Safety and efficacy assessment of standardized herbal formula PM012

Sohn, Sung-Hwa; Kim, Soo-Jeong; Kim, Yong; Shim, Insop; Bae, Hyunsu

doi:10.1186/1472-6882-12-24

BMC Complementary Medicine and Therapies

Table 5 Absolute & relative organ weights in rats orally treated with PM012

From: Safety and efficacy assessment of standardized herbal formula PM012

		Dose (mg/kg)
Parameter	Sex	0			500		1000		2000
		4 Weeks	26 Weeks	Recovery	4 Weeks	26 Weeks	4 Weeks	26 Weeks	4 Weeks	26 Weeks	Recovery
Body weight^a)	Male	326.79 ± 18.46	484.71 ± 33.01	502.94 ± 17.59	321.28 ± 20.83	504.38 ± 45.11	330.67 ± 23.75	474.08 ± 46.03	324.80 ± 15.32	468.68 ± 35.08	507.84 ± 32.08
	Female	194.35 ± 7.86	268.94 ± 12.88	277.90 ± 26.72	195.07 ± 9.64	270.36 ± 13.17	196.26 ± 12.33	272.81 ± 19.48	195.04 ± 14.05	264.92 ± 17.98	279.89 ± 6.03
Adrenal grand (Lt.)	Male	0.0266 ± 0.0032	0.0258 ± 0.0025	0.0276 ± 0.0037	0.0260 ± 0.0033	0.0254 ± 0.0031	0.0265 ± 0.0025	0.0245 ± 0.0022	0.0290 ± 0.0011	0.0243 ± 0.0031	0.0271 ± 0.0037
	Female	0.0312 ± 0.0025	0.0311 ± 0.0038	0.0309 ± 0.0054	0.0309 ± 0.0023	0.0325 ± 0.0039	0.0333 ± 0.0025	0.0313 ± 0.0056	0.0314 ± 0.0038	0.0310 ± 0.0050	0.0326 ± 0.0053
% to body weight	Male	0.0082 ± 0.0014	0.0054 ± 0.0007	0.0055 ± 0.0007	0.0081 ± 0.0009	0.0050 ± 0.0005	0.0080 ± 0.0005	0.0052 ± 0.0006	0.0089 ± 0.0007	0.0052 ± 0.0006	0.0053 ± 0.0005
	Female	0.0161 ± 0.0016	0.0115 ± 0.0013	0.0112 ± 0.0022	0.0158 ± 0.0008	0.0120 ± 0.0013	0.0170 ± 0.0010	0.0115 ± 0.0019	0.0162 ± 0.0023	0.0117 ± 0.0020	0.0117 ± 0.0019
Adrenal grand (Rt.)	Male	0.0274 ± 0.0015	0.0247 ± 0.0027	0.0289 ± 0.0025	0.0255 ± 0.0015	0.0252 ± 0.0030	0.0246 ± 0.0046	0.0224 ± 0.0034	0.0264 ± 0.0026	0.0246 ± 0.0026	0.0278 ± 0.0054
	Female	0.0305 ± 0.0023	0.0295 ± 0.0030	0.0296 ± 0.0059	0.0308 ± 0.0045	0.0306 ± 0.0033	0.0305 ± 0.0019	0.0301 ± 0.0052	0.0313 ± 0.0041	00287 ± 0.0042	0.0314 ± 0.0048
% to body weight	Male	0.0084 ± 0.0008	0.0051 ± 0.0006	0.0057 ± 0.0005	0.0080 ± 0.0003	0.0050 ± 0.0003	0.0074 ± 0.0012	0.0048 ± 0.0009	0.0081 ± 0.0009	0.0053 ± 0.0006	0.0055 ± 0.0009
	Female	0.0157 ± 0.0013	0.0110 ± 0.0013	0.0108 ± 0.0026	0.0158 ± 0.0020	0.0113 ± 0.0010	0.0156 ± 0.0017	0.0110 ± 0.0019	0.0160 ± 0.0019	0.0109 ± 0.0018	0.0112 ± 0.0018
