From: Safety and efficacy assessment of standardized herbal formula PM012
 |  |  | Hematological values | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Unit | Sex | 0 mg/kg | 500 mg/kg | 1000 mg/kg | 2000 mg/kg | ||||||
 |  |  | 4 Weeks | 26 Weeks | Recovery | 4 Weeks | 26 Weeks | 4 Weeks | 26 Weeks | 4 Weeks | 26 Weeks | Recovery |
WBC | 103/μL | Male | 11.12 ± 2.81 | 8.37 ± 1.35 | 7.63 ± 2.04 | 14.14 ± 2.29 | 9.47 ± 2.14 | 11.17 ± 3.22 | 8.35 ± 2.56 | 10.88 ± 3.18 | 8.99 ± 1.97 | 7.70 ± 1.07 |
 |  | Female | 6.78 ± 0.78 | 4.73 ± 0.92 | 5.82 ± 1.86 | 7.61 ± 0.75 | 4.20 ± 0.95 | 9.15 ± 3.92 | 4.83 ± 1.50 | 8.89 ± 2.60 | 4.93 ± 1.06 | 5.65 ± 1.43 |
RBC | 106/μL | Male | 8.03 ± 0.17 | 9.04 ± 0.28 | 8.72 ± 0.38 | 8.12 ± 0.24 | 9.12 ± 0.32 | 8.11 ± 0.20 | 8.86 ± 0.19 | 8.24 ± 0.06 | 8.89 ± 0.27 | 8.65 ± 0.26 |
 |  | Female | 7.99 ± 0.20 | 8.00 ± 0.25 | 7.68 ± 0.30 | 7.72 ± 0.43 | 8.09 ± 0.27 | 7.69 ± 0.29 | 8.12 ± 0.52 | 7.76 ± 0.18 | 7.96 ± 0.18 | 7.61 ± 0.22 |
HGB | g/dL | Male | 15.38 ± 0.53 | 15.5 ± 0.3 | 15.0 ± 0.8 | 15.40 ± 0.26 | 15.8 ± 0.5 | 15.42 ± 0.50 | 15.2 ± 0.4 | 15.44 ± 0.33 | 15.2 ± 0.3 | 14.9 ± 0.5 |
 |  | Female | 14.86 ± 0.41 | 14.5 ± 0.5 | 13.7 ± 0.5 | 14.54 ± 0.52 | 14.5 ± 0.4 | 14.50 ± 0.69 | 14.6 ± 0.7 | 14.88 ± 0.41 | 14.4 ± 0.5 | 14.1 ± 0.4 |
HCT | % | Male | 43.62 ± 1.40 | 46.2 ± 1.0 | 45.2 ± 2.4 | 43.62 ± 0.87 | 46.9 ± 1.3 | 43.76 ± 1.24 | 45.2 ± 1.4 | 43.82 ± 1.04 | 45.1 ± 0.9 | 44.3 ± 1.1 |
 |  | Female | 42.08 ± 0.88 | 42.5 ± 1.4 | 40.9 ± 1.4 | 41.50 ± 1.52 | 42.8 ± 1.4 | 40.94 ± 1.30 | 43.2 ± 1.8 | 41.74 ± 1.06 | 42.4 ± 1.2 | 41.5 ± 1.3 |
MCV | fL | Male | 54.28 ± 1.10 | 51.1 ± 1.5 | 51.9 ± 2.5 | 53.72 ± 1.45 | 51.5 ± 1.0 | 54.00 ± 1.22 | 51.1 ± 1.1 | 53.14 ± 1.48 | 50.8 ± 1.5 | 51.2 ± 0.9 |
 |  | Female | 52.68 ± 0.31 | 53.1 ± 0.7 | 53.2 ± 1.0 | 53.82 ± 1.25 | 52.9 ± 1.8 | 53.28 ± 0.75 | 53.3 ± 2.3 | 53.84 ± 1.00 | 53.3 ± 1.2 | 54.7 ± 0.5 |
