From: Safety and efficacy assessment of standardized herbal formula PM012
 |  |  | Dose (mg/kg) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Units | Sex | 0 | 500 | 1000 | 2000 | ||||||
 |  |  | 4 Weeks | 26 Weeks | Recovery | 4 Weeks | 26 Weeks | 4 Weeks | 26 Weeks | 4 Weeks | 26 Weeks | Recovery |
AST | U/L | Male | 113.90 ± 12.59 | 83.1 ± 11.4 | 90.0 ± 12.8 | 101.98 ± 14.09 | 78.5 ± 9.5 | 94.46 ± 12.02 | 85.9 ± 14.5 | 108.66 ± 24.97 | 84.1 ± 12.7 | 85.1 ± 21.5 |
 |  | Female | 97.10 ± 12.99 | 82.0 ± 10.0 | 83.9 ± 17.6 | 102.54 ± 16.78 | 81.9 ± 16.5 | 102.88 ± 7.01 | 81.9 ± 16.6 | 107.64 ± 21.81 | 80.3 ± 9.7 | 81.3 ± 13.2 |
ALT | U/L | Male | 35.06 ± 4.56 | 50.3 ± 10.5 | 52.1 ± 10.3 | 34.10 ± 4.28 | 44.3 ± 6.6 | 35.56 ± 4.18 | 48.8 ± 12.9 | 34.68 ± 4.66 | 41.9 ± 6.7 | 52.6 ± 8.4 |
 |  | Female | 27.14 ± 3.54 | 37.3 ± 7.8 | 36.4 ± 3.6 | 25.96 ± 2.36 | 35.8 ± 3.7 | 27.64 ± 1.90 | 33.4 ± 5.6 | 27.06 ± 1.64 | 36.1 ± 6.5 | 35.2 ± 3.9 |
ALP | U/L | Male | 133.96 ± 13.75 | 76.7 ± 11.9 | 84.6 ± 11.9 | 124.38 ± 9.96 | 77.0 ± 11.0 | 126.12 ± 9.52 | 79.5 ± 14.9 | 147.08 ± 19.36 | 73.1 ± 12.2 | 91.1 ± 9.1 |
 |  | Female | 87.20 ± 10.59 | 57.9 ± 12.2 | 54.1 ± 8.7 | 92.66 ± 15.55 | 62.3 ± 28.8 | 99.04 ± 18.32 | 50.6 ± 16.5 | 88.48 ± 3.48 | 54.7 ± 11.5 | 58.4 ± 13.4 |
CPK | U/L | Male | 408.4 ± 68.2 | 101.6 ± 25.6 | 199.8 ± 118.8 | 291.6 ± 96.3 | 98.9 ± 20.5 | 212.4 ± 92.1 | 114.7 ± 49.5 | 261.0 ± 152.6 | 122.8 ± 65.9 | 135.2 ± 64.9 |
 |  | Female | 265.8 ± 110.2 | 104.1 ± 31.7 | 143.8 ± 70.5 | 266.6 ± 142.2 | 87.2 ± 45.2 | 227.8 ± 78.6 | 81.9 ± 28.9 | 282.0 ± 148.6 | 85.0 ± 33.1 | 161.2 ± 68.4 |
BIL | mg/dL | Male | 0.21 ± 0.00 | 0.19 ± 0.02 | 0.19 ± 0.02 | 0.21 ± 0.00 | 0.21 ± 0.02 | 0.20 ± 0.01 | 0.19 ± 0.01 | 0.21 ± 0.01 | 0.20 ± 0.02 | 0.20 ± 0.01 |
 |  | Female | 0.21 ± 0.02 | 0.23 ± 0.03 | 0.26 ± 0.04 | 0.23 ± 0.02 | 0.23 ± 0.03 | 0.22 ± 0.02 | 0.23 ± 0.03 | 0.23 ± 0.02 | 0.24 ± 0.02 | 0.26 ± 0.05 |
GLU | mg/dL | Male | 102.18 ± 9.12 | 116.8 ± 9.1 | 120.5 ± 9.5 | 99.94 ± 5.77 | 121.3 ± 12.3 | 108.70 ± 9.87 | 113.7 ± 11.4 | 109.38 ± 8.60 | 113.3 ± 9.8 | 121.0 ± 8.4 |
