns and cognitive decline over 2 years.


Thirty biological markers of diet were assayed in plasma from 104 dementia-free elders in the Oregon Brain Aging Study. Principal component analysis constructed distinct nutrient biomarker patterns. A linear regression model was used to assess the association between NBPs and rate of change in Clinical Dementia Rating - sum of box score over two years.


Mean age was 87±10, 62% were female, and 10% were carrying the ApoEe4 allele. Two distinct nutrient biomarker patterns were associated with rates of cognitive decline: a vitamin pattern high in B, C, E and D (p=0.001) and a high trans fat pattern (p<0.001) associated with less and more decline over two years, respectively. These findings were independent of age, gender, education years, ApoEe4 carrier status and vascular risk factors.


A plasma nutrient profile high in certain vitamins and low in trans-fat may be prudent for maintaining cognitive function in older populations.

Authors’ Affiliations

Oregon Health & Science University, Portland, USA