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Table 2 Effects of Bersama engleriana on body weight, relative weights of liver and pancreas and, lipid profile on nicotinamide/streptozotocin-induced diabetic rats

From: Hypoglycemic and hypolipidemic effects of Bersama engleriana leaves in nicotinamide/streptozotocin-induced type 2 diabetic rats

Groups

Body weight(g)

Relative organ weight (mg/g)

Lipid profile(mg/dl)

 

Initial

Final

% variation

Liver

Pancreas

TC

LDL-C

HDL-C

TG

Control

210.06 ± 11.25

251.00 ± 10.57

19.48

33.86 ± 01.07

4.11 ± 0.50

98.06 ± 05.54

45.37 ± 03.93

36.15 ± 02.50

82.70 ± 05.81

Untreated diabetic

210.53 ± 12.36

203.00 ± 04.52

-3.57

11.23 ± 0.70***

1.37 ± 0.08***

153.53 ± 17.82*

118.8 3± 12.82*

12.44 ± 03.65*

96.39 ± 15.83

Diabetic + Glibenclamide (0.25 mg/kg)

217.88 ± 22.06

250.50 ± 10.57

14.97

13.46 ± 01.31***

0.96 ± 0.09***

134.77 ± 07.58*

88.09 ± 11.14*#

20.42 ± 02.84*

70.60 ± 07.87#

Diabetic + Aqueous extract (300 mg/kg)

250.85 ± 12.06

230.00 ± 06.35

-8.31

14.56 ± 0.69***

1.23 ± 0.15***

127.97 ± 02.07

89.27 ± 07.67*#

17.60 ± 02.05*

64.05 ± 09.61*#

Diabetic + Aqueous extract (600 mg/kg)

254.85 ± 15.50

237.33 ± 06.33

-6.87

15.70 ± 01.59***

1.60 ± 0.21***

130.62 ± 06.57*

76.12 ± 02.35*##

12.10 ± 01.51*

79.51 ± 11.64#

Diabetic + Methanolic extract (300 mg/kg)

199.41 ± 06.56

224.00 ± 11.69

12.33

15.69 ± 0.55***

2.42 ± 0.21***##

123.32 ± 12.46

89.48 ± 12.69*#

29.96 ± 07.28#

59.56 ± 11.39***#

Diabetic + Methanolic extract (600 mg/kg)

187.98 ± 09.24

223.67 ± 07.57

19.05

19.23 ±01.19***###

2.41 ± 0.16***##

100.75 ± 14.74#

59.19 ± 08.39###

32.97 ± 04.37#

56.01 ± 09.70***##

  1. Values are means ± SEM; number of animals per group = 6.
  2. *: p<0.05; *** p <0.001: significantly different compared to control.
  3. #: p <0.05; ##: p <0.01; ###: p<0.001 significantly different compared to untreated diabetic.