 |  | Female | 106.66 ± 7.29 | 107.6 ± 10.7 | 130.5 ± 14.1 | 99.86 ± 3.54 | 111.6 ± 15.7 | 100.10 ± 5.58 | 110.0 ± 11.2 | 99.30 ± 9.04 | 106.2 ± 12.2 | 132.0 ± 7.4 |
CHO | mg/dL | Male | 90.4 ± 6.6 | 139.5 ± 27.3 | 165.0 ± 46.6 | 93.2 ± 12.8 | 152.9 ± 46.8 | 95.6 ± 9.4 | 123.2 ± 26.6 | 84.6 ± 9.9 | 116.0 ± 25.2 | 180.2 ± 73.0 |
 |  | Female | 96.8 ± 13.2 | 118.9 ± 13.0 | 119.0 ± 20.9 | 96.4 ± 20.6 | 119.1 ± 33.0 | 98.0 ± 11.6 | 138.5 ± 34.5 | 98.2 ± 17.2 | 126.4 ± 28.2 | 131.4 ± 24.5 |
TG | mg/dL | Male | 45.2 ± 8.2 | 49.6 ± 8.3 | 54.8 ± 18.9 | 46.8 ± 11.1 | 61.1 ± 20.2 | 44.4 ± 7.1 | 46.0 ± 10.4 | 46.4 ± 7.4 | 47.7 ± 7.3 | 63.4 ± 34.0 |
 |  | Female | 36.0 ± 8.1 | 43.5 ± 5.5 | 39.6 ± 5.3 | 36.4 ± 7.7 | 43.2 ± 6.6 | 36.2 ± 4.1 | 48.1 ± 6.5 | 39.4 ± 6.5 | 47.6 ± 9.0 | 44.0 ± 13.1 |
PRO | g/dL | Male | 6.04 ± 0.10 | 6.54 ± 0.14 | 6.38 ± 0.17 | 5.99 ± 0.23 | 6.48 ± 0.19 | 5.97 ± 0.10 | 6.42 ± 0.13 | 5.99 ± 0.24 | 6.50 ± 0.17 | 6.60 ± 0.21 |
 |  | Female | 5.63 ± 0.23 | 6.37 ± 0.16 | 6.84 ± 0.33 | 5.81 ± 0.38 | 6.65 ± 0.35 | 5.71 ± 0.23 | 6.60 ± 0.30 | 5.79 ± 0.13 | 6.76 ± 0.32 | 6.53 ± 0.20 |
ALB | g/dL | Male | 3.17 ± 0.05 | 2.99 ± 0.10 | 2.85 ± 0.14 | 3.14 ± 0.08 | 2.95 ± 0.11 | 3.15 ± 0.04 | 2.97 ± 0.07 | 3.18 ± 0.11 | 3.07 ± 0.12 | 2.83 ± 0.21 |
 |  | Female | 3.05 ± 0.11 | 3.16 ± 0.10 | 3.44 ± 0.26 | 3.16 ± 0.12 | 3.34 ± 0.12 | 3.08 ± 0.09 | 3.27 ± 0.19 | 3.14 ± 0.04 | 3.38 ± 0.20 | 3.25 ± 0.16 |
A/G | ratio | Male | 1.10 ± 0.00 | 0.84 ± 0.03 | 0.81 ± 0.09 | 1.10 ± 0.04 | 0.84 ± 0.08 | 1.12 ± 0.02 | 0.86 ± 0.05 | 1.14 ± 0.03 | 0.90 ± 0.06 | 0.76 ± 0.11 |
 |  | Female | 1.19 ± 0.05 | 0.98 ± 0.06 | 1.01 ± 0.10 | 1.20 ± 0.10 | 1.01 ± 0.05 | 1.17 ± 0.05 | 0.98 ± 0.05 | 1.18 ± 0.05 | 1.00 ± 0.05 | 0.99 ± 0.05 |
BUN | mg/dL | Male | 16.94 ± 1.66 | 16.0 ± 2.7 | 17.1 ± 3.5 | 15.26 ± 1.69 | 16.4 ± 2.1 | 14.52 ± 1.38 | 15.8 ± 2.3 | 15.86 ± 1.88 | 14.7 ± 2.4 | 16.9 ± 2.9 |