Pituitary grand	Male	ND^b)	0.0128 ± 0.0010	0.0135 ± 0.0017	ND^b)	0.0126 ± 0.0011	ND^b)	0.0126 ± 0.0013	ND^b)	0.0124 ± 0.0009	0.0135 ± 0.0014
	Female	ND^b)	0.0151 ± 0.0017	0.0153 ± 0.0011	ND^b)	0.0150 ± 0.0022	ND^b)	0.0170 ± 0.0042	ND^b)	0.0143 ± 0.0021	0.0160 ± 0.0017
% to body weight	Male	ND^b)	0.0026 ± 0.0002	0.0027 ± 0.0004	ND^b)	0.0025 ± 0.0002	ND^b)	0.0027 ± 0.0002	ND^b)	0.0027 ± 0.0001	0.0027 ± 0.0002
	Female	ND^b)	0.0056 ± 0.0005	0.0056 ± 0.0007	ND^b)	0.0055 ± 0.0009	ND^b)	0.0062 ± 0.0015	ND^b)	0.0054 ± 0.0009	0.0057 ± 0.0005
Thymus	Male	0.4132 ± 0.0579	0.1887 ± 0.0403	0.1668 ± 0.0116	0.5040 ± 0.0841	0.2201 ± 0.0349	0.4522 ± 0.0657	0.2055 ± 0.0585	0.4942 ± 0.0904	0.1981 ± 0.0361	0.1520 ± 0.0308
	Female	0.2837 ± 0.0195	0.1380 ± 0.0191	0.1320 ± 0.0144	0.3389 ± 0.0336	0.1418 ± 0.0126	0.3124 ± 0.0420	0.1535 ± 0.0347	0.3372 ± 0.0316	0.1533 ± 0.0233	0.1748 ± 0.0180**
% to body weight	Male	0.1269 ± 0.0197	0.0388 ± 0.0074	0.0332 ± 0.0022	0.1583 ± 0.0338	0.0437 ± 0.0059	0.1378 ± 0.0261	0.0433 ± 0.0111	0.1515 ± 0.0229	0.0424 ± 0.0076	0.0302 ± 0.0073
	Female	0.1462 ± 0.0121	0.0515 ± 0.0083	0.0478 ± 0.0070	0.1739 ± 0.0168**	0.0527 ± 0.0063	0.1588 ± 0.0146	0.0563 ± 0.0126	0.1729 ± 0.0095**	0.0580 ± 0.0088	0.0624 ± 0.0057**
Prostate	Male	0.2664 ± 0.0587	0.5802 ± 0.1913	0.5616 ± 0.1757	0.3106 ± 0.1454	0.6464 ± 0.1822	0.3022 ± 0.1208	0.5570 ± 0.1379	0.2706 ± 0.0913	0.6609 ± 0.1472	0.5776 ± 0.0680
% to body weight		0.0811 ± 0.0150	0.1215 ± 0.0438	0.1109 ± 0.0312	0.0950 ± 0.0412	0.1276 ± 0.0318	0.0921 ± 0.0389	0.1181 ± 0.0294	0.0825 ± 0.0256	0.1408 ± 0.0278	0.1141 ± 0.0152
Testis (Lt.)	Male	1.8696 ± 0.0630	2.0628 ± 0.1010	2.2032 ± 0.0711	1.8118 ± 0.2120	2.1428 ± 0.1616	1.7334 ± 0.2977	1.9960 ± 0.1191	1.8244 ± 0.0591	2.1109 ± 0.1282	2.0692 ± 0.1961
% to body weight		0.5739 ± 0.0444	0.4272 ± 0.0342	0.4385 ± 0.0211	0.5628 ± 0.0395	0.4264 ± 0.0331	0.5235 ± 0.0758	0.4242 ± 0.0432	0.5628 ± 0.0349	0.4522 ± 0.0376	0.4075 ± 0.0315
Testis (Rt.)	Male	1.8672 ± 0.0834	2.0352 ± 0.1580	2.1622 ± 0.0698	1.8232 ± 0.2055	2.1153 ± 0.1467	1.7288 ± 0.2737	2.0206 ± 0.1294	1.8008 ± 0.0563	2.0990 ± 0.1063	2.0372 ± 0.1672
