Figure 3

Effect of prepubertal oral administration of AESb on the timing of Puberty onset. Shown on the left are mean day of vaginal opening in control and prepubertal AESb-treated animals. Shown on the right are percentages of animal showing vaginal opening as a function of age in the control and AESb-treated animals. *Values significantly different at p < 0.05 from those of the control group (Kruskal-Wallis followed by Mann-Whitney tests for histograms and Khi Square followed by Fisher Exact tests for lines); each data represents the mean ± SEM of 13 animals.