Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant

Table 5 Effect of intraperitoneal administration of VBME at 100, 200 and 300mg/kg in carrageenan and histamine induced paw edema test

Treatment	Dose mg/kg	NPS	0h	1h	2h	3h	4h	5h
Saline	10ml	0.0960 ± 0.22	0.2160 ± 0.24	0.2180 ± 0.12	0.2195 ± 0.20	0.2040 ± 0.14	0.2040 ± 0.18	0.2060 ± 0.17
Diclofenac	10mg	0.0900 ± 0.20	0.2180 ± 0.23	0.1487* ± 0.02	0.0980** ± 0.08	0.0499** ± 0.03	0.0620** ± 0.02	0.0821** ± 0.06
Anti-inflammatory effect against carrageenan induced paw edema
VBME	100	0.0920 ± 0.24	0.2140 ± 0.20	0.2020 ± 0.09	0.1902 ± 0.16	0.1499* ± 0.35	0.1580 ± 0.14	0.1680 ± 0.24
	200	0.0980 ± 0.18	0.2060 ± 0.19	0.1723* ± 0.27	0.1500* ± 0.29	0.0998** ± 0.31	0.1145* ± 0.40	0.1240* ± 0.20
	300	0.0980 ± 0.20	0.2190 ± 0.22	0.1680* ± 0.27	0.1247* ± 0.32	0.0799** ± 0.19	0.0940** ± 0.37	0.1009** ± 0.17
Anti-inflammatory effect against histamine induced paw edema
VBME	200	0.0970 ± 0.12	0.2070 ± 0.42	0.1628* ± 0.43	0.1520* ± 0.21	0.0999** ± 0.22	0.1091* ± 0.31	0.1109* ± 0.19
	300	0.0967 ± 0.32	0.2092 ± 0.53	0.1185* ± 0.87	0.1155* ± 0.24	0.0810** ± 0.71	0.0905** ± 0.33	0.1013** ± 0.18

NPS (Normal Paw size). Values are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01.

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