% to body weight		0.5734 ± 0.0512	0.4218 ± 0.0453	0.4304 ± 0.0209	0.5664 ± 0.0357	0.4215 ± 0.0376	0.5226 ± 0.0718	0.4302 ± 0.0524	0.5553 ± 0.0288	0.4500 ± 0.0388	0.4021 ± 0.0375
Epididymis (Lt.)	Male	ND^b)	0.7142 ± 0.0282	0.7672 ± 0.0424	ND^b)	0.7532 ± 0.0594	ND^b)	0.7185 ± 0.0632	ND^b)	0.7396 ± 0.0401	0.7240 ± 0.0396
% to body weight		ND^b)	0.1478 ± 0.0092	0.1529 ± 0.0126	ND^b)	0.1499 ± 0.0120	ND^b)	0.1526 ± 0.0181	ND^b)	0.1584 ± 0.0120	0.1429 ± 0.0097
Epididymis (Rt.)	Male	ND^b)	0.7352 ± 0.0372	0.7620 ± 0.0299	ND^b)	0.7572 ± 0.0604	ND^b)	0.7429 ± 0.0493	ND^b)	0.7501 ± 0.0461	0.7184 ± 0.0322
% to body weight		ND^b)	0.1523 ± 0.0131	0.1517 ± 0.0090	ND^b)	0.1507 ± 0.0121	ND^b)	0.1578 ± 0.0157	ND^b)	0.1606 ± 0.0127	0.1417 ± 0.0062
Ovary (Lt.)	Female	0.0443 ± 0.0089	0.0388 ± 0.0120	0.0302 ± 0.0085	0.0434 ± 0.0037	0.0397 ± 0.0093	0.0452 ± 0.0077	0.0354 ± 0.0066	0.0411 ± 0.0051	0.0403 ± 0.0132	0.0317 ± 00129
% to body weight		0.0227 ± 0.0040	0.0143 ± 0.0040	0.0108 ± 0.0023	0.0223 ± 0.0024	0.0146 ± 0.0031	0.0230 ± 0.0035	0.0131 ± 0.0033	0.0210 ± 0.0020	0.0151 ± 0.0044	0.0114 ± 0.0048
Ovary (Rt.)	Female	0.0453 ± 0.0047	0.0375 ± 0.0087	0.0305 ± 0.0134	0.0430 ± 0.0067	0.0413 ± 0.0102	0.0454 ± 0.0081	0.0346 ± 0.0079	0.0456 ± 0.0071	0.0360 ± 0.0105	0.0296 ± 0.0078
% to body weight		0.0233 ± 0.0023	0.0139 ± 0.0031	0.0107 ± 0.0035	0.0221 ± 0.0036	0.0153 ± 0.0037	0.0231 ± 0.0035	0.0127 ± 0.0031	0.0234 ± 0.0035	0.0135 ± 0.0034	0.0106 ± 0.0029
Uterus	Female	0.6020 ± 0.5041	0.7540 ± 0.2803	1.5136 ± 1.7081	0.7301 ± 0.3711	0.7690 ± 0.2454	0.4385 ± 0.1144	0.6901 ± 0.2825	0.4302 ± 0.1316	1.0180 ± 0.7969	0.7328 ± 0.1301
% to body weight		0.3134 ± 0.2721	0.2805 ± 0.1043	0.5421 ± 0.5875	0.3756 ± 0.1879	0.2866 ± 0.0986	0.2219 ± 0.0471	0.2506 ± 0.0902	0.2244 ± 0.0825	0.3884 ± 0.3038	0.2615 ± 0.0441
Spleen	Male	0.7080 ± 0.0403	0.8423 ± 0.1620	0.9244 ± 0.1689	0.7766 ± 0.0442	0.8627 ± 0.1149	0.8082 ± 0.1229	0.8115 ± 0.1162	0.6982 ± 0.1578	0.8396 ± 0.0962	0.9108 ± 0.2680
	Female	0.5174 ± 0.0475	0.6023 ± 0.0677	0.5912 ± 0.0969	0.5178 ± 0.0523	0.5904 ± 0.0496	0.5450 ± 0.0515	0.5846 ± 0.0497	0.5438 ± 0.0540	0.5765 ± 0.0545	0.6338 ± 0.0327
% to body weight	Male	0.2167 ± 0.0048	0.1730 ± 0.0254	0.1838 ± 0.0339	0.2427 ± 0.0232	0.1712 ± 0.0202	0.2436 ± 0.0258	0.1712 ± 0.0173	0.2138 ± 0.0418	0.1796 ± 0.0205	0.1781 ± 0.0461
