Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial

Table 2 Mean flow-mediated dilation, brachial artery diameter, velocity-time integral, and blood pressure by dose (N = 21)

	Placebo	1000 mg	1500 mg	2500 mg	p-value ¹
FMD
Δ BAD, mm	0.18 (0.14)	0.16 (0.12)	0.14 (0.13)	0.17 (0.12)	0.54
FMD, %	5.3 (4.3)	5.0 (4.1)	4.3 (4.0)	4.9 (4.1)	0.59
BAD, mm
Resting	3.5 (0.7)	3.5 (0.8)	3.6 (0.8)	3.5 (0.8)	0.74
Hyperemia	3.7 (0.7)	3.6 (0.8)	3.7 (0.8)	3.7 (0.8)	-
VTI, cm	85.7 (20.8)	91.3 (19.5)	82.0 (21.4)	83.9 (18.0)	0.31
Blood Pressure, mm Hg
Systolic	129.4 (8.1)	130.7 (10.7)	131.1 (13.6)	132.0 (10.0)	0.33
Diastolic	82.8 (7.3)	81.8 (7.8)	83.0 (9.1)	82.3 (7.7)	0.72

¹ p-value for modified linear contrast assessing dose-response from mixed effects linear model controlling for period and baseline response. Models for FMD also controlled for resting BAD.
All values expressed as mean (SD).
FMD - flow mediated dilation, BAD - brachial artery diameter, VTI - velocity-time integral

ISSN: 2662-7671