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Table 4 Effect of test materials and propanolol (reference control) on mean arterial blood pressure of rats

From: Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models

Group Dose (mg/kg bw.) Mean arterial pressure (mmHg)
   Before induction of hypertension After induction of hypertension After treatment of hypertension
Normal - 107 ± 3.1 110 ± 3.4 109 ± 2.7
Untreated control - 108 ± 3.4 143 ± 2.7 151 ± 3.0
Propanolol-treated 10 110 ± 3.2 145 ± 3.1 116 ± 2.5*
CUR 1000 106 ± 0.4 145 ± 0.3 138 ± 0.5
  3000 104 ± 0.3 146 ± 0.4 137 ± 0.4
  5000 107 ± 0.3 148 ± 0.3 135 ± 0.4
ZO 1000 105 ± 0.3 144 ± 0.4 135 ± 0.5
  3000 107 ± 0.4 147 ± 0.5 137 ± 0.3
  5000 106 ± 0.3 148 ± 0.4 119 ± 0.3*
AL 1000 105 ± 0.3 148 ± 0.5 118 ± 0.4*
  3000 107 ± 0.4 144 ± 0.4 120 ± 0.4*
  5000 106 ± 0.3 148 ± 0.4 122 ± 0.3*
PC 100 103 ± 0.3 147 ± 0.3 134 ± 0.5
  500 105 ± 0.4 149 ± 0.4 124 ± 0.4*
  1000 105 ± 0.4 147 ± 0.4 125 ± 0.4*
PPF 1000 104 ± 0.3 145 ± 0.4 134 ± 0.3
  2000 108 ± 0.4 146 ± 0.5 134 ± 0.4
  4000 104 ± 0.4 143 ± 0.5 134 ± 0.5
  1. Data are presented as mean ± SEM values
  2. *Statistically significant difference with baseline by paired t-test:
  3. sBP and dBP of ZO-treated group at high dose level (p < 0.001)
  4. sBP and dBP of AL-treated group at all dose levels (p < 0.001)
  5. sBP and dBP of PC-treated group at medium and high dose levels (p < 0.001)
  6. sBP and dBP of propanolol-treated group (p < 0.001)