	Female	0.2665 ± 0.0256	0.2239 ± 0.0219	0.2117 ± 0.0160	0.2655 ± 0.0242	0.2182 ± 0.0115	0.2778 ± 0.0218	0.2152 ± 0.0231	0.2786 ± 0.0136	0.2177 ± 0.0161	0.2264 ± 0.0087
Kidney (Lt.)	Male	1.0834 ± 0.0737	1.4412 ± 0.0916	1.5350 ± 0.1345	1.1088 ± 0.1901	1.4725 ± 0.2157	1.1310 ± 0.0947	1.3753 ± 0.1792	1.0716 ± 0.0701	1.4461 ± 0.3356	1.4692 ± 0.2390
	Female	0.6434 ± 0.0440	0.7791 ± 0.0439	0.8626 ± 0.0847	0.6320 ± 0.0439	0.7969 ± 0.0477	0.6650 ± 0.0495	0.8142 ± 0.0688	0.6674 ± 0.0675	0.8092 ± 0.0705	0.8742 ± 0.0311
% to body weight	Male	0.3318 ± 0.0193	0.2978 ± 0.0159	0.3050 ± 0.0219	0.3432 ± 0.0376	0.2910 ± 0.0249	0.3419 ± 0.0083	0.2899 ± 0.0205	0.3299 ± 0.0131	0.3073 ± 0.0569	0.2890 ± 0.0406
	Female	0.3312 ± 0.0210	0.2901 ± 0.0188	0.3113 ± 0.0296	0.3238 ± 0.0086	0.2949 ± 0.0128	0.3387 ± 0.0089	0.2988 ± 0.0206	0.3417 ± 0.0114	0.3057 ± 0.0212	0.3124 ± 0.0119
Kidney (Rt.)	Male	1.0920 ± 0.0966	1.4783 ± 0.0904	1.5424 ± 0.1388	1.0810 ± 0.1098	1.5046 ± 0.2471	1.1354 ± 0.0658	1.3637 ± 0.1638	1.0760 ± 0.0876	1.3921 ± 0.1399	1.4910 ± 0.2666
	Female	0.6700 ± 0.0245	0.7974 ± 0.0511	0.8416 ± 0.0896	0.6542 ± 0.0316	0.8195 ± 0.0634	0.6956 ± 0.0681	0.8177 ± 0.0871	0.6604 ± 0.0610	0.8213 ± 0.0652	0.8740 ± 0.0535
% to body weight	Male	0.3345 ± 0.0286	0.3055 ± 0.0175	0.3064 ± 0.0217	0.3361 ± 0.0184	0.2969 ± 0.0260	0.3437 ± 0.0108	0.2879 ± 0.0218	0.3310 ± 0.0159	0.2969 ± 0.0165	0.2931 ± 0.0453
	Female	0.3451 ± 0.0156	0.2967 ± 0.0179	0.3030 ± 0.0199	0.3355 ± 0.0096	0.3032 ± 0.0199	0.3539 ± 0.0160	0.2997 ± 0.0257	0.3382 ± 0.0090	0.3104 ± 0.0204	0.3125 ± 0.0224
Heart	Male	1.1572 ± 0.0898	1.6088 ± 0.1665	1.5266 ± 0.1471	1.1302 ± 0.2075	1.5934 ± 0.1625	1.1730 ± 0.0850	1.4677 ± 0.1040	1.1562 ± 0.0871	1.5236 ± 0.1646	1.5334 ± 0.2367
	Female	0.7574 ± 0.0447	0.9366 ± 0.0652	0.9298 ± 0.1196	0.7590 ± 0.0380	0.9729 ± 0.0742	0.7254 ± 0.0599	0.9469 ± 0.0530	0.7158 ± 0.0575	1.0124 ± 0.3391	0.9704 ± 0.0845
% to body weight	Male	0.3543 ± 0.0229	0.3317 ± 0.0228	0.3034 ± 0.0256	0.3499 ± 0.0445	0.3160 ± 0.0185	0.3551 ± 0.0177	0.3118 ± 0.0324	0.3560 ± 0.0208	0.3250 ± 0.0230	0.3010 ± 0.0324
	Female	0.3896 ± 0.0119	0.3484 ± 0.0209	0.3344 ± 0.0242	0.3893 ± 0.0152	0.3601 ± 0.0259	0.3705 ± 0.0346	0.3477 ± 0.0142	0.3683 ± 0.0374	0.3845 ± 0.1360	0.3465 ± 0.0266
