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Table 5 Effect of intraperitoneal administration of VBME at 100, 200 and 300mg/kg in carrageenan and histamine induced paw edema test

From: Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant

Treatment Dose mg/kg NPS 0h 1h 2h 3h 4h 5h
Saline 10ml 0.0960 ± 0.22 0.2160 ± 0.24 0.2180 ± 0.12 0.2195 ± 0.20 0.2040 ± 0.14 0.2040 ± 0.18 0.2060 ± 0.17
Diclofenac 10mg 0.0900 ± 0.20 0.2180 ± 0.23 0.1487* ± 0.02 0.0980** ± 0.08 0.0499** ± 0.03 0.0620** ± 0.02 0.0821** ± 0.06
Anti-inflammatory effect against carrageenan induced paw edema
VBME 100 0.0920 ± 0.24 0.2140 ± 0.20 0.2020 ± 0.09 0.1902 ± 0.16 0.1499* ± 0.35 0.1580 ± 0.14 0.1680 ± 0.24
200 0.0980 ± 0.18 0.2060 ± 0.19 0.1723* ± 0.27 0.1500* ± 0.29 0.0998** ± 0.31 0.1145* ± 0.40 0.1240* ± 0.20
300 0.0980 ± 0.20 0.2190 ± 0.22 0.1680* ± 0.27 0.1247* ± 0.32 0.0799** ± 0.19 0.0940** ± 0.37 0.1009** ± 0.17
Anti-inflammatory effect against histamine induced paw edema
VBME 200 0.0970 ± 0.12 0.2070 ± 0.42 0.1628* ± 0.43 0.1520* ± 0.21 0.0999** ± 0.22 0.1091* ± 0.31 0.1109* ± 0.19
  300 0.0967 ± 0.32 0.2092 ± 0.53 0.1185* ± 0.87 0.1155* ± 0.24 0.0810** ± 0.71 0.0905** ± 0.33 0.1013** ± 0.18
  1. NPS (Normal Paw size). Values are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01.