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Table 2 Impact of drug intervention on the animal daily behavior in CCl 4 -induced liver fibrotic rats (n = 7, x ¯ ± s )

From: A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats

Index

Body weight (g)

Water drinking (mL per rat)

feeding (g per rat)

Group

dose mg/kg

n

D0

D14

D35

D49

D0

D14

D35

D49

D0

D14

D35

D49

Normal

—

7

195 ± 6.1

303 ± 10.0

368 ± 41.2

416 ± 25.4

41.0 ± 1.4

60.0 ± 21.2

43.1 ± 11.5

61.4 ± 0.9

21.8 ± 2.0

37.6 ± 0.6

25.7 ± 0.2

23.8 ± 0.2

Model

—

7

198 ± 9.5

267 ± 40.3△△

288 ± 15.6△△

302 ± 17.2△△

36.7 ± 2.4

41.7 ± 9.4

35.0 ± 4.7

26.8 ± 2.5△

18.1 ± 1.2

29.5 ± 2.4

20.2 ± 4.5

17.6 ± 7.4

Silymarin

150

7

192 ± 8.3

260 ± 40.4

293 ± 46.0

306 ± 55.1

47.0 ± 9.9

33.8 ± 5.3

27.5 ± 0.0

22.9 ± 7.7

21.7 ± 2.3

22.3 ± 9.8

17.3 ± 4.1

19.5 ± 5.0

Berberine

120

7

195 ± 5.3

277 ± 23.3

292 ± 33.4

309 ± 28.9

41.0 ± 1.4

37.5 ± 0.0

40.4 ± 4.1

34.3 ± 7.8

19.1 ± 2.9

25.3 ± 0.2

20.1 ± 1.1

19.5 ± 0.5

CRAE

600

7

195 ± 7.5

271 ± 24.6

300 ± 30.8

318 ± 35.7

34.0 ± 8.5

35.6 ± 2.7

34.4 ± 0.9

28.3 ± 4.7

16.1 ± 0.0

25.3 ± 3.3

17.8 ± 4.1

19.3 ± 1.2

Bear bile

200

7

201 ± 1.3

285 ± 21.4

321 ± 19.1

358 ± 40.7

33.0 ± 1.4

31.9 ± 9.7

36.3 ± 7.1

31.2 ± 3.5

19.0 ± 0.6

24.8 ± 3.7

22.5 ± 2.2

19.9 ± 0.3

TUDCA

20

7

194 ± 8.8

278 ± 18.1

296 ± 22.3

320 ± 28.2

41.5 ± 3.5

31.3 ± 8.8

37.1 ± 7.7

26.3 ± 8.8

16.2 ± 6.8

23.7 ± 0.3

15.3 ± 2.1

18.9 ± 2.8

  1. △p < 0.05 when compared with normal group; △△p < 0.01 when compared with normal group.