MCH | pg | Male | 19.14 ± 0.43 | 17.2 ± 0.5 | 17.3 ± 0.8 | 19.00 ± 0.47 | 17.4 ± 0.4 | 19.06 ± 0.30 | 17.1 ± 0.3 | 18.74 ± 0.44 | 17.1 ± 0.4 | 17.2 ± 0.3 |
 |  | Female | 18.56 ± 0.19 | 18.1 ± 0.3 | 17.9 ± 0.2 | 18.88 ± 0.43 | 17.9 ± 0.5 | 18.88 ± 0.40 | 18.1 ± 0.7 | 19.18 ± 0.30 | 18.1 ± 0.5 | 18.4 ± 0.2 |
MCHC | g/dL | Male | 35.22 ± 0.18 | 33.6 ± 0.4 | 33.3 ± 0.3 | 35.32 ± 0.57 | 33.7 ± 0.4 | 35.28 ± 0.41 | 33.6 ± 0.4 | 35.28 ± 0.47 | 33.7 ± 0.3 | 33.7 ± 0.4 |
 |  | Female | 35.24 ± 0.48 | 34.1 ± 0.5 | 33.7 ± 0.2 | 35.06 ± 0.29 | 33.9 ± 0.6 | 35.38 ± 0.90 | 33.9 ± 0.5 | 35.58 ± 0.26 | 34.0 ± 0.4 | 33.8 ± 0.2 |
RDW | % | Male | 15.34 ± 0.47 | 12.3 ± 0.5 | 12.7 ± 0.6 | 15.30 ± 1.12 | 12.4 ± 0.5 | 15.52 ± 0.40 | 12.1 ± 0.4 | 15.24 ± 0.36 | 12.2 ± 0.3 | 12.5 ± 0.7 |
 |  | Female | 14.84 ± 0.38 | 11.1 ± 0.4 | 10.5 ± 0.4 | 13.96 ± 0.88 | 11.1 ± 0.5 | 14.58 ± 0.70 | 11.2 ± 0.5 | 14.18 ± 0.33 | 11.0 ± 0.3 | 11.0 ± 0.5 |
HDW | g/dL | Male | NDa) | 2.60 ± 0.14 | 2.73 ± 0.21 | NDa) | 2.68 ± 0.13 | NDa) | 2.52 ± 0.18 | NDa) | 2.58 ± 0.14 | 2.53 ± 0.27 |
 |  | Female | NDa) | 2.43 ± 0.20 | 2.20 ± 0.11 | NDa) | 2.29 ± 0.18 | NDa) | 2.39 ± 0.24 | NDa) | 2.36 ± 0.20 | 2.52 ± 0.23 |
PLT | 103/μL | Male | 945.2 ± 81.9 | 993.3 ± 82.7 | 10.54 ± 109.3 | 935.2 ± 37.8 | 1015.1 ± 107.4 | 869.6 ± 72.2 | 992.2 ± 66.3 | 930.4 ± 72.1 | 1024.1 ± 97.6 | 10.84.4 ± 77.0 |
 |  | Female | 997.0 ± 72.9 | 1016.5 ± 90.2 | 1013.2 ± 62.5 | 975.0 ± 43.6 | 1017.7 ± 69.6 | 997.8 ± 99.9 | 912.4 ± 264.7 | 985.6 ± 74.1 | 997.3 ± 91.4 | 1019.8 ± 79.7 |
MPV | fL | Male | 5.83 ± 0.49 | 5.92 ± 0.27 | 5.94 ± 0.29 | 5.67 ± 0.22 | 5.94 ± 0.20 | 5.91 ± 0.29 | 5.82 ± 0.17 | 5.81 ± 0.20 | 5.78 ± 0.15 | 5.98 ± 0.37 |
 |  | Female | 5.90 ± 0.33 | 6.02 ± 0.13 | 5.88 ± 0.13 | 5.90 ± 0.09 | 6.16 ± 0.25 | 5.67 ± 0.19 | 7.12 ± 2.44 | 5.73 ± 0.15 | 6.36 ± 0.84 | 5.90 ± 0.19 |
RET | % | Male | 2.2 ± 0.84 | 2.22 ± 0.22 | 2.31 ± 0.28 | 1.8 ± 0.84 | 2.20 ± 0.20 | 2.0 ± 1.41 | 2.10 ± 0.27 | 2.4 ± 1.14 | 2.15 ± 0.26 | 2.32 ± 0.30 |
