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Table 1 Effects of Rg1 on blood pressure

From: The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats

 

WKY

SHR

SHR-Rg1(5)

SHR-Rg1(10)

SHR-Rg1(20)

SBP(mmHg)

133.7 ± 2.2

184.5 ± 3.4###

186.0 ± 2.4###

183.5 ± 3.3###

183.0 ± 4.2###

DBP(mmHg)

97.5 ± 2.0

139.0 ± 3.0###

138.0 ± 2.4###

139.1 ± 2.8###

133.8 ± 3.9###

HR (bpm)

360.6 ± 14.0

393.6 ± 12.5#

366.7 ± 13.7

412.6 ± 8.9

433.5 ± 9.3*

MAP(mmHg)

111.5 ± 6.3

170.1 ± 16.7###

181.6 ± 14.0###

175.4 ± 37.4###

193.7 ± 10.4###

EDP(mmHg)

6.1 ± 1.7

7.5 ± 3.0

3.1 ± 1.0

4.8 ± 3.9

5.5 ± 1.8

LVSP(mmHg)

120.9 ± 7.1

207.1 ± 17.9###

213.7 ± 21.1###

224.3 ± 35.4###

217.5 ± 16.8###

+dP/dtmax (mm HgS-1)

8661.1 ± 717.7

11735.7 ± 635.8##

13063.6 ± 470.8###

12651.9 ± 803.0##

12636.7 ± 514.7###

-dP/dtmax (mm HgS-1)

−7514.6 ± 626.0

−11272.1 ± 872.8##

−12410.0 ± 595.7###

−11330.2 ± 722.8###

−11464.1 ± 534.8###

HW/BW(mg/g)

2.9 ± 0.2

3.9 ± 0.05#

3.8 ± 0.08#

3.8 ± 0.07#

3.6 ± 0.06# **

  1. All the values are expressed as mean ± S.E. Systolic pressure (SBP), diastolic pressure (DBP), heart rate (HR), mean arterial pressure (MAP), maximum rate of pressure development for relaxation (−dP/dtmax), maximum rate of pressure development for contraction (+dP/dtmax), left ventricular systolic pressure (LVSP) were demonstrated. Heart weight divided by body weight (HW/BW) is also calculated. MAP, EDP, LVSP, +dp/dtmax, -dp/dtmax were acquired using Millar catheter and recorded by PowerLab 8/30 instrument (ADInstruments, Australia). Heart rate, SBP and DBP were acquired by tail-cuff apparatus. Mean values of data from different treatment groups were compared using one-way ANOVA. After confirming the equal variances, unpaired Student’s t-test was used to compare difference between means of two groups using SigmaPlot software. # P < 0.05, ### P < 0.001 versus WKY; **P < 0.01, ***P < 0.001 versus SHR. n = 10 for each group.