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Table 4 Effects of GE on the expression of inflammatory markers in adipose tissue

From: Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet

Genes investigated

ND240

HFD60

HFD120

HFD240

HFDMET

IL-6

−1.17±0.67

−1.38±0.41c

−1.11±0.20d

−3.27±0.92b

−1.35±0.03c

CRP

−2.10±0.60

0.10±0.78a

−4.00±0.21b

−3.40±0.87b

−2.30±0.12c

MCP-1

−1.63±0.45

1.09±0.14b

−2.33±0.24c

−1.33±0.69d

−1.20±1.10d

SAA-2

−1.55±0.66

−5.53±0.47b

−5.39±0.54b

−5.67±0.95b

−3.82±0.77c

NF-κB

−1.11±0.37

−2.30±0.29b

−2.90±0.92c

−2.30±0.30b

−2.45±1.13b

TNF-α

−3.46±0.09

1.16±0.21b

−4.50±0.43c

−4.11±0.37c

−1.79±1.06d

  1. Results are expressed as –fold variation over the appropriate control groups; ND240 indicate fold increase over ND, normal diet control group and HFD60, HFD120, HFD240 and HFDMET indicate fold increase over HFD, high-fat diet control group. Fold variations less than one were expressed as negative numbers (e.g., a –fold variation of 0.50 is expressed as −2.00). Values expressed are means ± S.D of triplicate measurements. Statistical significance was calculated based on the mean ΔCT values by DMRT for only mice fed with high-fat diet with or without GE. For same gene with different treatment groups, means in the different rows with different alphabets (a-d) were significantly different (p<0.05).