Table 5 Effect of SAME on absolute liver weight, relative liver weight, and % DNA fragmentation and AgNORs in rat liver

Control

35.00 ± 0.87++

7.0 ± 0.23++

0.07 ± 0.002++

2.0 ± 0.33++

5.33 ± 2.46++

3 ml/kg CCl₄

24.52 ± 0.92**

8.6 ± .89**

0.86 ± .0016**

6.4 ± .29**

22.50 ± 3.68**

100 mg/kg SAME + CCl₄

30.08 ± 0.81**++

7.4 ± 0.10*++

0.074 ± 0.001*++

3.5 ± 0.18**++

6.67 ± 2.08++

200 mg/kg SAME + CCl₄

35.64 ± 0.73++

7.04 ± 0.23++

0.070 ± 0.0023++

2.14 ± 0.23++

5.67 ± 3.12++

100 mg/kg Silymarin + CCl₄

36.82 ± 0.69++

6.83 ± 0.07++

0.068 ± 0.007++

1.9 ± 0.17**++

4.67 ± 2.23++

200 mg/kg SAME alone

35.72 ± 0.70++

6.8 ± 0.12++

0.068 ± 0.011++

1.96 ± 0.12++

5.50 ± 3.2++