Skip to main content

Table 3 Hematological values in rats orally treated with PM012

From: Safety and efficacy assessment of standardized herbal formula PM012

   

Hematological values

Parameter

Unit

Sex

0 mg/kg

500 mg/kg

1000 mg/kg

2000 mg/kg

   

4 Weeks

26 Weeks

Recovery

4 Weeks

26 Weeks

4 Weeks

26 Weeks

4 Weeks

26 Weeks

Recovery

WBC

103/μL

Male

11.12 ± 2.81

8.37 ± 1.35

7.63 ± 2.04

14.14 ± 2.29

9.47 ± 2.14

11.17 ± 3.22

8.35 ± 2.56

10.88 ± 3.18

8.99 ± 1.97

7.70 ± 1.07

  

Female

6.78 ± 0.78

4.73 ± 0.92

5.82 ± 1.86

7.61 ± 0.75

4.20 ± 0.95

9.15 ± 3.92

4.83 ± 1.50

8.89 ± 2.60

4.93 ± 1.06

5.65 ± 1.43

RBC

106/μL

Male

8.03 ± 0.17

9.04 ± 0.28

8.72 ± 0.38

8.12 ± 0.24

9.12 ± 0.32

8.11 ± 0.20

8.86 ± 0.19

8.24 ± 0.06

8.89 ± 0.27

8.65 ± 0.26

  

Female

7.99 ± 0.20

8.00 ± 0.25

7.68 ± 0.30

7.72 ± 0.43

8.09 ± 0.27

7.69 ± 0.29

8.12 ± 0.52

7.76 ± 0.18

7.96 ± 0.18

7.61 ± 0.22

HGB

g/dL

Male

15.38 ± 0.53

15.5 ± 0.3

15.0 ± 0.8

15.40 ± 0.26

15.8 ± 0.5

15.42 ± 0.50

15.2 ± 0.4

15.44 ± 0.33

15.2 ± 0.3

14.9 ± 0.5

  

Female

14.86 ± 0.41

14.5 ± 0.5

13.7 ± 0.5

14.54 ± 0.52

14.5 ± 0.4

14.50 ± 0.69

14.6 ± 0.7

14.88 ± 0.41

14.4 ± 0.5

14.1 ± 0.4

HCT

%

Male

43.62 ± 1.40

46.2 ± 1.0

45.2 ± 2.4

43.62 ± 0.87

46.9 ± 1.3

43.76 ± 1.24

45.2 ± 1.4

43.82 ± 1.04

45.1 ± 0.9

44.3 ± 1.1

  

Female

42.08 ± 0.88

42.5 ± 1.4

40.9 ± 1.4

41.50 ± 1.52

42.8 ± 1.4

40.94 ± 1.30

43.2 ± 1.8

41.74 ± 1.06

42.4 ± 1.2

41.5 ± 1.3

MCV

fL

Male

54.28 ± 1.10

51.1 ± 1.5

51.9 ± 2.5

53.72 ± 1.45

51.5 ± 1.0

54.00 ± 1.22

51.1 ± 1.1

53.14 ± 1.48

50.8 ± 1.5

51.2 ± 0.9

  

Female

52.68 ± 0.31

53.1 ± 0.7

53.2 ± 1.0

53.82 ± 1.25

52.9 ± 1.8

53.28 ± 0.75

53.3 ± 2.3

53.84 ± 1.00

53.3 ± 1.2

54.7 ± 0.5

MCH

pg

Male

19.14 ± 0.43

17.2 ± 0.5

17.3 ± 0.8

19.00 ± 0.47

17.4 ± 0.4

19.06 ± 0.30

17.1 ± 0.3

18.74 ± 0.44

17.1 ± 0.4

17.2 ± 0.3

  

Female

18.56 ± 0.19

18.1 ± 0.3

17.9 ± 0.2

18.88 ± 0.43

17.9 ± 0.5

18.88 ± 0.40

18.1 ± 0.7

19.18 ± 0.30

18.1 ± 0.5

18.4 ± 0.2

MCHC

g/dL

Male

35.22 ± 0.18

33.6 ± 0.4

33.3 ± 0.3

35.32 ± 0.57

33.7 ± 0.4

35.28 ± 0.41

33.6 ± 0.4

35.28 ± 0.47

33.7 ± 0.3

33.7 ± 0.4

  

Female

35.24 ± 0.48

34.1 ± 0.5

33.7 ± 0.2

35.06 ± 0.29

33.9 ± 0.6

35.38 ± 0.90

33.9 ± 0.5

35.58 ± 0.26

34.0 ± 0.4

33.8 ± 0.2

RDW

%

Male

15.34 ± 0.47

12.3 ± 0.5

12.7 ± 0.6

15.30 ± 1.12

12.4 ± 0.5

15.52 ± 0.40

12.1 ± 0.4

15.24 ± 0.36

12.2 ± 0.3

12.5 ± 0.7

  

Female

14.84 ± 0.38

11.1 ± 0.4

10.5 ± 0.4

13.96 ± 0.88

11.1 ± 0.5

14.58 ± 0.70

11.2 ± 0.5

14.18 ± 0.33

11.0 ± 0.3

11.0 ± 0.5

HDW

g/dL

Male

NDa)

2.60 ± 0.14

2.73 ± 0.21

NDa)

2.68 ± 0.13

NDa)

2.52 ± 0.18

NDa)

2.58 ± 0.14

2.53 ± 0.27

  

Female

NDa)

2.43 ± 0.20

2.20 ± 0.11

NDa)

2.29 ± 0.18

NDa)

2.39 ± 0.24

NDa)

