Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant

Table 3 Effect of VBME 100, 200 and 300mg/kg in hot plat test

Group	Treatment/kg	0min	30min	60min	90min	120min
Saline	10ml	9.20 ± 0.02	9.22 ± 0.08	9.16 ± 0.09	9.20 ± 0.03	9.12 ± 0.11
VBME	100mg	9.21 ±0.23	11.92 ± 0.44	13.20* ± 0.87	12.78* ± 0.46	12.58* ± 0.34
	200mg	9.23 ±0.65	12.85 ± 0.87	14.51** ± 0.54	14.30** ± 0.84	14.09** ± 0.91
	300mg	9.24 ±0.76	19.76* ± 0.22	23.74** ± 0.12	23.10** ± 0.12	22.98** ± 0.69
Tramadol^R	30mg	9.20 ±0.02	25.34** ± 0.04	25.88*** ± 0.06	25.80*** ± 0.07	25.77*** ± 0.00
Analgesic effect of Tramadol^R and VBME antagonized by Naloxone
VBME	300mg	9.21 ±0.45	10.78** ± 0.56	10.80** ± 0.39	10.91** ± 0.89	10.98** ± 0.78
VBME	200mg	9.22 ±0.76	10.80** ± 0.87	10.75** ± 0.92	10.82** ± 0.72	10.86** ± 0.92
Tramadol^R	30mg	9.23 ±0.02	10.22** ± 0.05	10.02*** ± 0.09	10.24*** ± 0.03	10.05*** ± 0.00

Values are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01, ***P < 0.001.

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