Table 4 Serum biochemical values following 13 weeks of daily oral administration of NS in male and female rats
Serum Chemistry Values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Dose (mg/kg) | Sex | AST | ALT | ALP | BUN | CRE | GLU | CHO | PRO | CPK | ALB |
(IU/L) | (IU/L) | (IU/L) | (mg/dl) | (mg/dl) | (mg/dl) | (mg/dl) | (g/dl) | (IU/L) | (g/dl) | ||
0 | M | 83.3 ± 15.0 | 40.4 ± 9.0 | 83.2 ± 14.2 | 16.2 ± 1.6 | 0.5 ± 0.1 | 132.2 ± 14.1 | 113.1 ± 15.7 | 6.2 ± 0.2 | 211.3 ± 129 | 3.0 ± 0.1 |
F | 85.7 ± 12.5 | 33.6 ± 7.8 | 74.3 ± 18.6 | 15.1 ± 1.3 | 0.6 ± 0.0 | 108.2 ± 6.9 | 95.2 ± 18.5 | 6.0 ± 0.4 | 186.8 ± 72.0 | 3.1 ± 0.2 | |
500 | M | 80.0 ± 12.1 | 42.2 ± 5.4 | 90.6 ± 23.6 | 16.2 ± 3.0 | 0.5 ± 0.1 | 123.6 ± 12.1 | 108.0 ± 18.2 | 6.1 ± 0.1 | 173.1 ± 86.8 | 2.95 ± .01 |
F | 92.9 ± 13.1 | 33.4 ± 3.9 | 69.8 ± 12.4 | 16.4 ± 3.0 | 0.6 ± 0.1 | 114.4 ± 7.5 | 90.1 ± 12.8 | 6.1 ± 0.2 | 173.6 ± 74.8 | 3.1 ± 0.1 | |
1000 | M | 84.1 ± 17.1 | 40.9 ± 6.1 | 92.1 ± 18.8 | 15.4 ± 1.6 | 0.5 ± 0.1 | 131.1 ± 17.0 | 103.1 ± 21.7 | 6.1 ± 0.2 | 157.8 ± 97.1 | 3.0 ± 0.1 |
F | 96.0 ± 21.0 | 35.0 ± 7.0 | 69.3 ± 16.9 | 16.0 ± 2.3 | 0.6 ± 0.1 | 107.5 ± 9.6 | 96.9 ± 20.3 | 6.2 ± 0.3 | 173.4 ± 87.4 | 3.2 ± 0.2 | |
2000 | M | 83.1 ± 19.3 | 44.2 ± 12.4 | 84.0 ± 13.7 | 16.9 ± 3.6 | 0.5 ± 0.0 | 133.6 ± 12.6 | 111.4 ± 27.3 | 6.3 ± 0.1 | 122.3 ± 65.2 | 3.0 ± 0.1 |
F | 98.8 ± 22.5 | 35.8 ± 4.6 | 77.6 ± 14.2 | 16.4 ± 2.0 | 0.6 ± 0.1 | 112.8 ± 10.3 | 90.0 ± 20.1 | 6.0 ± 0.4 | 141.0 ± 61.2 | 3.1 ± 0.1 | |