Index | Body weight (g) | Water drinking (mL per rat) | feeding (g per rat) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Group | dose mg/kg | n | D0 | D14 | D35 | D49 | D0 | D14 | D35 | D49 | D0 | D14 | D35 | D49 |
Normal | — | 7 | 195 ± 6.1 | 303 ± 10.0 | 368 ± 41.2 | 416 ± 25.4 | 41.0 ± 1.4 | 60.0 ± 21.2 | 43.1 ± 11.5 | 61.4 ± 0.9 | 21.8 ± 2.0 | 37.6 ± 0.6 | 25.7 ± 0.2 | 23.8 ± 0.2 |
Model | — | 7 | 198 ± 9.5 | 267 ± 40.3△△ | 288 ± 15.6△△ | 302 ± 17.2△△ | 36.7 ± 2.4 | 41.7 ± 9.4 | 35.0 ± 4.7 | 26.8 ± 2.5△ | 18.1 ± 1.2 | 29.5 ± 2.4 | 20.2 ± 4.5 | 17.6 ± 7.4 |
Silymarin | 150 | 7 | 192 ± 8.3 | 260 ± 40.4 | 293 ± 46.0 | 306 ± 55.1 | 47.0 ± 9.9 | 33.8 ± 5.3 | 27.5 ± 0.0 | 22.9 ± 7.7 | 21.7 ± 2.3 | 22.3 ± 9.8 | 17.3 ± 4.1 | 19.5 ± 5.0 |
Berberine | 120 | 7 | 195 ± 5.3 | 277 ± 23.3 | 292 ± 33.4 | 309 ± 28.9 | 41.0 ± 1.4 | 37.5 ± 0.0 | 40.4 ± 4.1 | 34.3 ± 7.8 | 19.1 ± 2.9 | 25.3 ± 0.2 | 20.1 ± 1.1 | 19.5 ± 0.5 |
CRAE | 600 | 7 | 195 ± 7.5 | 271 ± 24.6 | 300 ± 30.8 | 318 ± 35.7 | 34.0 ± 8.5 | 35.6 ± 2.7 | 34.4 ± 0.9 | 28.3 ± 4.7 | 16.1 ± 0.0 | 25.3 ± 3.3 | 17.8 ± 4.1 | 19.3 ± 1.2 |
Bear bile | 200 | 7 | 201 ± 1.3 | 285 ± 21.4 | 321 ± 19.1 | 358 ± 40.7 | 33.0 ± 1.4 | 31.9 ± 9.7 | 36.3 ± 7.1 | 31.2 ± 3.5 | 19.0 ± 0.6 | 24.8 ± 3.7 | 22.5 ± 2.2 | 19.9 ± 0.3 |
TUDCA | 20 | 7 | 194 ± 8.8 | 278 ± 18.1 | 296 ± 22.3 | 320 ± 28.2 | 41.5 ± 3.5 | 31.3 ± 8.8 | 37.1 ± 7.7 | 26.3 ± 8.8 | 16.2 ± 6.8 | 23.7 ± 0.3 | 15.3 ± 2.1 | 18.9 ± 2.8 |