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Table 2 Relative cytotoxicity of ascorbic acid and hydrogen peroxide (H 2 O 2 ) on cancer cells

From: Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

Cell line

EC50ascorbic acid (mmol/L)

EC50H2O2(μmol/L)

BT-20

94.9

241,2

SKOV-3

79.4

172,0

23132/87

89.0

165,5

U-87

2.8

96.6

U-251

2.6

77.1

  1. Five cancer cell lines, characterized by their different susceptibility to the ascorbic acid-mediated cytotoxic effect based on the generation of hydrogen peroxide, were analysed for their susceptibility to hydrogen peroxide-mediated cytotoxicity.