Treatment | Dose (mg/kg body wt.) | LPO (nmol/mg protein) | MPO (μmol/min/mg tissue) |
---|
Baseline (intact) | - | 2.85 ± 0.17 | 2.80 ± 0.20 |
Ulcer control | Vehicle | 8.34 ± 0.13a
| 9.20 ± 0.26a
|
CS-extract | 500 | 6.68 ± 0.11b
| 6.13 ± 0.27b
|
“ | 750 | 5.30 ± 0.15b, c
| 4.49 ± 0.12b, f
|
“ | 1000 | 3.13 ± 0.17b, d
| 3.27 ± 0.10b, d
|
Ranitidine | 50 | 5.09 ± 0.06b, e
| 4.22 ± 0.08b, e
|
-
a p< 0.001 compared with baseline; b p< 0.001 compared with ulcer control; c p< 0.001 compared with CS-500; d p< 0.001 compared with CS-750; e p< 0.001 compared with CS-1000; f p< 0.05 compared with CS-500; Values are Mean ± SEM of 6 animals. Statistical significance was determined by one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc t test.