Figure 2

Changes in hemoglobin A1c during ANC compared to usual care. P values for within cohort change were computed using maximum likelihood estimates of mean HbA1c (random intercept, mixed effects model) and correspond to within cohort 2-sided t-tests; between cohort comparisons of mean change from baseline are from the random slope and intercept mixed models (maximum likelihood, similar to unpaired t-test of mean change over the observation period), adjusted for age, gender, baseline HbA1c and use of sulfonylureas and/or metformin at baseline. ANC = Adjunctive Naturopathic Care, UC = Usual Care.