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Table 1 Mutagenic activity (mean of the number of revertants/plate ± SD) of the bacterial strains TA98, TA100, TA97a and TA102 exposed to Dipteryx alata Vogel hydroalcoholic extract, at various concentrations, with (+S9) or without (-S9) metabolic activation

From: In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract

Treatment (mg/plate) TA98 TA100 TA97a TA102
  - S9 + S9 - S9 + S9 - S9 + S9 - S9 + S9
0* 25 ± 1.0 23 ± 2.5 155 ± 5.9 207 ± 19.0 197 ± 3.5 188 ± 121 275 ± 14.5 200 ± 9.0
3.6 - - - 201 ± 23.5 (0.9) 227 ± 10.8* (1.2) 213 ± 9.9 (1.1) 229 ± 31.8 (0.9) 277 ± 26.9 (1.4)
4.7 25 ± 1.0 (1.0) 23 ± 2.9 (1.0) 135 ± 4.0 (0.9) - - - - -
7.1 - - - 238 ± 16.5 (1.1) 203 ± 13.5 (1.0) 199 ± 3.5 (1.1) 218 ± 12.1 (0.9) 299 ± 4.6* (1.5)
9.4 40 ± 8.7* (1.6) 24 ± 2.7 (1.0) 149 ± 10.0 (0.9) - - - - -
14.1 - - - 220 ± 14.8 (1.1) 201 ± 18.9(1.0) 198 ± 12.0 (1.1) 223 ± 3.5 (0.9) 303 ± 5.5* (1.5)
18.8 31 ± 4.4 (1.2) 23 ± 2.0 (1.0) 193 ± 11.7 (1.3) - - - - -
21.2 - - - 190 ± 16.9 (0.9) 158 ± 31.2 (0.8) 188 ± 7.4 (1.0) 204 ± 15.0 (0.7) 291 ± 1.5 (1.4)
28.2 38 ± 2.9* (1.5) 23 ± 2.1 (1.0) 208 ± 14.0 (1.3) - - - - -
37.6 32 ± 6.7 (1.3) 23 ± 2.1 (1.0) 226 ± 40.0* (1.5) - - - - -
Control + 2757 ± 208.5d 879 ± 46.1a 923 ± 134.6b 1357 ± 10.6 a 1470 ± 85.9 d 1210 ± 14.5 a 1733 ± 149.7 c 1280 ± 15.3 a
  1. -: not assayed; 0*: negative control (DMSO, 100 μL/plate); Control +: positive control; a 2-Anthramine (1.25 μg/plate); b Sodium azide (1.25 μg/plate); c Mitomycin (0.5 μg/plate); d4-nitro-o-phenylenediamine (10.0 μg/plate); * p < 0.05 (ANOVA). The values in brackets represent the mutagenic index.