Lung	Male	1.5656 ± 0.0698	1.9947 ± 0.1779	2.0066 ± 0.1561	1.4874 ± 0.1229	2.0049 ± 0.1510	1.5250 ± 0.1239	1.8534 ± 0.1209	1.5416 ± 0.1092	1.9613 ± 0.1305	1.8042 ± 0.1591
	Female	1.1890 ± 0.0432	1.4361 ± 0.1088	1.4584 ± 0.1603	1.2182 ± 0.1431	1.4594 ± 0.0892	1.2164 ± 0.1588	1.4234 ± 0.0721	1.1466 ± 0.0518	1.4478 ± 0.1077	1.4262 ± 0.1322
% to body weight	Male	0.4797 ± 0.0204	0.4114 ± 0.0208	0.3987 ± 0.0234	0.4637 ± 0.0366	0.3982 ± 0.0178	0.4610 ± 0.0128	0.3923 ± 0.0204	0.4744 ± 0.0180	0.4205 ± 0.0415	0.3571 ± 0.0440
	Female	0.6121 ± 0.0203	0.5337 ± 0.0229	0.5264 ± 0.0574	0.6234 ± 0.0522	0.5403 ± 0.0305	0.6207 ± 0.0833	0.5233 ± 0.0339	0.5891 ± 0.0283	0.5469 ± 0.0270	0.5094 ± 0.0439
Brain	Male	ND^b)	2.0641 ± 0.0562	2.0344 ± 0.0501	NDb)	2.0215 ± 0.0849	NDb)	1.9862 ± 0.0473	NDb)	2.0204 ± 0.0423	2.0450 ± 0.0802
	Female	ND^b)	1.8062 ± 0.0368	1.8284 ± 0.0730	NDb)	1.8646 ± 0.0732	NDb)	1.8016 ± 0.0678	NDb)	1.8069 ± 0.0602	1.8722 ± 0.0673
% to body weight	Male	ND^b)	0.4275 ± 0.0298	0.4048 ± 0.0137	NDb)	0.4026 ± 0.0255	NDb)	0.4220 ± 0.0351	NDb)	0.4329 ± 0.0277	0.4042 ± 0.0335
	Female	ND^b)	0.6726 ± 0.0258	0.6629 ± 0.0681	NDb)	0.6902 ± 0.0214	NDb)	0.6628 ± 0.0431	NDb)	0.6841 ± 0.0382	0.6695 ± 0.0368
Liver	Male	9.5912 ± 0.7911	11.8528 ± 1.1643	12.6104 ± 1.7035	9.3626 ± 0.9629	12.5935 ± 2.2636	10.1466 ± 0.5700	11.1793 ± 1.7555	9.5052 ± 0.5582	11.0740 ± 0.9159	13.0788 ± 2.8997
	Female	5.5920 ± 0.5099	6.4589 ± 0.7810	6.4812 ± 0.6049	5.5784 ± 0.5334	6.8322 ± 1.1330	5.5102 ± 0.3767	6.8610 ± 1.7458	5.5738 ± 0.5615	6.6866 ± 0.5558	6.6626 ± 0.9795
% to body weight	Male	2.9356 ± 0.1935	2.4422 ± 0.1178	2.5046 ± 0.3008	2.9083 ± 0.1159	2.4815 ± 0.2634	3.0727 ± 0.1101	2.3528 ± 0.2271	2.9256 ± 0.0668	2.3638 ± 0.1116	2.5611 ± 0.4535
	Female	2.8812 ± 0.2921	2.3981 ± 0.2116	2.3332 ± 0.0680	2.8595 ± 0.2334	2.5241 ± 0.3756	2.8115 ± 0.1862	2.4970 ± 0.4764	2.8554 ± 0.1547	2.5322 ± 0.2457	2.3763 ± 0.3002

^a) Represents body weights right before necropsy, after fasting.
^b) ND, not determined.
Values are mean ± SD (n = 5 (4 weeks or recovery) or 10 (26 weks)/sex/dose). P < 0.05 compare with normal group.

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