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Table 3 Impact of drug intervention on the animal daily behavior in bile duct ligation-induced liver fibrotic rats (n = 7, x ¯ ± s )

From: A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats

Index Body weight (g) Water drinking (mL per rat) feeding (g per rat)
group dose mg/kg n D0 D14 D21 D28 D0 D14 D21 D28 D0 D14 D21 D28
Normal 7 207 ± 12.0 328 ± 9.6 382 ± 12.1 389 ± 17.7 37.5 ± 0.0 56.9 ± 8.0 53.1 ± 2.7 51.3 ± 8.8 32.3 ± 11.1 31.1 ± 18.4 32.8 ± 2.4 33.8 ± 0.7
Sham 7 214 ± 5.4 321 ± 18.9 384 ± 26.2 389 ± 28.3 54.4 ± 6.2 60.0 ± 14.1 60.6 ± 4.4 62.5 ± 7.1 38.4 ± 0.7 34.0 ± 3.0 32.0 ± 0.0 27.1 ± 5.1
Model 7 213 ± 7.8 290 ± 16.2 332 ± 18.2 338 ± 26.0 41.3 ± 1.8 74.7 ± 1.9 54.0 ± 5.7 48.3 ± 11.8 8.7 ± 3.9 27.1 ± 1.6 27.7 ± 3.0 26.2 ± 1.9
Silymarin 150 7 210 ± 6.2 260 ± 24.4 289 ± 15.8 291 ± 15.2 57.4 ± 1.9 85.0 ± 49.5 72.3 ± 0.9* 59.3 ± 3.8* 8.3 ± 2.7 26.9 ± 4.6 22.9 ± 0.4 21.0 ± 0.6
Berberine 120 7 210 ± 6.2 294 ± 29.9 342 ± 31.0 340 ± 32.0 36.1 ± 0.2 76.3 ± 23.0 78.8 ± 3.1** 62.5 ± 7.1** 9.4 ± 1.0 25.7 ± 3.9 28.1 ± 1.9 28.9 ± 3.0
CRAE 600 7 208 ± 6.0 275 ± 25.2 320 ± 3.5 324 ± 2.4 55.0 ± 14.1 70.8 ± 8.2 75.8 ± 5.9** 61.3 ± 15.9* 7.8 ± 1.7 21.6 ± 11.0 28.6 ± 3.9 28.7 ± 1.3
Bear bile 200 7 207 ± 7.5 293 ± 38.5 331 ± 60.5 345 ± 64.7 34.4 ± 0.9 81.3 ± 1.8 75.6 ± 2.7** 72.5 ± 10.6** 8.2 ± 2.2 24.6 ± 1.2 28.2 ± 1.9 29.4 ± 0.8
TUDCA 20 7 212 ± 5.5 279 ± 30.1 311 ± 58.9 307 ± 72.5 30.1 ± 5.5 76.7 ± 28.3 78.3 ± 11.8** 63.3 ± 18.9* 6.9 ± 2.6 24.2 ± 1.3 26.3 ± 2.1 24.8 ± 4.6
  1. p < 0.05 when compared with normal group; p < 0.01 when compared with normal group; *p < 0.05 when compared with model group; **p < 0.01 when compared with model group.