 |  | Female | 16.48 ± 1.47 | 17.5 ± 1.2 | 15.2 ± 2.0 | 16.60 ± 1.02 | 17.3 ± 1.1 | 16.24 ± 1.39 | 17.7 ± 1.9 | 17.14 ± 0.66 | 16.9 ± 1.9 | 14.6 ± 1.5 |
CRE | mg/dL | Male | 0.48 ± 0.07 | 0.57 ± 0.08 | 0.59 ± 0.07 | 0.49 ± 0.03 | 0.60 ± 0.04 | 0.48 ± 0.02 | 0.56 ± 0.03 | 0.50 ± 0.02 | 0.56 ± 0.02 | 0.62 ± 0.07 |
 |  | Female | 0.50 ± 0.03 | 0.63 ± 0.03 | 0.62 ± 0.04 | 0.52 ± 0.04 | 0.64 ± 0.05 | 0.53 ± 0.05 | 0.68 ± 0.07 | 0.53 ± 0.03 | 0.65 ± 0.05 | 0.61 ± 0.02 |
IP | mg/dL | Male | 8.57 ± 0.35 | 5.96 ± 0.38 | 5.92 ± 0.53 | 8.59 ± 0.14 | 6.16 ± 0.36 | 8.43 ± 0.42 | 6.08 ± 0.44 | 8.76 ± 0.39 | 6.37 ± 0.59 | 6.13 ± 0.14 |
 |  | Female | 8.08 ± 0.62 | 5.69 ± 0.86 | 4.43 ± 0.28 | 7.96 ± 0.58 | 5.17 ± 1.28 | 8.08 ± 0.50 | 5.53 ± 0.71 | 7.95 ± 0.38 | 5.76 ± 0.79 | 4.68 ± 0.24 |
Ca2+ | mg/dL | Male | 10.53 ± 0.14 | 10.48 ± 0.15 | 10.30 ± 0.28 | 10.47 ± 0.21 | 10.41 ± 0.20 | 10.40 ± 0.18 | 10.26 ± 0.09 | 10.34 ± 0.25 | 10.32 ± 0.13 | 10.39 ± 0.05 |
 |  | Female | 10.08 ± 0.25 | 10.08 ± 0.21 | 10.48 ± 0.34 | 10.05 ± 0.22 | 10.19 ± 0.31 | 10.03 ± 0.32 | 10.13 ± 0.22 | 9.81 ± 0.18 | 10.20 ± 0.22 | 10.21 ± 0.28 |
Na+ | mmol/L | Male | 148.2 ± 0.8 | 145.3 ± 0.9 | 143.9 ± 1.2 | 148.2 ± 0.8 | 144.7 ± 1.0 | 148.2 ± 1.3 | 144.5 ± 0.8 | 148.6 ± 0.9 | 145.3 ± 1.3 | 143.2 ± 0.7 |
 |  | Female | 146.2 ± 1.3 | 145.0 ± 0.9 | 141.9 ± 1.1 | 145.2 ± 2.4 | 144.1 ± 1.2 | 143.8 ± 0.8 | 143.5 ± 1.3 | 144.0 ± 1.0 | 143.5 ± 0.9 | 142.0 ± 1.1 |
K+ | mmol/L | Male | 4.82 ± 0.13 | 4.32 ± 0.18 | 4.57 ± 0.23 | 4.71 ± 0.22 | 4.19 ± 0.17 | 4.75 ± 0.12 | 4.36 ± 0.20 | 4.72 ± 0.14 | 4.31 ± 0.21 | 4.37 ± 0.25 |
 |  | Female | 4.71 ± 0.16 | 3.99 ± 0.15 | 3.99 ± 0.24 | 4.52 ± 0.16 | 4.36 ± 1.08 | 4.53 ± 0.11 | 4.20 ± 1.08 | 4.53 ± 0.43 | 4.04 ± 0.29 | 3.96 ± 0.32 |
Cl- | mmol/L | Male | 108.8 ± 0.4 | 105.7 ± 0.7 | 104.5 ± 1.2 | 108.4 ± 1.1 | 105.0 ± 1.8 | 108.2 ± 0.8 | 106.1 ± 0.9 | 108.6 ± 0.5 | 105.2 ± 1.1 | 103.5 ± 1.0 |
 |  | Female | 109.2 ± 0.8 | 106.5 ± 1.4 | 104.6 ± 0.9 | 109.2 ± 0.8 | 107.1 ± 0.7 | 108.0 ± 1.2 | 106.4 ± 0.9 | 108.2 ± 0.8 | 105.9 ± 1.1 | 104.7 ± 1.5 |