2.36 ± 0.20

2.52 ± 0.23

PLT

103/μL

Male

945.2 ± 81.9

993.3 ± 82.7

10.54 ± 109.3

935.2 ± 37.8

1015.1 ± 107.4

869.6 ± 72.2

992.2 ± 66.3

930.4 ± 72.1

1024.1 ± 97.6

10.84.4 ± 77.0

  

Female

997.0 ± 72.9

1016.5 ± 90.2

1013.2 ± 62.5

975.0 ± 43.6

1017.7 ± 69.6

997.8 ± 99.9

912.4 ± 264.7

985.6 ± 74.1

997.3 ± 91.4

1019.8 ± 79.7

MPV

fL

Male

5.83 ± 0.49

5.92 ± 0.27

5.94 ± 0.29

5.67 ± 0.22

5.94 ± 0.20

5.91 ± 0.29

5.82 ± 0.17

5.81 ± 0.20

5.78 ± 0.15

5.98 ± 0.37

  

Female

5.90 ± 0.33

6.02 ± 0.13

5.88 ± 0.13

5.90 ± 0.09

6.16 ± 0.25

5.67 ± 0.19

7.12 ± 2.44

5.73 ± 0.15

6.36 ± 0.84

5.90 ± 0.19

RET

%

Male

2.2 ± 0.84

2.22 ± 0.22

2.31 ± 0.28

1.8 ± 0.84

2.20 ± 0.20

2.0 ± 1.41

2.10 ± 0.27

2.4 ± 1.14

2.15 ± 0.26

2.32 ± 0.30

  

Female

3.4 ± 1.82

2.39 ± 0.33

1.81 ± 0.51

3.8 ± 1.30

2.47 ± 0.36

3.2 ± 1.48

2.30 ± 0.60

2.2 ± 1.64

2.26 ± 0.28

2.36 ± 0.27

NEU

%

Male

12.75 ± 3.77

26.6 ± 10.7

16.2 ± 4.5

9.81 ± 2.15

29.8 ± 8.9

14.30 ± 4.91

25.2 ± 11.0

13.06 ± 6.29

23.5 ± 7.1

17.5 ± 6.0

  

Female

10.25 ± 1.99

16.8 ± 4.5

31.3 ± 13.9

9.06 ± 2.03

16.6 ± 2.3

9.87 ± 4.91

17.1 ± 5.3

9.46 ± 2.87

16.3 ± 3.6

15.4 ± 3.7

LYM

%

Male

79.76 ± 5.96

68.2 ± 10.7

77.2 ± 5.0

84.80 ± 2.56

64.6 ± 8.6

77.52 ± 5.76

69.0 ± 10.5

79.90 ± 7.43

70.6 ± 6.5

74.7 ± 7.8

  

Female

82.46 ± 3.14

78.0 ± 4.5

61.9 ± 12.5

85.10 ± 2.67

77.6 ± 2.3

83.96 ± 5.54

76.4 ± 6.5

83.84 ± 2.46

77.8 ± 4.0

77.8 ± 4.1

MONO

%

Male

4.40 ± 1.85

3.05 ± 0.36

4.12 ± 1.52

2.77 ± 1.01

3.57 ± 1.09

4.41 ± 1.39

3.52 ± 0.96

3.66 ± 0.97

3.74 ± 0.90

5.36 ± 1.81

  

Female

3.75 ± 1.08

2.77 ± 0.79

4.24 ± 1.05

2.84 ± 0.80

3.01 ± 0.65

2.90 ± 0.70

3.64 ± 0.98

3.33 ± 0.50

3.68 ± 0.94

3.92 ± 0.33

EOS

%

Male

0.64 ± 0.27

1.47 ± 0.36

1.52 ± 0.59

0.53 ± 0.32

1.29 ± 0.49

0.64 ± 0.10

1.62 ± 0.62

0.83 ± 0.39

1.40 ± 0.75

1.08 ± 0.42

  

Female

0.95 ± 0.64

1.67 ± 0.47

1.74 ± 0.58

0.83 ± 0.33

2.04 ± 0.87

0.97 ± 0.52

1.79 ± 0.58

0.88 ± 0.29

1.36 ± 0.37

2.04 ± 0.42

BASO

%

Male

2.43 ± 0.75

0.12 ± 0.06

0.16 ± 0.05

2.10 ± 0.60

0.15 ± 0.05

3.11 ± 0.44

0.17 ± 0.08

2.56 ± 0.47

0.17 ± 0.07

0.22 ± 0.04

  

Female

2.58 ± 0.61

0.12 ± 0.06

0.10 ± 0.00

2.18 ± 0.45

0.18 ± 0.15

2.31 ± 0.45

0.16 ± 0.08

2.50 ± 0.56

0.12 ± 0.04

0.12 ± 0.04

LUC

%

Male

NDa)

0.57 ± 0.22

0.78 ± 0.26

NDa)

0.63 ± 0.33

NDa)

0.58 ± 0.15

NDa)

0.61 ± 0.23

1.14 ± 0.92

  

Female

NDa)

0.62 ± 0.21

0.74 ± 0.30

NDa)

0.65 ± 0.35

NDa)

0.86 ± 0.31

NDa)

0.72 ± 0.35

0.74 ± 0.28

  1. * WBC: white blood cell, RBC: red blood cell, HGB: hemoglobin concentration, HCT: hematocrit, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, RDW: Red cell distribution width, PLT: Platelet, MPV: Mean platelet volume, RET: Reticulocyte, NEU: Neutrophil, LYM: Lymphocyte, MONO: Monocyte, EOS: Eosinophil, BASO: Basophil. Values are mean ± SD (n = 5 (4 weeks) or 10 (26 weks)/sex/dose). P < 0.05 compare with normal group. b) ND, not determined.