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Table 3 Effect of VBME 100, 200 and 300mg/kg in hot plat test

From: Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant

Group Treatment/kg 0min 30min 60min 90min 120min
Saline 10ml 9.20 ± 0.02 9.22 ± 0.08 9.16 ± 0.09 9.20 ± 0.03 9.12 ± 0.11
VBME 100mg 9.21 ±0.23 11.92 ± 0.44 13.20* ± 0.87 12.78* ± 0.46 12.58* ± 0.34
200mg 9.23 ±0.65 12.85 ± 0.87 14.51** ± 0.54 14.30** ± 0.84 14.09** ± 0.91
300mg 9.24 ±0.76 19.76* ± 0.22 23.74** ± 0.12 23.10** ± 0.12 22.98** ± 0.69
TramadolR 30mg 9.20 ±0.02 25.34** ± 0.04 25.88*** ± 0.06 25.80*** ± 0.07 25.77*** ± 0.00
Analgesic effect of TramadolR and VBME antagonized by Naloxone
VBME 300mg 9.21 ±0.45 10.78** ± 0.56 10.80** ± 0.39 10.91** ± 0.89 10.98** ± 0.78
200mg 9.22 ±0.76 10.80** ± 0.87 10.75** ± 0.92 10.82** ± 0.72 10.86** ± 0.92
TramadolR 30mg 9.23 ±0.02 10.22** ± 0.05 10.02*** ± 0.09 10.24*** ± 0.03 10.05*** ± 0.00
  1. Values are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01, ***P < 0.001.