 |  | Female | 3.4 ± 1.82 | 2.39 ± 0.33 | 1.81 ± 0.51 | 3.8 ± 1.30 | 2.47 ± 0.36 | 3.2 ± 1.48 | 2.30 ± 0.60 | 2.2 ± 1.64 | 2.26 ± 0.28 | 2.36 ± 0.27 |
NEU | % | Male | 12.75 ± 3.77 | 26.6 ± 10.7 | 16.2 ± 4.5 | 9.81 ± 2.15 | 29.8 ± 8.9 | 14.30 ± 4.91 | 25.2 ± 11.0 | 13.06 ± 6.29 | 23.5 ± 7.1 | 17.5 ± 6.0 |
 |  | Female | 10.25 ± 1.99 | 16.8 ± 4.5 | 31.3 ± 13.9 | 9.06 ± 2.03 | 16.6 ± 2.3 | 9.87 ± 4.91 | 17.1 ± 5.3 | 9.46 ± 2.87 | 16.3 ± 3.6 | 15.4 ± 3.7 |
LYM | % | Male | 79.76 ± 5.96 | 68.2 ± 10.7 | 77.2 ± 5.0 | 84.80 ± 2.56 | 64.6 ± 8.6 | 77.52 ± 5.76 | 69.0 ± 10.5 | 79.90 ± 7.43 | 70.6 ± 6.5 | 74.7 ± 7.8 |
 |  | Female | 82.46 ± 3.14 | 78.0 ± 4.5 | 61.9 ± 12.5 | 85.10 ± 2.67 | 77.6 ± 2.3 | 83.96 ± 5.54 | 76.4 ± 6.5 | 83.84 ± 2.46 | 77.8 ± 4.0 | 77.8 ± 4.1 |
MONO | % | Male | 4.40 ± 1.85 | 3.05 ± 0.36 | 4.12 ± 1.52 | 2.77 ± 1.01 | 3.57 ± 1.09 | 4.41 ± 1.39 | 3.52 ± 0.96 | 3.66 ± 0.97 | 3.74 ± 0.90 | 5.36 ± 1.81 |
 |  | Female | 3.75 ± 1.08 | 2.77 ± 0.79 | 4.24 ± 1.05 | 2.84 ± 0.80 | 3.01 ± 0.65 | 2.90 ± 0.70 | 3.64 ± 0.98 | 3.33 ± 0.50 | 3.68 ± 0.94 | 3.92 ± 0.33 |
EOS | % | Male | 0.64 ± 0.27 | 1.47 ± 0.36 | 1.52 ± 0.59 | 0.53 ± 0.32 | 1.29 ± 0.49 | 0.64 ± 0.10 | 1.62 ± 0.62 | 0.83 ± 0.39 | 1.40 ± 0.75 | 1.08 ± 0.42 |
 |  | Female | 0.95 ± 0.64 | 1.67 ± 0.47 | 1.74 ± 0.58 | 0.83 ± 0.33 | 2.04 ± 0.87 | 0.97 ± 0.52 | 1.79 ± 0.58 | 0.88 ± 0.29 | 1.36 ± 0.37 | 2.04 ± 0.42 |
BASO | % | Male | 2.43 ± 0.75 | 0.12 ± 0.06 | 0.16 ± 0.05 | 2.10 ± 0.60 | 0.15 ± 0.05 | 3.11 ± 0.44 | 0.17 ± 0.08 | 2.56 ± 0.47 | 0.17 ± 0.07 | 0.22 ± 0.04 |
 |  | Female | 2.58 ± 0.61 | 0.12 ± 0.06 | 0.10 ± 0.00 | 2.18 ± 0.45 | 0.18 ± 0.15 | 2.31 ± 0.45 | 0.16 ± 0.08 | 2.50 ± 0.56 | 0.12 ± 0.04 | 0.12 ± 0.04 |
LUC | % | Male | NDa) | 0.57 ± 0.22 | 0.78 ± 0.26 | NDa) | 0.63 ± 0.33 | NDa) | 0.58 ± 0.15 | NDa) | 0.61 ± 0.23 | 1.14 ± 0.92 |
 |  | Female | NDa) | 0.62 ± 0.21 | 0.74 ± 0.30 | NDa) | 0.65 ± 0.35 | NDa) | 0.86 ± 0.31 | NDa) | 0.72 ± 0.35 | 0.74 ± 0.28 |