Table 4 Main specific gene ontology categories observed in clusters derived from union PPPI network

Cluster 1

Translation

6416

2.07 x 10^-45

2.93 x 10^-43

45

499

Ribosome assembly

42255

1.82 x 10^-9

2.58 x 10^-8

9

65

Negative regulation of mRNA processing

50686

8.25 x 10^-3

3.90 x 10^-2

1

1

Cluster 2

Organic acid transport

15849

2.0594 x 10^-4

1.4107 x 10^-2

3

65

Choline transport

15871

1.8904 x 10^-3

3.2372 x 10^-2

1

1

Betaine transport

15838

1.8904 x 10^-3

3.2372 x 10^-2

1

1

Ethanolamine transport

34229

1.8904 x 10^-3

3.2372 x 10^-2

1

1

Amino acid transport

6865

3.4951 x 10^-3

4.7047 x 10^-2

2

48

Cluster 3

Mitochondrial transport

6839

1.74 x 10^-10

3.88 x 10^-9

5

67

Mitochondrion organization and biogenesis

7005

2.6080 x 10^-8

2.9122 x 10^-7

5

179

Protein transport

15031

3.7859 x 10^-6

2.1138 x 10^-5

5

481

Membrane organization and biogenesis

16044

3.5801 x 10^-4

1.0903 x 10^-3

3

196

Cluster 4

Transcription from RNA polymerase II promoter

6366

3.4996 x 10^-11

3.4296 x 10^-9

9

162

Histone modification

16570

1.1400 x 10^-9

2.2345 x 10^-8

7

92

Establishment and/or maintenance of chromatin architecture

6325

2.4536 x 10^-9

4.3719 x 10^-8

9

260

Transcription, DNA-dependent

6351

5.8940 x 10^-9

8.7746 x 10^-8

9

287

G1 phase of mitotic cell cycle

80

1.0490 x 10^-8

1.2850 x 10^-7

5

32

Regulation of RNA metabolic process

51252

1.5270 x 10^-8

1.5753 x 10^-7

11

614

Chromosome organization and biogenesis

7001

1.0393 x 10^-7

8.8567 x 10^-7

9

398

Response to drug

17035

3.3259 x 10^-3

1.1436 x 10^-2

3

121

Cell cycle

7049

1.1244 x 10^-2

3.5546 x 10^-2

5

566

Cluster 5

DNA catabolic process

6308

7.6846 x 10^-5

6.1477 x 10^-4

2

30

Meiotic recombination

7145

2.8107 x 10^-4

1.6864 x 10^-3

2

57

Double-strand break repair

6302

3.0125 x 10^-4

1.7012 x 10^-3

2

59

M phase of meiotic cell cycle

51327

2.6749 x 10^-3

7.7814 x 10^-3

2

176

Telomere maintenance via recombination

722

9.7652 x 10^-3

2.5337 x 10^-2

1

19

Cluster 6

ER to Golgi vesicle-mediated transport

6888

6.1201 x 10^-4

2.5773 x 10^-2

2

84

Cluster 7

Negative regulation of RNA metabolic process

51253

2.4984 x 10^-6

8.0002 x 10^-5

4

157

Negative regulation of transcription

16481

3.1251 x 10^-6

8.0002 x 10^-5

4

166

Heterochromatin formation

31507

3.7388 x 10^-5

2.9910 x 10^-4

3

92

Chromatin silencing

6342

3.7388 x 10^-5

2.9910 x 10^-4

3

92

Gene silencing

16458

5.4046 x 10^-5

3.8433 x 10^-4

3

104

Chromatin modification

16568

5.8205 x 10^-4

2.8655 x 10^-3

3

231

Regulation of cell cycle

74

7.1144 x 10^-3

1.5701 x 10^-2

2

160

Cluster 8

RNA biosynthetic process

32774

2.4585 x 10^-3

1.8302 x 10^-2

2

289

Transcription

6350

1.0545 x 10^-2

4.8996 x 10^-2

2

598

Cluster 9

Intracellular pH reduction

51452

4.8791 x 10^-5

6.6815 x 10^-4

2

24

Vacuolar acidification

7035

4.8791 x 10^-5

6.6815 x 10^-4

2

24

Regulation of intracellular pH

51453

5.3028 x 10^-5

6.6815 x 10^-4

2

25

Proton transport

15992

1.1756 x 10^-4

9.1538 x 10^-4

2

37

Cellular homeostasis

19725

2.1588 x 10^-3

6.8004 x 10^-3

2

158

Ion transport

6811

2.3248 x 10^-3

6.9745 x 10^-3

2

164

ATP metabolic process

46034

1.2324 x 10^-2

2.9858 x 10^-2

1

24

Cluster 10

Histone methylation

16571

1.2655 x 10^-9

1.0504 x 10^-7

5

17

Regulation of transcription

45449

5.8795 x 10^-8

2.0914 x 10^-6

12

631

Post-translational protein modification

43687

3.6875 x 10^-7

3.9921 x 10^-6

10

454

Chromosome organization and biogenesis

7001

1.7266 x 10^-5

9.3463 x 10^-5

8

398

Regulation of conjugation with cellular fusion

31137

4.4395 x 10^-3

1.3481 x 10^-2

2

31

Ethanol biosynthetic process during fermentation

43458

6.5202 x 10^-3

1.7647 x 10^-2

1

2

Response to stress

6950

1.2590 x 10^-2

2.9574 x 10^-2

6

632

Glycolytic fermentation

19660

2.2645 x 10^-2

4.6218 x 10^-2

1

7

Cluster 11

Chromosome organization and biogenesis

7001

1.1865 x 10^-3

2.9377 x 10^-2

5

398

DNA repair

6281

1.2413 x 10^-3

2.9377 x 10^-2

4

228

Mitotic cell cycle

278

3.2147 x 10^-3

4.5671 x 10^-2

4

295

Histone acetylation

16573

3.4260 x 10-3

4.5671 x 10^-2

2

40