Skip to main content

Table 2 Effect of C. sieberiana (CS) root bark extract on lipid peroxidation indices in ethanol-induced gastric ulcer rats

From: Anti-ulcerogenic activity of the root bark extract of the African laburnum “Cassia sieberiana” and its effect on the anti-oxidant defence system in rats

Treatment

Dose (mg/kg body wt.)

LPO (nmol/mg protein)

MPO (μmol/min/mg tissue)

Baseline (intact)

-

2.85 ± 0.17

2.80 ± 0.20

Ulcer control

Vehicle

8.34 ± 0.13a

9.20 ± 0.26a

CS-extract

500

6.68 ± 0.11b

6.13 ± 0.27b

750

5.30 ± 0.15b, c

4.49 ± 0.12b, f

1000

3.13 ± 0.17b, d

3.27 ± 0.10b, d

Ranitidine

50

5.09 ± 0.06b, e

4.22 ± 0.08b, e

  1. a p< 0.001 compared with baseline; b p< 0.001 compared with ulcer control; c p< 0.001 compared with CS-500; d p< 0.001 compared with CS-750; e p< 0.001 compared with CS-1000; f p< 0.05 compared with CS-500; Values are Mean ± SEM of 6 animals. Statistical significance was determined by one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc t test.